hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07624.1
Complex Portal: CPX-19971
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CYP2C18 | Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) | 5 | UniProt NCBI |
| CYP2C8 | Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C19 | Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2491 | 2.55382210955e-06 | 1.0 | CYP2C19 CYP2C18 | Diclofenac metabolic pathway |
| KEGG:05204 | 0.000224021038984 | 1.0 | CYP2C19 CYP2C18 | Chemical carcinogenesis - DNA adducts |
| REAC:R-HSA-211981 | 0.000358839967947 | 1.0 | CYP2C19 CYP2C18 | Xenobiotics |
| WP:WP43 | 0.00036647347272 | 1.0 | CYP2C19 CYP2C18 | Oxidation by cytochrome P450 |
| KEGG:04726 | 0.000566717954934 | 1.0 | CYP2C19 CYP2C18 | Serotonergic synapse |
| REAC:R-HSA-211897 | 0.00169167413461 | 1.0 | CYP2C19 CYP2C18 | Cytochrome P450 - arranged by substrate type |
| WP:WP702 | 0.00384988683014 | 1.0 | CYP2C19 CYP2C18 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-211945 | 0.00499983688673 | 1.0 | CYP2C19 CYP2C18 | Phase I - Functionalization of compounds |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | CYP2C19 CYP2C18 | Biological oxidations |
| GO:0008392 | 0.0309012475255 | 1.0 | CYP2C19 CYP2C18 | arachidonic acid epoxygenase activity |
| GO:0008391 | 0.0365196561665 | 1.0 | CYP2C19 CYP2C18 | arachidonic acid monooxygenase activity |
| WP:WP4720 | 0.0373151717536 | 0.5 | CYP2C18 | Eicosanoid metabolism via cytochrome P450 monooxygenases pathway |
| GO:0019373 | 0.0426062655276 | 1.0 | CYP2C19 CYP2C18 | epoxygenase P450 pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CYP2C8 | CYP2C18 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CYP2C19 | CYP2C18 | 0.985 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes