hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07558.1

Complex Portal: CPX-12262

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ATP6AP2	Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]	5	UniProt NCBI
KIAA2013	Uncharacterized protein KIAA2013	3	UniProt NCBI
AQP5	Aquaporin-5 (AQP-5)	5	UniProt NCBI
ATP6V0A2	V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)	5	UniProt NCBI
ATP6V0E1	V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)	5	UniProt NCBI
TCIRG1	V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)	5	UniProt NCBI
ATP6V0A1	V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	5	UniProt NCBI
ATP6V0D1	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04966	1.67476842892e-11	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Collecting duct acid secretion
GO:0007035	3.89074914022e-11	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	vacuolar acidification
REAC:R-HSA-917977	2.10053178544e-10	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Transferrin endocytosis and recycling
REAC:R-HSA-77387	2.10053178544e-10	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Insulin receptor recycling
REAC:R-HSA-1222556	3.62962999131e-10	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	ROS and RNS production in phagocytes
GO:0051452	4.63651494015e-10	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	intracellular pH reduction
KEGG:05110	6.05801827724e-10	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Vibrio cholerae infection
KEGG:04721	2.70109765361e-09	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Synaptic vesicle cycle
GO:1902600	2.98439300905e-09	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	proton transmembrane transport
KEGG:05120	3.47446424753e-09	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Epithelial cell signaling in Helicobacter pylori infection
KEGG:05323	5.14838107496e-09	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Rheumatoid arthritis
GO:0051453	5.15087991013e-09	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	regulation of intracellular pH
REAC:R-HSA-917937	5.5319301391e-09	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Iron uptake and transport
GO:0030641	6.32339020868e-09	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	regulation of cellular pH
GO:0006885	8.49328317467e-09	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	regulation of pH
GO:0016471	1.32402198725e-08	0.625	ATP6AP2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0A2	vacuolar proton-transporting V-type ATPase complex
REAC:R-HSA-74752	1.37500207064e-08	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Signaling by Insulin receptor
GO:0033176	1.69151611321e-08	0.625	ATP6AP2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0A2	proton-transporting V-type ATPase complex
KEGG:00190	1.01431390851e-07	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Oxidative phosphorylation
KEGG:04145	1.51097447712e-07	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Phagosome
GO:0030670	4.2623579786e-07	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	phagocytic vesicle membrane
REAC:R-HSA-983712	4.73341010218e-07	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Ion channel transport
GO:0016469	5.4396869584e-07	0.625	ATP6AP2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0A2	proton-transporting two-sector ATPase complex
KEGG:05165	8.40198354629e-06	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Human papillomavirus infection
REAC:R-HSA-382551	1.28097092874e-05	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 AQP5	Transport of small molecules
KEGG:04142	1.61290616088e-05	0.5	ATP6V0A2 ATP6V0D1 TCIRG1 ATP6V0A1	Lysosome
GO:0045335	1.63146572742e-05	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	phagocytic vesicle
GO:0000220	2.15253635486e-05	0.375	ATP6AP2 ATP6V0A1 ATP6V0D1	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0033179	2.15253635486e-05	0.375	ATP6AP2 ATP6V0A1 ATP6V0D1	proton-transporting V-type ATPase, V0 domain
KEGG:05152	3.21066744491e-05	0.5	ATP6V0A2 ATP6V0D1 TCIRG1 ATP6V0A1	Tuberculosis
GO:0030003	0.000115012597496	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	intracellular monoatomic cation homeostasis
GO:0006873	0.000121890996439	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	intracellular monoatomic ion homeostasis
GO:0005765	0.000158682935794	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	lysosomal membrane
GO:0098852	0.000158682935794	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	lytic vacuole membrane
GO:1904949	0.000198131471969	0.625	ATP6AP2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0A2	ATPase complex
GO:0055080	0.000207902922888	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic cation homeostasis
GO:0010008	0.000211590156107	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	endosome membrane
GO:0050801	0.000230851778846	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic ion homeostasis
REAC:R-HSA-9006934	0.000244129342009	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Signaling by Receptor Tyrosine Kinases
GO:0005774	0.000251548604579	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	vacuolar membrane
GO:0030666	0.000253892552089	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	endocytic vesicle membrane
REAC:R-HSA-168249	0.000265284467152	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	Innate Immune System
GO:0030659	0.000352041620405	0.875	ATP6V0E1 TCIRG1 ATP6V0D1 ATP6V0A2 ATP6V0A1 AQP5 ATP6AP2	cytoplasmic vesicle membrane
GO:0012506	0.000393234366164	0.875	ATP6V0E1 TCIRG1 ATP6V0D1 ATP6V0A2 ATP6V0A1 AQP5 ATP6AP2	vesicle membrane
GO:0055082	0.000525326728956	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	intracellular chemical homeostasis
REAC:R-HSA-9639288	0.000529728773758	0.375	ATP6V0E1 TCIRG1 ATP6V0D1	Amino acids regulate mTORC1
GO:0098662	0.00060950234597	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	inorganic cation transmembrane transport
GO:0098655	0.000646167960847	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic cation transmembrane transport
GO:0098660	0.000997427828746	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	inorganic ion transmembrane transport
GO:0033177	0.00118146610329	0.375	ATP6AP2 ATP6V0A1 ATP6V0D1	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0034220	0.00149443373947	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic ion transmembrane transport
GO:0019725	0.00151336978372	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	cellular homeostasis
GO:0006812	0.00311274701697	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic cation transport
GO:0030139	0.00425417179066	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	endocytic vesicle
GO:0048878	0.004352025571	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	chemical homeostasis
GO:0000323	0.00463367841136	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	lytic vacuole
GO:0005764	0.00463367841136	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	lysosome
GO:0007042	0.00519447563198	0.375	ATP6AP2 TCIRG1 ATP6V0A1	lysosomal lumen acidification
GO:0016236	0.00586429352642	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	macroautophagy
GO:0006811	0.00747996902833	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	monoatomic ion transport
GO:0005773	0.00822555362628	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	vacuole
GO:0035751	0.0108360428077	0.375	ATP6AP2 TCIRG1 ATP6V0A1	regulation of lysosomal lumen pH
REAC:R-HSA-168256	0.0113619114179	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	Immune System
KEGG:01100	0.0120498549077	0.625	ATP6V0A2 ATP6V0A1 ATP6V0D1 TCIRG1 ATP6V0E1	Metabolic pathways
REAC:R-HSA-9711097	0.0128981453269	0.375	ATP6V0E1 TCIRG1 ATP6V0D1	Cellular response to starvation
GO:0005768	0.0164390141855	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	endosome
GO:0016241	0.0229851818624	0.5	ATP6V0A2 ATP6V0D1 ATP6V0A1 ATP6V0E1	regulation of macroautophagy
GO:0055085	0.0268181507956	0.75	ATP6V0E1 TCIRG1 ATP6V0A2 ATP6V0A1 ATP6V0D1 ATP6AP2	transmembrane transport

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
ATP6V0A1	ATP6V0D1	1.0	0.412	structurally_consistent (P27449)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction
ATP6V0A2	ATP6V0D1	0.999	0.138		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TCIRG1	ATP6V0D1	0.999	0.254	structurally_consistent (P27449)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ATP6V0A2	ATP6V0A1	0.999	0.094	mutually_exclusive (P27449)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
ATP6V0A2	ATP6AP2	0.999	0.06	structurally_consistent (P27449) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
ATP6V0A1	ATP6AP2	0.998	0.078	structurally_consistent (P27449)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM
KIAA2013	ATP6AP2	0.998	0.142		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KIAA2013	ATP6V0A2	0.998	0.07	mutually_exclusive (P27449)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TCIRG1	ATP6AP2	0.997	0.048	structurally_consistent (P27449)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TCIRG1	ATP6V0A1	0.994	0.106		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
KIAA2013	ATP6V0A1	0.994	0.07	mutually_exclusive (P27449)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TCIRG1	ATP6V0A2	0.992	0.062	mutually_exclusive (P27449)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0D1	ATP6AP2	0.991	0.194	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
KIAA2013	TCIRG1	0.983	0.08	mutually_exclusive (P27449)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
KIAA2013	ATP6V0D1	0.974	0.066		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ATP6V0E1	ATP6V0A2	0.966			bioplex3_HEK293 bioplex ()
ATP6V0A2	AQP5	0.954			bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0E1	ATP6AP2	0.91			bioplex3_HEK293 bioplex ()
ATP6V0E1	ATP6V0D1	0.902			bioplex3_HEK293 bioplex ()
ATP6V0E1	ATP6V0A1	0.89			bioplex3_HEK293 bioplex ()
AQP5	ATP6V0A1	0.84			bioplex3_WMM bioplex3_HCT116 WMM_only
AQP5	ATP6V0D1	0.033			bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
ATP6AP2	huMAP3_04131.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08182.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
KIAA2013	huMAP3_00308.1 huMAP3_05318.1 huMAP3_07558.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_10511.1 huMAP3_10516.1
AQP5	huMAP3_01575.1 huMAP3_03999.1 huMAP3_05374.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_11642.1 huMAP3_11743.1 huMAP3_12042.1 huMAP3_12056.1
ATP6V0A2	huMAP3_01575.1 huMAP3_02239.1 huMAP3_03999.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0E1	huMAP3_01538.1 huMAP3_03999.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13872.1
TCIRG1	huMAP3_01038.1 huMAP3_01501.1 huMAP3_02239.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09324.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13060.1 huMAP3_13872.1
ATP6V0A1	huMAP3_01609.1 huMAP3_04131.1 huMAP3_05444.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08381.1 huMAP3_08751.1 huMAP3_09440.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0D1	huMAP3_02239.1 huMAP3_05444.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08381.1 huMAP3_08621.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07558.1

Complex Portal: CPX-12262