hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07567.1
Complex Portal: CPX-22668
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIGH | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H) | 5 | UniProt NCBI |
| PIGQ | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) | 5 | UniProt NCBI |
| CYP4F11 | Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78) | 5 | UniProt NCBI |
| KCNH2 | Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1) | 5 | UniProt NCBI |
| PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P) | 5 | UniProt NCBI |
| SLC4A11 | Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) | 5 | UniProt NCBI |
| PIGA | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A) | 5 | UniProt NCBI |
| AREL1 | Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1) | 5 | UniProt NCBI |
| ENTREP3 | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | 5 | UniProt NCBI |
| IL18RAP | Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:118 | 1.68385473419e-08 | 0.3 | PIGH PIGA PIGQ | GPI-GnT activity complex |
| GO:0000506 | 2.76191861336e-08 | 0.4 | PIGH PIGA PIGP PIGQ | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
| KEGG:00563 | 3.31185850848e-08 | 0.4 | PIGH PIGA PIGP PIGQ | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
| REAC:R-HSA-162710 | 1.22191993529e-05 | 0.3 | PIGH PIGA PIGP | Synthesis of glycosylphosphatidylinositol (GPI) |
| GO:0006506 | 5.83308429282e-05 | 0.4 | PIGH PIGA PIGP PIGQ | GPI anchor biosynthetic process |
| GO:0006505 | 6.94186470066e-05 | 0.4 | PIGH PIGA PIGP PIGQ | GPI anchor metabolic process |
| REAC:R-HSA-163125 | 0.0023802481167 | 0.3 | PIGH PIGA PIGP | Post-translational modification: synthesis of GPI-anchored proteins |
| GO:0009247 | 0.00246977648377 | 0.4 | PIGH PIGA PIGP PIGQ | glycolipid biosynthetic process |
| GO:0006497 | 0.00366675599097 | 0.4 | PIGH PIGA PIGP PIGQ | protein lipidation |
| GO:0042158 | 0.00390203518198 | 0.4 | PIGH PIGA PIGP PIGQ | lipoprotein biosynthetic process |
| HP:0010841 | 0.00797162805718 | 0.3 | PIGQ PIGA PIGP | Multifocal epileptiform discharges |
| GO:0042157 | 0.00852338417127 | 0.4 | PIGH PIGA PIGP PIGQ | lipoprotein metabolic process |
| HP:0020221 | 0.00966100706188 | 0.3 | PIGQ PIGA PIGP | Clonic seizure |
| GO:0006664 | 0.00989343452758 | 0.4 | PIGH PIGA PIGP PIGQ | glycolipid metabolic process |
| GO:1903509 | 0.00989343452758 | 0.4 | PIGH PIGA PIGP PIGQ | liposaccharide metabolic process |
| HP:0004379 | 0.0232586243067 | 0.3 | PIGH PIGA PIGQ | Abnormality of alkaline phosphatase level |
| GO:0140534 | 0.0255498654968 | 0.4 | PIGH PIGA PIGP PIGQ | endoplasmic reticulum protein-containing complex |
| GO:0006661 | 0.0275647597214 | 0.4 | PIGH PIGA PIGP PIGQ | phosphatidylinositol biosynthetic process |
| HP:0011190 | 0.0374294407319 | 0.2 | PIGQ PIGP | Uni- and bilateral multifocal epileptiform discharges |
| GO:0046467 | 0.0394688826733 | 0.4 | PIGH PIGA PIGP PIGQ | membrane lipid biosynthetic process |
| HP:0011185 | 0.0408686292444 | 0.3 | PIGQ PIGA PIGP | EEG with focal epileptiform discharges |
| HP:0012554 | 0.0431720528278 | 0.2 | PIGQ PIGP | Absent thumbnail |
| CORUM:6571 | 0.0499436884912 | 0.1 | KCNH2 | KCNE1-KCNH2 complex |
| CORUM:6578 | 0.0499436884912 | 0.1 | KCNH2 | KCNE2-KCNH2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIGP | PIGH | 1.0 |
mutually_exclusive (P37287)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KCNH2 | PIGH | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PIGH | SLC4A11 | 0.997 | 0.136 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PIGH | CYP4F11 | 0.997 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PIGH | ENTREP3 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PIGA | PIGH | 0.992 | 0.11 |
mutually_exclusive (P57054)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PIGH | PIGQ | 0.99 | 0.094 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PIGH | AREL1 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IL18RAP | PIGH | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ENTREP3 | AREL1 | 0.975 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGA | PIGP | 0.97 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIGA | IL18RAP | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PIGA | AREL1 | 0.965 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGA | ENTREP3 | 0.963 | bioplex () bioplex_WMM bioplex3_WMM | ||
| KCNH2 | SLC4A11 | 0.902 | bioplex3_WMM WMM_only | ||
| KCNH2 | CYP4F11 | 0.902 | bioplex3_WMM WMM_only | ||
| KCNH2 | PIGP | 0.902 | bioplex3_WMM WMM_only | ||
| CYP4F11 | SLC4A11 | 0.902 | 0.076 | bioplex3_WMM WMM_only | |
| PIGP | SLC4A11 | 0.902 | bioplex3_WMM WMM_only | ||
| PIGP | CYP4F11 | 0.902 | bioplex3_WMM WMM_only | ||
| CYP4F11 | AREL1 | 0.869 | bioplex3_WMM WMM_only | ||
| SLC4A11 | AREL1 | 0.869 | bioplex3_WMM WMM_only | ||
| PIGQ | CYP4F11 | 0.73 | 0.126 | bioplex3_WMM WMM_only | |
| PIGQ | SLC4A11 | 0.73 | 0.054 | bioplex3_WMM WMM_only | |
| KCNH2 | AREL1 | 0.73 | bioplex3_WMM WMM_only | ||
| PIGQ | AREL1 | 0.718 | bioplex3_WMM WMM_only | ||
| PIGQ | ENTREP3 | 0.692 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KCNH2 | PIGA | 0.675 | bioplex3_WMM WMM_only | ||
| PIGA | SLC4A11 | 0.675 | 0.102 | bioplex3_WMM WMM_only | |
| PIGP | PIGQ | 0.675 | bioplex3_WMM WMM_only | ||
| KCNH2 | PIGQ | 0.675 | bioplex3_WMM WMM_only | ||
| PIGA | CYP4F11 | 0.675 | 0.16 | bioplex3_WMM WMM_only | |
| PIGP | AREL1 | 0.675 | bioplex3_WMM WMM_only | ||
| ENTREP3 | SLC4A11 | 0.652 | bioplex3_WMM WMM_only | ||
| CYP4F11 | ENTREP3 | 0.652 | bioplex3_WMM WMM_only | ||
| PIGA | PIGQ | 0.639 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| KCNH2 | ENTREP3 | 0.552 | bioplex3_WMM WMM_only | ||
| PIGP | ENTREP3 | 0.545 | bioplex3_WMM WMM_only |
Related Complexes