hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07554.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BAK1 | Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) | 5 | UniProt NCBI |
| BBC3 | Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis) | 5 | UniProt NCBI |
| BAX | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | 5 | UniProt NCBI |
| BCL2L15 | Bcl-2-like protein 15 (Bcl2-L-15) (Bcl-2 family kin) (Bfk) | 4 | UniProt NCBI |
| BCL2L11 | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 3.02959148518e-09 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Apoptosis - multiple species |
| GO:1903896 | 9.20740386965e-09 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of IRE1-mediated unfolded protein response |
| GO:1900103 | 6.50952358374e-08 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of endoplasmic reticulum unfolded protein response |
| REAC:R-HSA-109606 | 1.15337100464e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Intrinsic Pathway for Apoptosis |
| WP:WP4216 | 1.26247088102e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Chromosomal and microsatellite instability in colorectal cancer |
| GO:1903894 | 1.31622611039e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of IRE1-mediated unfolded protein response |
| WP:WP254 | 1.79216443484e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Apoptosis |
| KEGG:05210 | 1.81460780011e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Colorectal cancer |
| WP:WP1772 | 2.34804778155e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Apoptosis modulation and signaling |
| GO:0036498 | 4.02274655956e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | IRE1-mediated unfolded protein response |
| WP:WP710 | 6.71243202026e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | DNA damage response only ATM dependent |
| GO:0090200 | 9.61435992643e-07 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of release of cytochrome c from mitochondria |
| KEGG:04210 | 1.04259280628e-06 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Apoptosis |
| WP:WP3872 | 1.1681834295e-06 | 0.6 | BAK1 BCL2L15 BAX | Regulation of apoptosis by parathyroid hormone related protein |
| WP:WP4864 | 1.37419225557e-06 | 0.6 | BBC3 BCL2L11 BAX | Host pathogen interaction of human coronaviruses apoptosis |
| GO:1905898 | 1.66236029818e-06 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of response to endoplasmic reticulum stress |
| GO:1900101 | 1.96449993261e-06 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of endoplasmic reticulum unfolded protein response |
| WP:WP4396 | 2.30427245628e-06 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Nonalcoholic fatty liver disease |
| GO:0090199 | 7.73614931468e-06 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of release of cytochrome c from mitochondria |
| REAC:R-HSA-109581 | 1.29159517875e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Apoptosis |
| WP:WP3611 | 1.48411025729e-05 | 0.6 | BAK1 BCL2L11 BAX | Photodynamic therapy induced AP 1 survival signaling |
| GO:0001836 | 1.78207144985e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | release of cytochrome c from mitochondria |
| GO:0070059 | 2.34110134044e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| REAC:R-HSA-5357801 | 2.41837850166e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Programmed Cell Death |
| KEGG:01524 | 5.07328889026e-05 | 0.6 | BAX BAK1 BBC3 | Platinum drug resistance |
| GO:0030968 | 5.18179525184e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | endoplasmic reticulum unfolded protein response |
| GO:0010822 | 6.39580887555e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of mitochondrion organization |
| GO:1905897 | 6.84426164966e-05 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of response to endoplasmic reticulum stress |
| GO:0034620 | 0.000113331695245 | 0.8 | BAX BAK1 BCL2L11 BBC3 | cellular response to unfolded protein |
