hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07622.1
Complex Portal: CPX-11982
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCDN | Neurochondrin | 5 | UniProt NCBI |
| ECD | Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) | 5 | UniProt NCBI |
| TSSC4 | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | 5 | UniProt NCBI |
| EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | 5 | UniProt NCBI |
| PRPF8 | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | 5 | UniProt NCBI |
| SNRNP40 | U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) | 5 | UniProt NCBI |
| EAPP | E2F-associated phosphoprotein (EAPP) | 5 | UniProt NCBI |
| AAR2 | Protein AAR2 homolog (AAR2 splicing factor homolog) | 3 | UniProt NCBI |
| SNRNP200 | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005682 | 9.69205058567e-09 | 0.555555555556 | SNRNP200 AAR2 SNRNP40 TSSC4 PRPF8 | U5 snRNP |
| GO:0097525 | 2.30518753512e-08 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | spliceosomal snRNP complex |
| GO:0030532 | 5.22564912917e-08 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 1.33972143912e-07 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | Sm-like protein family complex |
| REAC:R-HSA-72165 | 3.0207398275e-06 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | mRNA Splicing - Minor Pathway |
| CORUM:1335 | 5.94180498143e-06 | 0.333333333333 | EFTUD2 PRPF8 SNRNP200 | SNW1 complex |
| CORUM:1181 | 7.13913096923e-06 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | C complex spliceosome |
| KEGG:03040 | 3.14265099225e-05 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | Spliceosome |
| CORUM:351 | 7.28748929384e-05 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | Spliceosome |
| GO:0000398 | 0.000137882167253 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.000137882167253 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.000150819802301 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | RNA splicing, via transesterification reactions |
| GO:0097526 | 0.000152495982273 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | spliceosomal tri-snRNP complex |
| GO:0046540 | 0.000152495982273 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | U4/U6 x U5 tri-snRNP complex |
| GO:0006397 | 0.00054983325342 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | mRNA processing |
| GO:0008380 | 0.000933461830496 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | RNA splicing |
| REAC:R-HSA-72163 | 0.000982323937459 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00112544726016 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | mRNA Splicing |
| GO:0000244 | 0.00292902387419 | 0.333333333333 | AAR2 TSSC4 PRPF8 | spliceosomal tri-snRNP complex assembly |
| REAC:R-HSA-72203 | 0.0033511074443 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | Processing of Capped Intron-Containing Pre-mRNA |
| WP:WP411 | 0.00419312016767 | 0.333333333333 | EFTUD2 PRPF8 SNRNP40 | mRNA processing |
| GO:0071013 | 0.00721358821272 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | catalytic step 2 spliceosome |
| GO:0005684 | 0.00790837187115 | 0.444444444444 | SNRNP200 EFTUD2 PRPF8 SNRNP40 | U2-type spliceosomal complex |
| GO:0016071 | 0.0110055348832 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | mRNA metabolic process |
| GO:1990904 | 0.0163020400735 | 0.666666666667 | EFTUD2 SNRNP200 AAR2 PRPF8 TSSC4 SNRNP40 | ribonucleoprotein complex |
| GO:0071007 | 0.0325091721374 | 0.333333333333 | EFTUD2 PRPF8 SNRNP40 | U2-type catalytic step 2 spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EFTUD2 | PRPF8 | 1.0 | 0.996 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EFTUD2 | SNRNP200 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EFTUD2 | TSSC4 | 1.0 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| EFTUD2 | AAR2 | 1.0 | 0.679 |
structurally_consistent (Q96DI7)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PRPF8 | SNRNP200 | 1.0 | 0.994 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| EAPP | AAR2 | 1.0 | 0.11 |
structurally_consistent (Q6P2Q9)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| ECD | EAPP | 1.0 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SNRNP40 | TSSC4 | 0.999 | 0.264 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM | |
| EFTUD2 | EAPP | 0.999 | 0.212 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM | |
| ECD | TSSC4 | 0.999 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| EAPP | TSSC4 | 0.999 | 0.176 |
structurally_consistent (Q6P2Q9)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| EFTUD2 | SNRNP40 | 0.999 | 0.788 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| ECD | AAR2 | 0.999 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SNRNP200 | TSSC4 | 0.999 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| AAR2 | SNRNP200 | 0.999 | 0.556 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| ECD | EFTUD2 | 0.999 | 0.273674178404 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SNRNP40 | SNRNP200 | 0.999 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| SNRNP40 | PRPF8 | 0.999 | 0.968 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| NCDN | ECD | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EAPP | SNRNP200 | 0.999 | 0.282 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| NCDN | AAR2 | 0.999 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| AAR2 | PRPF8 | 0.998 | 0.5855 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AAR2 | TSSC4 | 0.998 | 0.246 |
structurally_consistent (Q6P2Q9)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM |
| PRPF8 | TSSC4 | 0.998 | 0.218 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction boldt_WMM |
| NCDN | SNRNP40 | 0.998 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NCDN | EAPP | 0.996 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| EAPP | PRPF8 | 0.994 | 0.268 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction boldt_WMM |
| SNRNP40 | AAR2 | 0.994 | 0.354 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM |
| NCDN | TSSC4 | 0.991 | 0.124 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ECD | SNRNP200 | 0.988 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SNRNP40 | EAPP | 0.987 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM | |
| ECD | PRPF8 | 0.985 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ECD | SNRNP40 | 0.985 | 0.012 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NCDN | EFTUD2 | 0.976 | 0.202 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| NCDN | PRPF8 | 0.444 | 0.07 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| NCDN | SNRNP200 | 0.317 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes