hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07613.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DICER1 | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | 5 | UniProt NCBI |
| TARBP2 | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | 5 | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5381 | 2.33868713081e-10 | 1.0 | DICER1 TARBP2 AGO2 | RNA-induced silencing complex, RISC |
| CORUM:5377 | 2.33868713081e-10 | 1.0 | DICER1 TARBP2 AGO2 | RNA-induced silencing complex, RISC |
| CORUM:3032 | 9.35474852325e-10 | 1.0 | DICER1 TARBP2 AGO2 | RNA-induced silencing complex, RISC |
| CORUM:5378 | 4.67737426163e-09 | 1.0 | DICER1 TARBP2 AGO2 | TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) |
| REAC:R-HSA-426486 | 3.91945798564e-08 | 1.0 | DICER1 TARBP2 AGO2 | Small interfering RNA (siRNA) biogenesis |
| WP:WP4844 | 3.14715618363e-07 | 1.0 | DICER1 TARBP2 AGO2 | Influence of laminopathies on Wnt signaling |
| REAC:R-HSA-203927 | 8.26352391973e-07 | 1.0 | DICER1 TARBP2 AGO2 | MicroRNA (miRNA) biogenesis |
| WP:WP4879 | 1.2569245694e-06 | 1.0 | DICER1 TARBP2 AGO2 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:0030422 | 5.38272230028e-06 | 1.0 | DICER1 TARBP2 AGO2 | siRNA processing |
| GO:0035197 | 5.38272230028e-06 | 1.0 | DICER1 TARBP2 AGO2 | siRNA binding |
| GO:0070578 | 5.38272230028e-06 | 1.0 | DICER1 TARBP2 AGO2 | RISC-loading complex |
| CORUM:1385 | 1.02521027753e-05 | 0.666666666667 | DICER1 AGO2 | DICER1-NCOA6-AGO2 complex |
| GO:0070922 | 1.15344049292e-05 | 1.0 | DICER1 TARBP2 AGO2 | RISC complex assembly |
| WP:WP4549 | 1.6729538117e-05 | 1.0 | DICER1 TARBP2 AGO2 | Fragile X syndrome |
| WP:WP2805 | 1.69880545178e-05 | 0.666666666667 | DICER1 AGO2 | exRNA mechanism of action and biogenesis |
| WP:WP2338 | 1.69880545178e-05 | 0.666666666667 | DICER1 TARBP2 | miRNA biogenesis |
| GO:0031332 | 3.49876949518e-05 | 1.0 | DICER1 TARBP2 AGO2 | RNAi effector complex |
| GO:0016442 | 3.49876949518e-05 | 1.0 | DICER1 TARBP2 AGO2 | RISC complex |
| GO:0031054 | 5.38272230028e-05 | 1.0 | DICER1 TARBP2 AGO2 | pre-miRNA processing |
| REAC:R-HSA-211000 | 0.000124543577107 | 1.0 | DICER1 TARBP2 AGO2 | Gene Silencing by RNA |
| GO:1902555 | 0.000432059584639 | 1.0 | DICER1 TARBP2 AGO2 | endoribonuclease complex |
| GO:1905348 | 0.000629105668845 | 1.0 | DICER1 TARBP2 AGO2 | endonuclease complex |
| GO:0035196 | 0.000810868666521 | 1.0 | DICER1 TARBP2 AGO2 | miRNA processing |
| GO:0061980 | 0.000878441055398 | 1.0 | DICER1 TARBP2 AGO2 | regulatory RNA binding |
| GO:0070918 | 0.00252170927764 | 1.0 | DICER1 TARBP2 AGO2 | regulatory ncRNA processing |
| GO:0003725 | 0.00266444753864 | 1.0 | DICER1 TARBP2 AGO2 | double-stranded RNA binding |
| GO:0016441 | 0.00328922780564 | 1.0 | DICER1 TARBP2 AGO2 | post-transcriptional gene silencing |
| GO:0098795 | 0.00421361424067 | 0.666666666667 | DICER1 TARBP2 | global gene silencing by mRNA cleavage |
| GO:0031047 | 0.0128843147861 | 1.0 | DICER1 TARBP2 AGO2 | regulatory ncRNA-mediated gene silencing |
| WP:WP2943 | 0.0165527833611 | 0.333333333333 | DICER1 | Hypoxia mediated EMT and stemness |
| CORUM:1387 | 0.0249718442456 | 0.333333333333 | AGO2 | TTP-AGO2 complex |
| CORUM:5360 | 0.0499402709677 | 0.333333333333 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DICER1 | TARBP2 | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM treiber_WMM | |
| DICER1 | AGO2 | 0.97 | 0.118979591837 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| TARBP2 | AGO2 | 0.965 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
Related Complexes