hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07642.1
Complex Portal: CPX-17877
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | 5 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | 5 | UniProt NCBI |
| DOCK2 | Dedicator of cytokinesis protein 2 | 5 | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | 3 | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | 5 | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5341 | 1.36501667663e-05 | 0.4 | ELMO1 DOCK2 | ELMO1-DOCK2 complex |
| KEGG:05100 | 6.51136022216e-05 | 0.6 | ELMO1 ELMO2 ELMO3 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-9013408 | 0.000148520473584 | 0.6 | ELMO2 DOCK2 DOCK4 | RHOG GTPase cycle |
| REAC:R-HSA-164944 | 0.000319009353903 | 0.4 | ELMO1 DOCK2 | Nef and signal transduction |
| REAC:R-HSA-8849471 | 0.0011839189519 | 0.4 | ELMO1 ELMO2 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| REAC:R-HSA-164952 | 0.00531742996423 | 0.4 | ELMO1 DOCK2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-9006927 | 0.0156388304105 | 0.4 | ELMO1 ELMO2 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.0156388304105 | 0.4 | ELMO1 ELMO2 | Signaling by PTK6 |
| REAC:R-HSA-9664407 | 0.0208015819243 | 0.4 | ELMO1 ELMO2 | Parasite infection |
| REAC:R-HSA-9664422 | 0.0208015819243 | 0.4 | ELMO1 ELMO2 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 0.0208015819243 | 0.4 | ELMO1 ELMO2 | Leishmania phagocytosis |
| REAC:R-HSA-2029482 | 0.0232374901507 | 0.4 | ELMO1 ELMO2 | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:05135 | 0.0293384756517 | 0.4 | ELMO1 ELMO2 | Yersinia infection |
| REAC:R-HSA-9012999 | 0.0303172193635 | 0.6 | ELMO2 DOCK2 DOCK4 | RHO GTPase cycle |
| WP:WP3929 | 0.0420114386662 | 0.4 | ELMO1 DOCK2 | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | ELMO1 DOCK2 | Chemokine signaling pathway |
| REAC:R-HSA-2029480 | 0.0451765626421 | 0.4 | ELMO1 ELMO2 | Fcgamma receptor (FCGR) dependent phagocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ELMO1 | ELMO2 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO1 | DOCK4 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DOCK4 | ELMO2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| DOCK2 | ELMO3 | 0.993 | 0.112 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ELMO3 | ELMO2 | 0.991 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO1 | ELMO3 | 0.982 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAC2 | ELMO3 | 0.966 | 0.180711111111 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAC2 | ELMO2 | 0.952 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAC2 | DOCK4 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAC2 | ELMO1 | 0.916 | 0.24 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK2 | DOCK4 | 0.869 |
mutually_exclusive (Q92556)
|
bioplex3_WMM WMM_only | |
| DOCK2 | ELMO2 | 0.768 | 0.062 | bioplex3_WMM WMM_only | |
| RAC2 | DOCK2 | 0.133 | 0.262 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ELMO1 | DOCK2 | 0.055 | 0.328 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes