hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07561.1

Complex Portal: CPX-21746

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
SAP18	Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)	5	UniProt NCBI
SNIP1	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	5	UniProt NCBI
CCDC9	Coiled-coil domain-containing protein 9	4	UniProt NCBI
MAGOH	Protein mago nashi homolog	5	UniProt NCBI
EIF4A3	Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]	5	UniProt NCBI
PNN	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	5	UniProt NCBI
RBM8A	RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035145	1.00249058106e-12	0.857142857143	EIF4A3 CCDC9 SAP18 PNN RBM8A MAGOH	exon-exon junction complex
REAC:R-HSA-72163	8.42500920507e-09	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	mRNA Splicing - Major Pathway
KEGG:03015	9.08932641893e-09	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	mRNA surveillance pathway
REAC:R-HSA-72172	1.03682214592e-08	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	mRNA Splicing
KEGG:03013	1.54636599111e-08	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	Nucleocytoplasmic transport
CORUM:754	2.80877722849e-08	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14)
CORUM:744	2.80877722849e-08	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:740	2.80877722849e-08	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:769	2.80877722849e-08	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
REAC:R-HSA-72203	5.49269500155e-08	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	Processing of Capped Intron-Containing Pre-mRNA
CORUM:755	7.02050133195e-08	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM)
CORUM:6742	1.4038119659e-07	0.428571428571	RBM8A MAGOH EIF4A3	SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex
CORUM:785	2.45616649736e-07	0.428571428571	RBM8A MAGOH EIF4A3	Exon junction complex
CORUM:1181	2.57078286488e-06	0.571428571429	PNN RBM8A MAGOH EIF4A3	C complex spliceosome
GO:0000398	1.18487839663e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	mRNA splicing, via spliceosome
GO:0000377	1.18487839663e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000375	1.29667426464e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	RNA splicing, via transesterification reactions
REAC:R-HSA-8953854	1.34047597764e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	Metabolism of RNA
CORUM:763	2.05265451394e-05	0.285714285714	RBM8A MAGOH	Y14-Magoh complex
CORUM:773	2.05265451394e-05	0.285714285714	RBM8A MAGOH	Y14-Magoh complex
GO:0006397	4.76399408567e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	mRNA processing
CORUM:1293	6.1565588648e-05	0.285714285714	RBM8A MAGOH	IPO13-RBM8A-MAGOH complex
GO:0008380	8.11796570198e-05	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	RNA splicing
GO:0005681	0.000206894724857	0.714285714286	SNIP1 PNN RBM8A MAGOH EIF4A3	spliceosomal complex
REAC:R-HSA-72187	0.0003384553812	0.428571428571	RBM8A MAGOH EIF4A3	mRNA 3'-end processing
REAC:R-HSA-73856	0.000511465276813	0.428571428571	RBM8A MAGOH EIF4A3	RNA Polymerase II Transcription Termination
GO:2000622	0.000554182028596	0.428571428571	RBM8A MAGOH EIF4A3	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0140513	0.000698274170384	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	nuclear protein-containing complex
REAC:R-HSA-159236	0.000704018847769	0.428571428571	RBM8A MAGOH EIF4A3	Transport of Mature mRNA derived from an Intron-Containing Transcript
GO:0016071	0.000979013104412	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	mRNA metabolic process
REAC:R-HSA-72202	0.00101516292409	0.428571428571	RBM8A MAGOH EIF4A3	Transport of Mature Transcript to Cytoplasm
KEGG:03040	0.00108816732534	0.428571428571	RBM8A MAGOH EIF4A3	Spliceosome
GO:0071013	0.00202210317171	0.571428571429	PNN RBM8A MAGOH EIF4A3	catalytic step 2 spliceosome
CORUM:351	0.00286422017167	0.428571428571	RBM8A MAGOH EIF4A3	Spliceosome
REAC:R-HSA-927802	0.00306472559835	0.428571428571	RBM8A MAGOH EIF4A3	Nonsense-Mediated Decay (NMD)
REAC:R-HSA-975957	0.00306472559835	0.428571428571	RBM8A MAGOH EIF4A3	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
HPA:0570791	0.00308516623972	0.857142857143	EIF4A3 SNIP1 CCDC9 PNN RBM8A SAP18	testis; round or early spermatids[>=Low]
HPA:0130202	0.00318818628688	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	colon; endothelial cells[>=Medium]
HPA:0460672	0.00330462389769	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	skin 1; melanocytes[>=Medium]
HPA:0570772	0.00351231978593	0.571428571429	SNIP1 RBM8A EIF4A3 PNN	testis; peritubular cells[>=Medium]
GO:0003723	0.00365068293209	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	RNA binding
HPA:0080122	0.00518153953053	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	caudate; glial cells[>=Medium]
HPA:0010011	0.00535028790023	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	adipose tissue; adipocytes[>=Low]
HPA:0010000	0.00535028790023	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	adipose tissue
HPA:0301372	0.00580454207605	0.714285714286	PNN RBM8A EIF4A3 SAP18 CCDC9	lung; alveolar cells type II[>=Medium]
HP:0009486	0.00598974417902	0.285714285714	RBM8A EIF4A3	Radial deviation of the hand
HPA:0620222	0.00635889715139	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	vagina; squamous epithelial cells[>=Medium]
GO:0006396	0.00685712478237	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	RNA processing
HPA:0570801	0.00793021341268	0.857142857143	EIF4A3 SNIP1 CCDC9 PNN RBM8A SAP18	testis; sertoli cells[>=Low]
HPA:0570773	0.0079666924392	0.428571428571	SNIP1 EIF4A3 RBM8A	testis; peritubular cells[High]
HPA:0570813	0.00903917598725	0.714285714286	SNIP1 PNN RBM8A CCDC9 EIF4A3	testis; spermatogonia cells[High]
REAC:R-HSA-9010553	0.00943980481067	0.428571428571	RBM8A MAGOH EIF4A3	Regulation of expression of SLITs and ROBOs
HPA:0080123	0.0105779971796	0.571428571429	RBM8A EIF4A3 SAP18 MAGOH	caudate; glial cells[High]
HPA:0570771	0.0113999127794	0.571428571429	SNIP1 RBM8A EIF4A3 PNN	testis; peritubular cells[>=Low]
HPA:0100122	0.0121923236822	0.857142857143	EIF4A3 SNIP1 MAGOH PNN RBM8A SAP18	cerebral cortex; glial cells[>=Medium]
HPA:0600223	0.0128006144006	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	tonsil; squamous epithelial cells[High]
HPA:0080121	0.0135544012025	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	caudate; glial cells[>=Low]
HPA:0090183	0.014905435517	0.571428571429	PNN RBM8A MAGOH EIF4A3	cerebellum; cells in granular layer[High]
HPA:0100201	0.0154029798657	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	cerebral cortex; endothelial cells[>=Low]
HPA:0301371	0.0166031206858	0.714285714286	PNN RBM8A EIF4A3 SAP18 CCDC9	lung; alveolar cells type II[>=Low]
GO:0000184	0.0182422971773	0.428571428571	RBM8A MAGOH EIF4A3	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
HPA:0320102	0.0187790608236	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	nasopharynx; respiratory epithelial cells[>=Medium]
REAC:R-HSA-376176	0.0190108932455	0.428571428571	RBM8A MAGOH EIF4A3	Signaling by ROBO receptors
HPA:0570811	0.0191101015746	0.857142857143	EIF4A3 SNIP1 CCDC9 PNN RBM8A SAP18	testis; spermatogonia cells[>=Low]
WP:WP5362	0.0207233783056	0.285714285714	MAGOH EIF4A3	TAR syndrome
HPA:0100121	0.0225892797348	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	cerebral cortex; glial cells[>=Low]
HPA:0570792	0.02454917637	0.714285714286	SNIP1 PNN RBM8A SAP18 EIF4A3	testis; round or early spermatids[>=Medium]
HPA:0600222	0.0259260211515	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	tonsil; squamous epithelial cells[>=Medium]
HPA:0530712	0.0280168441993	0.857142857143	EIF4A3 CCDC9 SAP18 PNN RBM8A MAGOH	spleen; cells in red pulp[>=Medium]
HPA:0570781	0.0284194718187	0.714285714286	PNN RBM8A EIF4A3 SAP18 CCDC9	testis; preleptotene spermatocytes[>=Low]
HPA:0190222	0.0294038225527	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	esophagus; squamous epithelial cells[>=Medium]
GO:1903503	0.0294899169624	0.285714285714	RBM8A MAGOH	ATPase inhibitor complex
GO:1990501	0.0294899169624	0.285714285714	RBM8A MAGOH	exon-exon junction subcomplex mago-y14
HPA:0270351	0.0313594015773	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	kidney; cells in glomeruli[>=Low]
HPA:0320103	0.0318090001371	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	nasopharynx; respiratory epithelial cells[High]
HPA:0301362	0.0322525779597	0.571428571429	PNN RBM8A SAP18 EIF4A3	lung; alveolar cells type I[>=Medium]
HPA:0570802	0.0328468260001	0.714285714286	SNIP1 PNN RBM8A SAP18 EIF4A3	testis; sertoli cells[>=Medium]
HPA:0570793	0.0331675907289	0.571428571429	SNIP1 RBM8A EIF4A3 PNN	testis; round or early spermatids[High]
HPA:0510000	0.0340880803824	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	soft tissue 2
HPA:0060103	0.0350017722259	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	bronchus; respiratory epithelial cells[High]
HPA:0180053	0.0350017722259	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	epididymis; glandular cells[High]
HPA:0100133	0.0357100891892	0.714285714286	PNN RBM8A EIF4A3 SAP18 MAGOH	cerebral cortex; neuronal cells[High]
HPA:0460671	0.0393979445648	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	skin 1; melanocytes[>=Low]
HPA:0350472	0.041116897218	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	pancreas; exocrine glandular cells[>=Medium]
HPA:0500000	0.0416022514789	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	soft tissue 1
HPA:0490000	0.0470701914608	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	smooth muscle
HPA:0490691	0.0470701914608	1.0	EIF4A3 SNIP1 CCDC9 SAP18 PNN RBM8A MAGOH	smooth muscle; smooth muscle cells[>=Low]
GO:0000381	0.0473277551461	0.428571428571	RBM8A SAP18 MAGOH	regulation of alternative mRNA splicing, via spliceosome
HPA:0250122	0.0487753888962	0.714285714286	SNIP1 PNN RBM8A SAP18 EIF4A3	hippocampus; glial cells[>=Medium]
HP:0006492	0.0497326121949	0.285714285714	RBM8A EIF4A3	Aplasia/Hypoplasia of the fibula

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CCDC9	EIF4A3	1.0	0.1	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein ()
MAGOH	RBM8A	1.0		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM
RBM8A	CCDC9	0.999	0.184		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein ()
PNN	RBM8A	0.999	0.874	mutually_exclusive (P38919)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM
PNN	CCDC9	0.999	0.158	mutually_exclusive (P38919)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein ()
PNN	SAP18	0.999		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
MAGOH	CCDC9	0.998		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CCDC9	SAP18	0.998		structurally_consistent (P38919)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
EIF4A3	SNIP1	0.998	0.506		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PNN	EIF4A3	0.996	0.896	mutually_exclusive (O00422) structurally_consistent (dimer)	hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM
MAGOH	SNIP1	0.99			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PNN	SNIP1	0.989	0.442		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF4A3	SAP18	0.987		structurally_consistent (dimer)	hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
CCDC9	SNIP1	0.987	0.076		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RBM8A	SNIP1	0.985	0.494		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAGOH	PNN	0.982			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM
MAGOH	EIF4A3	0.978		structurally_consistent (dimer)	hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
RBM8A	SAP18	0.972			hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
RBM8A	EIF4A3	0.951	0.89	structurally_consistent (dimer)	hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
MAGOH	SAP18	0.95		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
SNIP1	SAP18	0.194			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116

Related Complexes

Genename	Complexes
SAP18	huMAP3_05319.1 huMAP3_05722.1 huMAP3_05740.1 huMAP3_06219.1 huMAP3_07248.1 huMAP3_07561.1 huMAP3_08302.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08769.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
SNIP1	huMAP3_03772.1 huMAP3_06391.1 huMAP3_06799.1 huMAP3_07248.1 huMAP3_07561.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10139.1 huMAP3_10564.1 huMAP3_11073.1
CCDC9	huMAP3_01312.1 huMAP3_01567.1 huMAP3_02633.1 huMAP3_04872.1 huMAP3_05069.1 huMAP3_05740.1 huMAP3_05846.1 huMAP3_06219.1 huMAP3_06799.1 huMAP3_07267.1 huMAP3_07561.1 huMAP3_07674.1 huMAP3_08186.1 huMAP3_08302.1 huMAP3_09101.1 huMAP3_09226.1 huMAP3_09552.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
MAGOH	huMAP3_00837.1 huMAP3_04073.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07208.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
EIF4A3	huMAP3_01312.1 huMAP3_02633.1 huMAP3_04872.1 huMAP3_05069.1 huMAP3_05740.1 huMAP3_05846.1 huMAP3_06799.1 huMAP3_07561.1 huMAP3_07674.1 huMAP3_08186.1 huMAP3_08302.1 huMAP3_09101.1 huMAP3_09226.1 huMAP3_09552.1 huMAP3_09621.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_12548.1
PNN	huMAP3_00837.1 huMAP3_01312.1 huMAP3_05740.1 huMAP3_06391.1 huMAP3_06799.1 huMAP3_07098.1 huMAP3_07267.1 huMAP3_07561.1 huMAP3_07674.1 huMAP3_08082.1 huMAP3_08302.1 huMAP3_08344.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
RBM8A	huMAP3_00837.1 huMAP3_01288.1 huMAP3_03123.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09149.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07561.1

Complex Portal: CPX-21746