hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07645.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AHCTF1 | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | 5 | UniProt NCBI |
| SENP2 | Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) | 5 | UniProt NCBI |
| NUP210 | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | 5 | UniProt NCBI |
| SMPD4 | Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) | 5 | UniProt NCBI |
| NDC1 | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | 5 | UniProt NCBI |
| NUP155 | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | 5 | UniProt NCBI |
| SENP1 | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 1.54636599111e-08 | 0.714285714286 | NUP155 AHCTF1 NDC1 NUP210 SENP2 | Nucleocytoplasmic transport |
| GO:0005635 | 2.17273564069e-07 | 1.0 | NUP210 SENP1 NUP155 SMPD4 AHCTF1 SENP2 NDC1 | nuclear envelope |
| REAC:R-HSA-2990846 | 6.48717761862e-07 | 0.714285714286 | NUP155 SENP2 NDC1 SENP1 NUP210 | SUMOylation |
| WP:WP3998 | 3.02622905587e-06 | 0.571428571429 | NUP155 AHCTF1 NDC1 NUP210 | Prader Willi and Angelman syndrome |
| GO:0005643 | 5.44143672042e-06 | 0.714285714286 | NUP155 AHCTF1 NDC1 NUP210 SENP2 | nuclear pore |
| REAC:R-HSA-9615933 | 2.62784267685e-05 | 0.428571428571 | AHCTF1 NUP155 NDC1 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-5619107 | 4.24987071653e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 4.24987071653e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 4.73926619295e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168271 | 4.73926619295e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 4.73926619295e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-180910 | 5.82765337859e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 5.82765337859e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 5.82765337859e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 6.42919230078e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 6.42919230078e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 6.42919230078e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 7.07065782066e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 7.75332089956e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 7.75332089956e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 8.47845144152e-05 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.000100611892471 | 0.428571428571 | NUP210 NUP155 NDC1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.000109213310364 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.000118290093408 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.000127854887848 | 0.428571428571 | NUP210 NUP155 NDC1 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.00014849904315 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.000159603643781 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of RNA binding proteins |
| GO:0031967 | 0.000194627304791 | 1.0 | NUP210 SENP1 NUP155 SMPD4 AHCTF1 SENP2 NDC1 | organelle envelope |
| GO:0031975 | 0.000194627304791 | 1.0 | NUP210 SENP1 NUP155 SMPD4 AHCTF1 SENP2 NDC1 | envelope |
| REAC:R-HSA-2980766 | 0.000209532838622 | 0.428571428571 | NUP210 NUP155 NDC1 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.000268882655555 | 0.428571428571 | NUP210 NUP155 NDC1 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.000268882655555 | 0.428571428571 | NUP210 NUP155 NDC1 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.0003384553812 | 0.428571428571 | NUP210 NUP155 NDC1 | tRNA processing in the nucleus |
| GO:0031965 | 0.000517942930213 | 0.714285714286 | AHCTF1 NUP155 SMPD4 SENP1 NDC1 | nuclear membrane |
| REAC:R-HSA-70171 | 0.000562353197014 | 0.428571428571 | NUP210 NUP155 NDC1 | Glycolysis |
| REAC:R-HSA-3371453 | 0.000562353197014 | 0.428571428571 | NUP210 NUP155 NDC1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-3065679 | 0.000571118993049 | 0.285714285714 | SENP2 SENP1 | SUMO is proteolytically processed |
| REAC:R-HSA-4551638 | 0.000589010657253 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 0.000589010657253 | 0.428571428571 | NUP210 NUP155 NDC1 | ISG15 antiviral mechanism |
| REAC:R-HSA-2995410 | 0.000616493605077 | 0.428571428571 | AHCTF1 NUP155 NDC1 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-159236 | 0.000704018847769 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-5619102 | 0.000704018847769 | 0.428571428571 | NUP210 NUP155 NDC1 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.000734927167534 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.000766722633593 | 0.428571428571 | NUP210 NUP155 NDC1 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.00101516292409 | 0.428571428571 | NUP210 NUP155 NDC1 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-70326 | 0.00101516292409 | 0.428571428571 | NUP210 NUP155 NDC1 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.00126637654584 | 0.428571428571 | NUP210 NUP155 NDC1 | Cellular response to heat stress |
| REAC:R-HSA-3215018 | 0.00136974769985 | 0.285714285714 | SENP2 SENP1 | Processing and activation of SUMO |
| REAC:R-HSA-5578749 | 0.00155569177621 | 0.428571428571 | NUP210 NUP155 NDC1 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 0.00200524097522 | 0.428571428571 | NUP210 NUP155 NDC1 | tRNA processing |
| REAC:R-HSA-9610379 | 0.00200524097522 | 0.428571428571 | NUP210 NUP155 NDC1 | HCMV Late Events |
| REAC:R-HSA-9705671 | 0.00290605023767 | 0.428571428571 | NUP210 NUP155 NDC1 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-68886 | 0.00308249436511 | 0.571428571429 | NUP155 AHCTF1 NDC1 NUP210 | M Phase |
| REAC:R-HSA-211000 | 0.00339905182906 | 0.428571428571 | NUP210 NUP155 NDC1 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.00357489216687 | 0.428571428571 | NUP210 NUP155 NDC1 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.00375664335928 | 0.428571428571 | NUP210 NUP155 NDC1 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.0040405592933 | 0.428571428571 | NUP210 NUP155 NDC1 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00454464074576 | 0.428571428571 | NUP210 NUP155 NDC1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.00465019583743 | 0.428571428571 | NUP210 NUP155 NDC1 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-5619115 | 0.00579605132299 | 0.428571428571 | NUP210 NUP155 NDC1 | Disorders of transmembrane transporters |
| REAC:R-HSA-162587 | 0.00591992337161 | 0.428571428571 | NUP210 NUP155 NDC1 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 0.00591992337161 | 0.428571428571 | NUP210 NUP155 NDC1 | HCMV Infection |
| REAC:R-HSA-168255 | 0.00669999275154 | 0.428571428571 | NUP210 NUP155 NDC1 | Influenza Infection |
| REAC:R-HSA-3108232 | 0.00814566466165 | 0.428571428571 | NUP210 NUP155 NDC1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-69278 | 0.0103191476058 | 0.571428571429 | NUP155 AHCTF1 NDC1 NUP210 | Cell Cycle, Mitotic |
| REAC:R-HSA-913531 | 0.0110497496792 | 0.428571428571 | NUP210 NUP155 NDC1 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.0136792933871 | 0.428571428571 | NUP210 NUP155 NDC1 | SARS-CoV-2-host interactions |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | NUP155 SENP2 NDC1 SENP1 NUP210 | Post-translational protein modification |
| KEGG:05014 | 0.0184567258965 | 0.428571428571 | NUP210 NUP155 NDC1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-162906 | 0.0221229571183 | 0.428571428571 | NUP210 NUP155 NDC1 | HIV Infection |
| REAC:R-HSA-68882 | 0.022722403222 | 0.428571428571 | AHCTF1 NUP155 NDC1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0230260807304 | 0.428571428571 | AHCTF1 NUP155 NDC1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | NUP155 AHCTF1 NDC1 NUP210 | Cell Cycle |
| REAC:R-HSA-71387 | 0.0342016128619 | 0.428571428571 | NUP210 NUP155 NDC1 | Metabolism of carbohydrates |
| REAC:R-HSA-9694516 | 0.0413619740567 | 0.428571428571 | NUP210 NUP155 NDC1 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 0.0418111738628 | 0.428571428571 | NUP210 NUP155 NDC1 | Processing of Capped Intron-Containing Pre-mRNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDC1 | SMPD4 | 0.998 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AHCTF1 | SMPD4 | 0.995 | 0.102 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUP155 | NDC1 | 0.986 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| SMPD4 | SENP1 | 0.982 | 0.066 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SENP2 | NDC1 | 0.98 | 0.086 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NUP210 | SMPD4 | 0.977 | 0.082 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| SENP2 | SMPD4 | 0.973 | 0.048 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NDC1 | SENP1 | 0.969 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AHCTF1 | NUP210 | 0.966 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| SENP2 | SENP1 | 0.961 | 0.094 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| SENP2 | NUP155 | 0.959 | 0.15 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NDC1 | AHCTF1 | 0.958 | 0.248 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUP155 | SMPD4 | 0.958 | 0.454 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NDC1 | NUP210 | 0.948 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SENP2 | NUP210 | 0.941 | 0.066 | hein_WMM youn_WMM WMM_only |
| NUP155 | SENP1 | 0.888 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AHCTF1 | SENP1 | 0.883 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUP210 | SENP1 | 0.793 | 0.098 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| SENP2 | AHCTF1 | 0.583 | 0.152 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUP155 | NUP210 | 0.54 | 0.276 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| NUP155 | AHCTF1 | 0.391 | 0.592 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes