hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07585.1

Complex Portal: CPX-12468

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
KAT2B	Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)	5	UniProt NCBI
TADA3	Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein)	5	UniProt NCBI
NCOA6	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	5	UniProt NCBI
KAT2A	Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)	5	UniProt NCBI
KMT2D	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	5	UniProt NCBI
SGF29	SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29)	5	UniProt NCBI
ATN1	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	5	UniProt NCBI
RERE	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	5	UniProt NCBI
WDR5	WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9772755	5.61388081545e-15	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	Formation of WDR5-containing histone-modifying complexes
REAC:R-HSA-212165	2.2202286521e-10	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	Epigenetic regulation of gene expression
CORUM:6657	1.12839162173e-09	0.444444444444	KAT2A WDR5 TADA3 SGF29	ATAC complex, GCN5-linked
GO:0140672	1.45750652247e-09	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	ATAC complex
CORUM:6665	5.37277714268e-09	0.444444444444	KAT2A WDR5 TADA3 SGF29	ATAC complex, YEATS2-linked
GO:0090043	7.00141271396e-09	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	regulation of tubulin deacetylation
GO:0090042	1.75299888387e-08	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	tubulin deacetylation
GO:0090311	2.97616055168e-08	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	regulation of protein deacetylation
GO:0006476	3.65797757329e-07	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	protein deacetylation
GO:0070461	4.24700324456e-07	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	SAGA-type complex
REAC:R-HSA-4839726	4.5001456838e-07	0.666666666667	WDR5 KAT2B SGF29 KMT2D KAT2A TADA3	Chromatin organization
REAC:R-HSA-3247509	4.5001456838e-07	0.666666666667	WDR5 KAT2B SGF29 KMT2D KAT2A TADA3	Chromatin modifying enzymes
GO:0035601	9.57006592588e-07	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	protein deacylation
GO:0098732	9.57006592588e-07	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	macromolecule deacylation
CORUM:6467	1.0989783268e-06	0.333333333333	KMT2D NCOA6 WDR5	MLL4 complex
REAC:R-HSA-3214847	1.43852528668e-06	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	HATs acetylate histones
CORUM:3075	2.87561751823e-06	0.333333333333	KMT2D NCOA6 WDR5	UTX-MLL2/3 complex
GO:0045995	5.13607866526e-06	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	regulation of embryonic development
CORUM:6643	1.26384976661e-05	0.333333333333	KAT2A TADA3 SGF29	SAGA complex, GCN5-linked
CORUM:6664	1.26384976661e-05	0.333333333333	KAT2A TADA3 SGF29	STAGA complex, SPT3-linked
GO:0000124	1.97504384826e-05	0.444444444444	KAT2A SGF29 KAT2B TADA3	SAGA complex
GO:0003712	2.51002472958e-05	0.777777777778	KAT2B ATN1 NCOA6 KMT2D KAT2A TADA3 RERE	transcription coregulator activity
GO:0000123	4.36113477299e-05	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	histone acetyltransferase complex
GO:1902493	7.54268389953e-05	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	acetyltransferase complex
GO:0031248	7.54268389953e-05	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	protein acetyltransferase complex
GO:0051302	0.000129431186759	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	regulation of cell division
CORUM:1399	0.000164069436391	0.222222222222	KMT2D WDR5	WDR5-ASH2L-RBBP5-MLL2 complex
REAC:R-HSA-74160	0.000310280743802	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	Gene expression (Transcription)
CORUM:1400	0.000573693030134	0.222222222222	KMT2D NCOA6	ASCOM complex
CORUM:6641	0.000764679747525	0.222222222222	KAT2A TADA3	USP22-SAGA complex
GO:0072686	0.000870425537234	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	mitotic spindle
CORUM:6461	0.000982845681582	0.222222222222	WDR5 NCOA6	MLL3 complex
CORUM:438	0.00122816473062	0.222222222222	KAT2A TADA3	GCN5-TRRAP histone acetyltransferase complex
CORUM:477	0.00122816473062	0.222222222222	KAT2B TADA3	PCAF complex
CORUM:1401	0.00122816473062	0.222222222222	KMT2D WDR5	MOF complex
CORUM:471	0.00122816473062	0.222222222222	KAT2B TADA3	PCAF complex
CORUM:5195	0.00122816473062	0.222222222222	WDR5 NCOA6	PTIP-HMT complex
CORUM:6460	0.00122816473062	0.222222222222	KMT2D WDR5	MLL2 complex
GO:0044666	0.00132894467527	0.333333333333	KMT2D NCOA6 WDR5	MLL3/4 complex
GO:0030674	0.00164396280271	0.777777777778	KAT2B ATN1 NCOA6 KMT2D KAT2A TADA3 RERE	protein-macromolecule adaptor activity
CORUM:475	0.00180015784734	0.222222222222	KAT2A TADA3	STAGA complex
GO:1990234	0.00191638157877	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	transferase complex
CORUM:476	0.00212677979211	0.222222222222	KAT2A TADA3	STAGA complex
REAC:R-HSA-8936459	0.00307013622401	0.333333333333	KMT2D KAT2B WDR5	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
CORUM:462	0.00326883477195	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
CORUM:456	0.00326883477195	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
CORUM:455	0.00326883477195	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
CORUM:445	0.00326883477195	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
CORUM:470	0.00370349612966	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
CORUM:513	0.00370349612966	0.222222222222	KAT2A TADA3	TFTC complex (TATA-binding protein-free TAF-II-containing complex)
REAC:R-HSA-210744	0.00438093013445	0.222222222222	KAT2A KAT2B	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REAC:R-HSA-8941856	0.00438093013445	0.222222222222	KAT2A KAT2B	RUNX3 regulates NOTCH signaling
GO:0060090	0.00486640736746	0.777777777778	KAT2B ATN1 NCOA6 KMT2D KAT2A TADA3 RERE	molecular adaptor activity
GO:0003713	0.00615819988753	0.555555555556	NCOA6 KAT2A KMT2D KAT2B TADA3	transcription coactivator activity
GO:0051301	0.00629004142941	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	cell division
REAC:R-HSA-5617472	0.00715131398855	0.333333333333	KMT2D NCOA6 WDR5	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	0.00715131398855	0.333333333333	KMT2D NCOA6 WDR5	Activation of HOX genes during differentiation
REAC:R-HSA-9013695	0.00835291407054	0.222222222222	KAT2A KAT2B	NOTCH4 Intracellular Domain Regulates Transcription
REAC:R-HSA-9793380	0.0121597301349	0.222222222222	KAT2A KAT2B	Formation of paraxial mesoderm
WP:WP5351	0.012380386891	0.222222222222	WDR5 NCOA6	Kleefstra syndrome
GO:1905368	0.0126624076937	0.444444444444	KAT2A SGF29 KAT2B TADA3	peptidase complex
GO:0006357	0.0145554752998	0.888888888889	WDR5 KAT2B ATN1 NCOA6 KMT2D KAT2A TADA3 SGF29	regulation of transcription by RNA polymerase II
REAC:R-HSA-9013508	0.0150906736209	0.222222222222	KAT2A KAT2B	NOTCH3 Intracellular Domain Regulates Transcription
GO:0045893	0.0154442953573	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	positive regulation of DNA-templated transcription
GO:1902680	0.0157504090511	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	positive regulation of RNA biosynthetic process
REAC:R-HSA-1266738	0.0165011170168	0.555555555556	KAT2A KMT2D WDR5 KAT2B NCOA6	Developmental Biology
REAC:R-HSA-350054	0.0183353632609	0.222222222222	KAT2A KAT2B	Notch-HLH transcription pathway
KEGG:04330	0.0189437044705	0.222222222222	KAT2A KAT2B	Notch signaling pathway
WP:WP268	0.0191680266266	0.222222222222	KAT2A KAT2B	Notch signaling
GO:0000122	0.0206219094099	0.666666666667	WDR5 KAT2B ATN1 SGF29 KAT2A TADA3	negative regulation of transcription by RNA polymerase II
GO:0005819	0.0214567837679	0.555555555556	KAT2A SGF29 WDR5 KAT2B TADA3	spindle
GO:0006366	0.0221609176661	0.888888888889	WDR5 KAT2B ATN1 NCOA6 KMT2D KAT2A TADA3 SGF29	transcription by RNA polymerase II
REAC:R-HSA-186712	0.0237893486791	0.222222222222	KAT2A KAT2B	Regulation of beta-cell development
KEGG:03250	0.0267263448961	0.222222222222	KAT2A KAT2B	Viral life cycle - HIV-1
HP:0001655	0.0298269199151	0.333333333333	KMT2D RERE ATN1	Patent foramen ovale
GO:0051254	0.0338404915513	0.777777777778	WDR5 KAT2B NCOA6 KMT2D KAT2A TADA3 SGF29	positive regulation of RNA metabolic process
GO:0045815	0.0396911574974	0.333333333333	WDR5 KAT2B SGF29	transcription initiation-coupled chromatin remodeling
GO:0141137	0.0436468140298	0.333333333333	WDR5 KAT2B SGF29	positive regulation of gene expression, epigenetic

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TADA3	SGF29	1.0	0.484		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM
TADA3	KAT2A	1.0	0.286		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM
KAT2A	SGF29	0.999	0.32		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM
KAT2B	TADA3	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KAT2B	SGF29	0.997		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
WDR5	KAT2A	0.995	0.326	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ATN1	WDR5	0.994	0.142	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
WDR5	KAT2B	0.992		mutually_exclusive (Q96ES7) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RERE	WDR5	0.986	0.19		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM
WDR5	SGF29	0.985	0.464	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
NCOA6	WDR5	0.984	0.352		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
WDR5	TADA3	0.984	0.202	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
WDR5	KMT2D	0.982	0.0641691542289		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () gupta_WMM boldt_WMM
RERE	KMT2D	0.966	0.184		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
KAT2B	KAT2A	0.944			bioplex_WMM bioplex3_WMM WMM_only
ATN1	RERE	0.929	0.28		bioplex_WMM bioplex3_WMM WMM_only
NCOA6	KMT2D	0.759	0.118		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOA6	ATN1	0.417	0.296		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ATN1	KMT2D	0.4	0.152		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOA6	RERE	0.357	0.178		bioplex_WMM bioplex3_WMM WMM_only
NCOA6	KAT2B	0.273			bioplex_WMM bioplex3_WMM WMM_only
TADA3	KMT2D	0.256	0.128		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOA6	KAT2A	0.25	0.226		bioplex_WMM bioplex3_WMM WMM_only
RERE	KAT2B	0.242			bioplex_WMM bioplex3_WMM WMM_only
NCOA6	TADA3	0.227	0.404		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ATN1	KAT2A	0.223	0.248		bioplex_WMM bioplex3_WMM WMM_only
KAT2A	KMT2D	0.223	0.222		bioplex_WMM bioplex3_WMM WMM_only
ATN1	TADA3	0.223	0.19	mutually_exclusive (P61964)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RERE	TADA3	0.22	0.24		bioplex_WMM bioplex3_WMM WMM_only
RERE	KAT2A	0.22	0.182		bioplex_WMM bioplex3_WMM WMM_only
ATN1	KAT2B	0.215			bioplex_WMM bioplex3_WMM WMM_only
KAT2B	KMT2D	0.215			bioplex_WMM bioplex3_WMM WMM_only
ATN1	SGF29	0.164	0.236	mutually_exclusive (P61964)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RERE	SGF29	0.109	0.116		bioplex_WMM bioplex3_WMM WMM_only
SGF29	KMT2D	0.042	0.066		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
NCOA6	SGF29	0.032	0.458		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
KAT2B	huMAP3_00372.1 huMAP3_00902.1 huMAP3_03789.1 huMAP3_07585.1 huMAP3_08451.1 huMAP3_08776.1 huMAP3_09422.1 huMAP3_09561.1 huMAP3_10027.1 huMAP3_10385.1 huMAP3_10397.1 huMAP3_12550.1
TADA3	huMAP3_00372.1 huMAP3_00902.1 huMAP3_02107.1 huMAP3_07585.1 huMAP3_08451.1 huMAP3_08776.1 huMAP3_09422.1 huMAP3_09561.1 huMAP3_10027.1 huMAP3_10385.1 huMAP3_10397.1 huMAP3_12550.1
NCOA6	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KAT2A	huMAP3_00372.1 huMAP3_00902.1 huMAP3_03789.1 huMAP3_07585.1 huMAP3_08451.1 huMAP3_08776.1 huMAP3_09422.1 huMAP3_09561.1 huMAP3_10027.1 huMAP3_10385.1 huMAP3_10397.1 huMAP3_12550.1
KMT2D	huMAP3_07585.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
SGF29	huMAP3_00902.1 huMAP3_03789.1 huMAP3_07585.1 huMAP3_08451.1 huMAP3_09561.1 huMAP3_10385.1 huMAP3_10397.1 huMAP3_11469.1 huMAP3_12550.1
ATN1	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
RERE	huMAP3_00047.1 huMAP3_01287.1 huMAP3_07585.1 huMAP3_08605.1 huMAP3_08776.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09422.1 huMAP3_09513.1 huMAP3_10027.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
WDR5	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07585.1

Complex Portal: CPX-12468