hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07573.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL4A6 | Collagen alpha-6(IV) chain | 5 | UniProt NCBI |
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL14A1 | Collagen alpha-1(XIV) chain (Undulin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 2.59981278465e-08 | 1.0 | COL4A6 COL14A1 COL4A4 PLOD1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 9.87962469194e-08 | 1.0 | COL4A6 COL14A1 COL4A4 PLOD1 | Collagen formation |
| REAC:R-HSA-8948216 | 5.68914662089e-06 | 0.75 | COL4A6 COL14A1 COL4A4 | Collagen chain trimerization |
| REAC:R-HSA-1474244 | 1.05306246315e-05 | 1.0 | COL4A6 COL14A1 COL4A4 PLOD1 | Extracellular matrix organization |
| KEGG:04974 | 1.79251891439e-05 | 0.75 | COL4A6 COL14A1 COL4A4 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 2.27017011202e-05 | 0.75 | COL4A6 COL14A1 COL4A4 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 2.57917427086e-05 | 0.75 | COL4A6 COL14A1 COL4A4 | Collagen degradation |
| HP:0011501 | 0.000100319571443 | 0.5 | COL4A6 COL4A4 | Anterior lenticonus |
| REAC:R-HSA-1474228 | 0.000261669015753 | 0.75 | COL4A6 COL14A1 COL4A4 | Degradation of the extracellular matrix |
| GO:0005581 | 0.000680215375943 | 0.75 | COL4A6 COL14A1 COL4A4 | collagen trimer |
| HP:0001142 | 0.000701980712879 | 0.5 | COL4A6 COL4A4 | Lenticonus |
| REAC:R-HSA-2214320 | 0.000798898068561 | 0.5 | COL4A6 COL4A4 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 0.00122873738811 | 0.5 | COL4A6 COL4A4 | Crosslinking of collagen fibrils |
| GO:0030020 | 0.00140301566648 | 0.75 | COL4A6 COL14A1 COL4A4 | extracellular matrix structural constituent conferring tensile strength |
| HP:0011526 | 0.00260592941411 | 0.5 | COL4A6 COL4A4 | Abnormality of lens shape |
| REAC:R-HSA-3000157 | 0.00359044851421 | 0.5 | COL4A6 COL4A4 | Laminin interactions |
| KEGG:04512 | 0.00551283411821 | 0.5 | COL4A6 COL4A4 | ECM-receptor interaction |
| KEGG:05146 | 0.00909742323246 | 0.5 | COL4A6 COL4A4 | Amoebiasis |
| KEGG:05222 | 0.00909742323246 | 0.5 | COL4A6 COL4A4 | Small cell lung cancer |
| KEGG:04933 | 0.00931062778609 | 0.5 | COL4A6 COL4A4 | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP4658 | 0.00992155513194 | 0.5 | COL4A6 COL4A4 | Small cell lung cancer |
| HP:0100751 | 0.0108451581837 | 0.5 | COL4A6 COL14A1 | Esophageal neoplasm |
| REAC:R-HSA-3000171 | 0.0115164156767 | 0.5 | COL4A6 COL4A4 | Non-integrin membrane-ECM interactions |
| KEGG:04926 | 0.014352694406 | 0.5 | COL4A6 COL4A4 | Relaxin signaling pathway |
| REAC:R-HSA-3000178 | 0.0168610262513 | 0.5 | COL4A6 COL4A4 | ECM proteoglycans |
| HP:0012288 | 0.0176079483787 | 0.5 | COL4A6 COL14A1 | Neoplasm of head and neck |
| REAC:R-HSA-216083 | 0.0199119958937 | 0.5 | COL4A6 COL4A4 | Integrin cell surface interactions |
| WP:WP4239 | 0.0218193051527 | 0.5 | COL4A6 COL4A4 | Epithelial to mesenchymal transition in colorectal cancer |
| GO:0005587 | 0.0280843539964 | 0.5 | COL4A6 COL4A4 | collagen type IV trimer |
| KEGG:04510 | 0.03673756538 | 0.5 | COL4A6 COL4A4 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | COL4A6 COL4A4 | Focal adhesion |
| HP:0000545 | 0.0385249398527 | 0.75 | COL4A6 COL4A4 PLOD1 | Myopia |
| GO:0098651 | 0.042122686785 | 0.5 | COL4A6 COL4A4 | basement membrane collagen trimer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COL4A4 | PLOD1 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLOD1 | COL4A6 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLOD1 | COL14A1 | 0.951 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| COL4A6 | COL14A1 | 0.36 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL4A4 | COL14A1 | 0.107 | bioplex3_WMM WMM_only | |
| COL4A4 | COL4A6 | 0.106 | bioplex3_WMM WMM_only |
Related Complexes