hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07570.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDRF1 | Erythroid differentiation-related factor 1 | 5 | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | 5 | UniProt NCBI |
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) | 5 | UniProt NCBI |
| CDC37L1 | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | 5 | UniProt NCBI |
| HSP90AA1 | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | 5 | UniProt NCBI |
| UNC45B | Protein unc-45 homolog B (Unc-45B) (SMUNC45) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 5.12534978153e-05 | 0.333333333333 | HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 0.000170782642132 | 0.333333333333 | HSP90AB1 HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 0.00025612721106 | 0.333333333333 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| REAC:R-HSA-5336415 | 0.000387015749065 | 0.333333333333 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| CORUM:5268 | 0.000477929626316 | 0.333333333333 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5212 | 0.000477929626316 | 0.333333333333 | HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| CORUM:5286 | 0.000767820823501 | 0.333333333333 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5266 | 0.00133016076778 | 0.333333333333 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 6 |
| REAC:R-HSA-3371511 | 0.00170100530318 | 0.333333333333 | HSP90AB1 HSP90AA1 | HSF1 activation |
| REAC:R-HSA-3371568 | 0.00200991204249 | 0.333333333333 | HSP90AB1 HSP90AA1 | Attenuation phase |
| CORUM:5199 | 0.00204528068441 | 0.333333333333 | HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-399954 | 0.00270466310657 | 0.333333333333 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-5339562 | 0.00440152140132 | 0.333333333333 | HSP90AB1 HSP90AA1 | Uptake and actions of bacterial toxins |
| REAC:R-HSA-9613829 | 0.00540340354533 | 0.333333333333 | HSP90AB1 HSP90AA1 | Chaperone Mediated Autophagy |
| REAC:R-HSA-3371571 | 0.00650743774508 | 0.333333333333 | HSP90AB1 HSP90AA1 | HSF1-dependent transactivation |
| REAC:R-HSA-9013418 | 0.00650743774508 | 0.333333333333 | HSP90AB1 HSP90AA1 | RHOBTB2 GTPase cycle |
| GO:1902949 | 0.00702301080125 | 0.333333333333 | HSP90AB1 HSP90AA1 | positive regulation of tau-protein kinase activity |
| GO:0006457 | 0.0118285149586 | 0.666666666667 | HSP90AB1 UNC45B CDC37L1 HSP90AA1 | protein folding |
| KEGG:04612 | 0.0131618550544 | 0.333333333333 | HSP90AB1 HSP90AA1 | Antigen processing and presentation |
| REAC:R-HSA-9706574 | 0.0152705482636 | 0.333333333333 | HSP90AB1 HSP90AA1 | RHOBTB GTPase Cycle |
| KEGG:04657 | 0.0209831060756 | 0.333333333333 | HSP90AB1 HSP90AA1 | IL-17 signaling pathway |
| KEGG:04914 | 0.0237939838034 | 0.333333333333 | HSP90AB1 HSP90AA1 | Progesterone-mediated oocyte maturation |
| KEGG:05215 | 0.0286526780492 | 0.333333333333 | HSP90AB1 HSP90AA1 | Prostate cancer |
| KEGG:04659 | 0.0286526780492 | 0.333333333333 | HSP90AB1 HSP90AA1 | Th17 cell differentiation |
| KEGG:04915 | 0.0299366365218 | 0.333333333333 | HSP90AB1 HSP90AA1 | Estrogen signaling pathway |
| REAC:R-HSA-3371497 | 0.0339259639772 | 0.333333333333 | HSP90AB1 HSP90AA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-2029482 | 0.0393724000146 | 0.333333333333 | HSP90AB1 HSP90AA1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-9824439 | 0.0437202891307 | 0.333333333333 | HSP90AB1 HSP90AA1 | Bacterial Infection Pathways |
| REAC:R-HSA-373755 | 0.0437202891307 | 0.333333333333 | HSP90AB1 HSP90AA1 | Semaphorin interactions |
| KEGG:05418 | 0.0483092600715 | 0.333333333333 | HSP90AB1 HSP90AA1 | Fluid shear stress and atherosclerosis |
| CORUM:5716 | 0.0499436884912 | 0.166666666667 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSP90AB1 | HSP90AA1 | 1.0 | 0.954 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EDRF1 | HSP90AB1 | 0.995 | 0.32305 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| CDC37L1 | HSP90AB1 | 0.986 | 0.351110091582 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EDRF1 | HSP90AA1 | 0.983 | 0.474 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| TSSK6 | HSP90AA1 | 0.98 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSSK6 | HSP90AB1 | 0.978 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDC37L1 | HSP90AA1 | 0.966 | 0.479316479401 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| HSP90AB1 | UNC45B | 0.963 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSP90AA1 | UNC45B | 0.952 | 0.207431818182 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDC37L1 | EDRF1 | 0.667 | 0.082 | bioplex3_WMM WMM_only |
Related Complexes