| REAC:R-HSA-111457 | 0.000151950811602 | 0.4 | BAK1 BAX | Release of apoptotic factors from the mitochondria |
| GO:0097136 | 0.000158467845213 | 0.6 | BAK1 BCL2L11 BAX | Bcl-2 family protein complex |
| GO:0008637 | 0.000186904603412 | 0.8 | BAX BAK1 BCL2L11 BBC3 | apoptotic mitochondrial changes |
| KEGG:05200 | 0.000202734552549 | 0.8 | BAX BAK1 BCL2L11 BBC3 | Pathways in cancer |
| GO:0035967 | 0.000207211791955 | 0.8 | BAX BAK1 BCL2L11 BBC3 | cellular response to topologically incorrect protein |
| KEGG:05162 | 0.00028582601872 | 0.6 | BAX BAK1 BBC3 | Measles |
| GO:2001056 | 0.000334585912591 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of cysteine-type endopeptidase activity |
| WP:WP4630 | 0.000360939526928 | 0.6 | BAX BAK1 BBC3 | Measles virus infection |
| GO:0006986 | 0.000382257669512 | 0.8 | BAX BAK1 BCL2L11 BBC3 | response to unfolded protein |
| REAC:R-HSA-111453 | 0.000546723465219 | 0.4 | BBC3 BCL2L11 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| GO:0010950 | 0.000601631697955 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of endopeptidase activity |
| GO:0035966 | 0.000649914918254 | 0.8 | BAX BAK1 BCL2L11 BBC3 | response to topologically incorrect protein |
| GO:0010952 | 0.000812283184782 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of peptidase activity |
| GO:0010821 | 0.000872617123619 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of mitochondrion organization |
| KEGG:05169 | 0.000875882872118 | 0.6 | BAK1 BCL2L11 BAX | Epstein-Barr virus infection |
| WP:WP3982 | 0.00100346979189 | 0.4 | BBC3 BAX | miRNA regulation of p53 pathway in prostate cancer |
| WP:WP1742 | 0.00100346979189 | 0.4 | BBC3 BAX | TP53 network |
| WP:WP2507 | 0.00100346979189 | 0.4 | BAK1 BAX | Nanomaterial induced apoptosis |
| GO:0032469 | 0.00109385703544 | 0.6 | BAX BAK1 BBC3 | endoplasmic reticulum calcium ion homeostasis |
| WP:WP4925 | 0.00135500760343 | 0.4 | BBC3 BCL2L11 | Unfolded protein response |
| WP:WP3613 | 0.00175902717245 | 0.4 | BBC3 BCL2L11 | Photodynamic therapy induced unfolded protein response |
| REAC:R-HSA-9614657 | 0.0018206657072 | 0.4 | BBC3 BCL2L11 | FOXO-mediated transcription of cell death genes |
| GO:2000116 | 0.0018342008752 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of cysteine-type endopeptidase activity |
| WP:WP4838 | 0.00190535175424 | 0.4 | BAK1 BAX | Regucalcin in proximal tubule epithelial kidney cells |
| REAC:R-HSA-111471 | 0.00206313859056 | 0.4 | BAK1 BAX | Apoptotic factor-mediated response |
| GO:0031334 | 0.00230628014448 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of protein-containing complex assembly |
| KEGG:05216 | 0.00253895212354 | 0.4 | BAK1 BAX | Thyroid cancer |
| REAC:R-HSA-6803204 | 0.00259338296865 | 0.4 | BBC3 BAX | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| GO:0005741 | 0.00326030759216 | 0.8 | BAX BAK1 BCL2L11 BBC3 | mitochondrial outer membrane |
| WP:WP3614 | 0.00328532749654 | 0.4 | BAK1 BAX | Photodynamic therapy induced HIF 1 survival signaling |
| GO:0034976 | 0.0035170104576 | 0.8 | BAX BAK1 BCL2L11 BBC3 | response to endoplasmic reticulum stress |
| REAC:R-HSA-5620971 | 0.00383489202506 | 0.4 | BAK1 BAX | Pyroptosis |
| WP:WP1971 | 0.00456408083355 | 0.4 | BBC3 BAX | Integrated cancer pathway |
| GO:0097145 | 0.00468200720083 | 0.4 | BAK1 BAX | BAK complex |
| GO:0052548 | 0.00469791606681 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of endopeptidase activity |
| GO:0031968 | 0.00480818953079 | 0.8 | BAX BAK1 BCL2L11 BBC3 | organelle outer membrane |
| GO:0019867 | 0.00492038984684 | 0.8 | BAX BAK1 BCL2L11 BBC3 | outer membrane |
| KEGG:05213 | 0.00598637208626 | 0.4 | BAK1 BAX | Endometrial cancer |
| REAC:R-HSA-114452 | 0.0065872694687 | 0.4 | BBC3 BCL2L11 | Activation of BH3-only proteins |
| KEGG:05217 | 0.00670143785748 | 0.4 | BAK1 BAX | Basal cell carcinoma |
| GO:0052547 | 0.00729542990987 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of peptidase activity |
| WP:WP3959 | 0.00774618498599 | 0.4 | BAK1 BAX | DNA IR double strand breaks and cellular response via ATM |
| KEGG:05218 | 0.00852542753416 | 0.4 | BAK1 BAX | Melanoma |
| KEGG:04115 | 0.00908648748607 | 0.4 | BBC3 BAX | p53 signaling pathway |
| WP:WP4155 | 0.00931707261303 | 0.4 | BAK1 BAX | Endometrial cancer |
| WP:WP5087 | 0.0098916730515 | 0.6 | BAX BAK1 BBC3 | Pleural mesothelioma |
| GO:2001244 | 0.0102064666638 | 0.6 | BBC3 BCL2L11 BAX | positive regulation of intrinsic apoptotic signaling pathway |
| KEGG:05223 | 0.0102617382696 | 0.4 | BAK1 BAX | Non-small cell lung cancer |
| KEGG:05214 | 0.0102617382696 | 0.4 | BAK1 BAX | Glioma |
| WP:WP4685 | 0.010328593539 | 0.4 | BAK1 BAX | Melanoma |
| REAC:R-HSA-5633008 | 0.0106339701454 | 0.4 | BBC3 BAX | TP53 Regulates Transcription of Cell Death Genes |
| GO:0097193 | 0.0108428082614 | 0.8 | BAX BAK1 BCL2L11 BBC3 | intrinsic apoptotic signaling pathway |
| KEGG:05212 | 0.0115077320087 | 0.4 | BAK1 BAX | Pancreatic cancer |
| WP:WP707 | 0.0121292354685 | 0.4 | BBC3 BAX | DNA damage response |
| WP:WP1530 | 0.0121292354685 | 0.4 | BBC3 BAX | miRNA regulation of DNA damage response |
| KEGG:05220 | 0.012157220678 | 0.4 | BAK1 BAX | Chronic myeloid leukemia |
| KEGG:01521 | 0.012157220678 | 0.4 | BAX BCL2L11 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4255 | 0.0128896073912 | 0.4 | BAK1 BAX | Non small cell lung cancer |
| KEGG:05222 | 0.0164241113683 | 0.4 | BAK1 BAX | Small cell lung cancer |
| GO:2001233 | 0.0169288695151 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of apoptotic signaling pathway |
| WP:WP4806 | 0.0179319533427 | 0.4 | BAX BCL2L11 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4963 | 0.0188521857166 | 0.4 | BBC3 BAX | p53 transcriptional gene network |
| WP:WP4263 | 0.0188521857166 | 0.4 | BAK1 BAX | Pancreatic adenocarcinoma pathway |
| GO:0045862 | 0.0196468946878 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of proteolysis |
| GO:0006919 | 0.019918492568 | 0.6 | BBC3 BCL2L11 BAX | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| REAC:R-HSA-5218859 | 0.0208015819243 | 0.4 | BAK1 BAX | Regulated Necrosis |
| WP:WP4658 | 0.0227605362571 | 0.4 | BAK1 BAX | Small cell lung cancer |
| WP:WP5090 | 0.0227605362571 | 0.4 | BAK1 BAX | Complement system in neuronal development and plasticity |
| REAC:R-HSA-9614085 | 0.0266933781073 | 0.4 | BBC3 BCL2L11 | FOXO-mediated transcription |
| GO:0010248 | 0.0280843539964 | 0.4 | BAK1 BAX | establishment or maintenance of transmembrane electrochemical gradient |
| WP:WP5322 | 0.0281562480757 | 0.4 | BAX BCL2L11 | CKAP4 signaling pathway map |
| KEGG:05224 | 0.035751387428 | 0.4 | BAK1 BAX | Breast cancer |
| GO:0043254 | 0.0368664091126 | 0.8 | BAX BAK1 BCL2L11 BBC3 | regulation of protein-containing complex assembly |
| KEGG:05160 | 0.0380272112444 | 0.4 | BAK1 BAX | Hepatitis C |
| KEGG:05226 | 0.0380272112444 | 0.4 | BAK1 BAX | Gastric cancer |
| GO:0051345 | 0.0400283267175 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of hydrolase activity |
| KEGG:04932 | 0.0427854405203 | 0.4 | BAX BCL2L11 | Non-alcoholic fatty liver disease |
| KEGG:05164 | 0.0458988724567 | 0.4 | BAK1 BAX | Influenza A |
| KEGG:05206 | 0.0484667159694 | 0.4 | BAK1 BCL2L11 | MicroRNAs in cancer |
| GO:0043065 | 0.0494529381498 | 0.8 | BAX BAK1 BCL2L11 BBC3 | positive regulation of apoptotic process |
| CORUM:3492 | 0.0498708842806 | 0.2 | BAX | BAX homo-oligomer complex |
| CORUM:2000 | 0.0498708842806 | 0.2 | BAX | BAX homo-oligomer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BCL2L11 | BAX | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BAX | BAK1 | 0.987 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BBC3 | BAX | 0.966 | bioplex_WMM bioplex3_WMM WMM_only | |
| BBC3 | BAK1 | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | |
| BCL2L15 | BAX | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BCL2L11 | BBC3 | 0.956 | bioplex_WMM bioplex3_WMM WMM_only | |
| BCL2L11 | BAK1 | 0.947 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes