hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07604.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP6NL | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | 5 | UniProt NCBI |
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | 5 | UniProt NCBI |
| RC3H1 | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | 5 | UniProt NCBI |
| TMEM51 | Transmembrane protein 51 | 5 | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | 5 | UniProt NCBI |
| WWP2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1769 | 5.12534978153e-05 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| CORUM:1767 | 0.000102488289015 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 0.000170782642132 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1141 | 0.00133016076778 | 0.333333333333 | NUDT21 CPSF6 | CF IIAm complex (Cleavage factor IIAm complex) |
| GO:1990120 | 0.0210651876021 | 0.333333333333 | NUDT21 CPSF6 | messenger ribonucleoprotein complex assembly |
| KEGG:03015 | 0.029291198851 | 0.333333333333 | NUDT21 CPSF6 | mRNA surveillance pathway |
| GO:0110104 | 0.042122686785 | 0.333333333333 | NUDT21 CPSF6 | mRNA alternative polyadenylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.892 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | WWP2 | 0.992 | 0.591481481481 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| TMEM51 | WWP2 | 0.99 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CPSF6 | WWP2 | 0.986 | 0.696 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM |
| USP6NL | WWP2 | 0.956 | 0.136 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| RC3H1 | WWP2 | 0.955 | 0.18 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
| RC3H1 | TMEM51 | 0.415 | 0.142 | bioplex3_WMM WMM_only |
| USP6NL | TMEM51 | 0.213 | 0.088 | bioplex3_WMM gupta_WMM WMM_only |
| USP6NL | RC3H1 | 0.079 | 0.158 | bioplex3_WMM WMM_only |
| NUDT21 | TMEM51 | 0.077 | 0.104 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CPSF6 | TMEM51 | 0.023 | 0.144 | bioplex3_WMM gupta_WMM WMM_only |
| CPSF6 | USP6NL | 0.022 | 0.11 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CPSF6 | RC3H1 | 0.017 | 0.392 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUDT21 | USP6NL | 0.007 | 0.104 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUDT21 | RC3H1 | 0.005 | 0.594 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes