hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07588.1
Complex Portal: CPX-21479
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BRAF | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | 5 | UniProt NCBI |
| KRAS | GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] | 5 | UniProt NCBI |
| ARAF | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | 5 | UniProt NCBI |
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | 5 | UniProt NCBI |
| KSR1 | Kinase suppressor of Ras 1 (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4928 | 0.000103023242897 | 0.666666666667 | KRAS KSR1 | MAPK pathway in congenital thyroid cancer |
| KEGG:04625 | 0.00271491421694 | 0.666666666667 | KRAS KSR1 | C-type lectin receptor signaling pathway |
| WP:WP231 | 0.0039339723602 | 0.666666666667 | KRAS KSR1 | TNF alpha signaling pathway |
| REAC:R-HSA-6802955 | 0.00478550282195 | 0.666666666667 | KRAS KSR1 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.00478550282195 | 0.666666666667 | KRAS KSR1 | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 0.00478550282195 | 0.666666666667 | KRAS KSR1 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 0.00478550282195 | 0.666666666667 | KRAS KSR1 | Signaling downstream of RAS mutants |
| WP:WP4223 | 0.0120750625641 | 0.666666666667 | KRAS KSR1 | Ras signaling |
| KEGG:04014 | 0.0127453972967 | 0.666666666667 | KRAS KSR1 | Ras signaling pathway |
| REAC:R-HSA-6802957 | 0.0168905285744 | 0.666666666667 | KRAS KSR1 | Oncogenic MAPK signaling |
| CORUM:5918 | 0.0249718442456 | 0.333333333333 | KSR1 | KSR1 homo-oligomer complex |
| CORUM:5921 | 0.0499402709677 | 0.333333333333 | KSR1 | KSR1-BRAF-MEK complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BRAF | ARAF | 0.989 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| RAB3GAP1 | BRAF | 0.987 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KSR1 | BRAF | 0.985 | 0.11 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| KRAS | BRAF | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KSR1 | ARAF | 0.959 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RAB3GAP1 | KRAS | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KRAS | ARAF | 0.087 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAB3GAP1 | ARAF | 0.019 | 0.128333333333 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes