hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07649.1
Complex Portal: CPX-24954
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| SUMO3 | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 5 | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065678 | 1.75410211812e-16 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 3.68361444806e-15 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | Processing and activation of SUMO |
| REAC:R-HSA-3065676 | 2.13564856385e-12 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-2990846 | 2.63492330395e-08 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | SUMOylation |
| GO:0016925 | 3.13241237978e-08 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | protein sumoylation |
| REAC:R-HSA-3232118 | 1.41820648707e-06 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of transcription factors |
| GO:0018205 | 1.5086832866e-06 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | peptidyl-lysine modification |
| REAC:R-HSA-4090294 | 2.11908198931e-06 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of intracellular receptors |
| GO:0044388 | 9.61003071434e-06 | 0.6 | UBE2I SAE1 UBA2 | small protein activating enzyme binding |
| CORUM:5756 | 1.36501667663e-05 | 0.4 | UBA2 SAE1 | SUA1-UBA2 complex |
| REAC:R-HSA-3899300 | 2.62324018845e-05 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of transcription cofactors |
| REAC:R-HSA-5696395 | 3.5683276241e-05 | 0.6 | UBE2I SUMO2 SUMO3 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-4615885 | 3.5683276241e-05 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of DNA replication proteins |
| CORUM:5755 | 4.09448956317e-05 | 0.4 | UBA2 SAE1 | SUMO1-SUA1-UBA2 complex |
| HPA:0470673 | 0.000128520535481 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; melanocytes[High] |
| REAC:R-HSA-4551638 | 0.000141884912451 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of chromatin organization proteins |
| KEGG:03013 | 0.000153958097406 | 0.6 | UBE2I SUMO2 SUMO3 | Nucleocytoplasmic transport |
| REAC:R-HSA-3108214 | 0.000177125385704 | 0.6 | UBE2I SUMO2 SUMO3 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-3065679 | 0.000227895019208 | 0.4 | SUMO2 SUMO3 | SUMO is proteolytically processed |
| REAC:R-HSA-5696399 | 0.000284390695808 | 0.6 | UBE2I SUMO2 SUMO3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| KEGG:04120 | 0.00036915769815 | 0.6 | UBE2I SAE1 UBA2 | Ubiquitin mediated proteolysis |
| HPA:0471493 | 0.000498798374019 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; vascular mural cells[High] |
| GO:0033233 | 0.000537554131189 | 0.6 | UBE2I SAE1 UBA2 | regulation of protein sumoylation |
| HPA:0461493 | 0.00060300411182 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; vascular mural cells[High] |
| REAC:R-HSA-5696398 | 0.000630278165562 | 0.6 | UBE2I SUMO2 SUMO3 | Nucleotide Excision Repair |
| HPA:0460182 | 0.000678709436793 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 1; cells in granular layer[>=Medium] |
| REAC:R-HSA-196791 | 0.000683310775372 | 0.4 | UBE2I SUMO2 | Vitamin D (calciferol) metabolism |
| REAC:R-HSA-4755510 | 0.000683310775372 | 0.4 | UBE2I SUMO3 | SUMOylation of immune response proteins |
| REAC:R-HSA-597592 | 0.000685877408784 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | Post-translational protein modification |
| HPA:0470202 | 0.00118125982621 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; endothelial cells[>=Medium] |
| HPA:0470672 | 0.00127801670844 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; melanocytes[>=Medium] |
| HPA:0461492 | 0.00161900343633 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; vascular mural cells[>=Medium] |
| HPA:0471492 | 0.00167292187702 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; vascular mural cells[>=Medium] |
| HPA:0461393 | 0.00167292187702 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; cells in basal layer[High] |
| HPA:0460181 | 0.00180973618749 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.00183134834989 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; cells in granular layer[>=Low] |
| REAC:R-HSA-3108232 | 0.0019808748776 | 0.6 | UBE2I SUMO2 SUMO3 | SUMO E3 ligases SUMOylate target proteins |
| HPA:0461413 | 0.00208397740023 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; cells in spinous layer[High] |
| HPA:0470671 | 0.00209394959887 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; melanocytes[>=Low] |
| HPA:0461463 | 0.00241521762684 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; langerhans cells[High] |
| HPA:0471461 | 0.00277537397964 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; langerhans cells[>=Low] |
| HPA:0471491 | 0.00326258955925 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; vascular mural cells[>=Low] |
| HPA:0460183 | 0.00334812702156 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; cells in granular layer[High] |
| HPA:0470183 | 0.00339144619884 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; cells in granular layer[High] |
| HPA:0461491 | 0.00339144619884 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; vascular mural cells[>=Low] |
| REAC:R-HSA-392499 | 0.00352060064826 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | Metabolism of proteins |
| HPA:0471413 | 0.00356842784326 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; cells in spinous layer[High] |
| GO:0018193 | 0.00398694299862 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | peptidyl-amino acid modification |
| HPA:0471411 | 0.00412014949722 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; cells in spinous layer[>=Low] |
| HPA:0471463 | 0.00433732325393 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; langerhans cells[High] |
| HPA:0470201 | 0.00438427065649 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | skin 2; endothelial cells[>=Low] |
| GO:0019948 | 0.00468200720083 | 0.4 | UBA2 SAE1 | SUMO activating enzyme activity |
| GO:0031510 | 0.00468200720083 | 0.4 | UBA2 SAE1 | SUMO activating enzyme complex |
| GO:0032446 | 0.00518507269481 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | protein modification by small protein conjugation |
| HPA:0471393 | 0.00605918446772 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; cells in basal layer[High] |
| WP:WP5362 | 0.00687274586933 | 0.4 | UBE2I SUMO2 | TAR syndrome |
| HPA:0460203 | 0.00713826887462 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; endothelial cells[High] |
| HPA:0470203 | 0.00728144353478 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; endothelial cells[High] |
| REAC:R-HSA-4085377 | 0.00750894366662 | 0.4 | UBE2I SUMO2 | SUMOylation of SUMOylation proteins |
| GO:0070647 | 0.00850725222417 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | protein modification by small protein conjugation or removal |
| GO:0043687 | 0.0118211242494 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | post-translational protein modification |
| HPA:0630053 | 0.0120291616551 | 0.8 | UBA2 UBE2I SUMO2 SUMO3 | cervix; glandular cells[High] |
| HPA:0461473 | 0.0133449870931 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; lymphocytes[High] |
| REAC:R-HSA-4570464 | 0.0136499247655 | 0.4 | UBE2I SUMO2 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | UBE2I SUMO2 SUMO3 | DNA Repair |
| HPA:0461443 | 0.0147897127468 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; fibrohistiocytic cells[High] |
| HPA:0030072 | 0.0188314494581 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | appendix; lymphoid tissue[>=Medium] |
| HPA:0471473 | 0.0212982616684 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; lymphocytes[High] |
| HPA:0471443 | 0.0223365489821 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; fibrohistiocytic cells[High] |
| HPA:0570813 | 0.0224403274321 | 0.8 | SUMO3 UBA2 SAE1 SUMO2 | testis; spermatogonia cells[High] |
| HPA:0510653 | 0.0290892096992 | 0.6 | UBA2 SUMO2 SUMO3 | soft tissue 2; fibroblasts[High] |
| KEGG:05418 | 0.0303640260346 | 0.4 | SUMO2 SUMO3 | Fluid shear stress and atherosclerosis |
| HPA:0500653 | 0.0330123883704 | 0.6 | UBA2 SUMO2 SUMO3 | soft tissue 1; fibroblasts[High] |
| HPA:0470182 | 0.037477729829 | 0.6 | UBA2 SUMO2 SUMO3 | skin 2; cells in granular layer[>=Medium] |
| HPA:0170251 | 0.0422298811316 | 1.0 | SUMO3 UBE2I UBA2 SAE1 SUMO2 | endometrium 2; cells in endometrial stroma[>=Low] |
| HPA:0461472 | 0.0423206374997 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; lymphocytes[>=Medium] |
| HPA:0461462 | 0.0444139015161 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; langerhans cells[>=Medium] |
| HPA:0460202 | 0.0460879152407 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.0463303695681 | 0.6 | UBA2 SUMO2 SUMO3 | skin 1; cells in spinous layer[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBA2 | UBE2I | 1.0 | 0.322 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| SUMO2 | UBE2I | 0.999 | 0.436 |
structurally_consistent (Q9UBT2)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| SAE1 | UBE2I | 0.999 | 0.294 |
structurally_consistent (Q9UBT2)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| SAE1 | UBA2 | 0.998 | 0.936 |
mutually_exclusive (P61956)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SUMO2 | UBA2 | 0.994 | 0.486 |
mutually_exclusive (Q9UBE0)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| SUMO2 | SAE1 | 0.99 | 0.408 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| UBE2I | SUMO3 | 0.988 | 0.142 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| SUMO2 | SUMO3 | 0.929 | 0.33 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| SAE1 | SUMO3 | 0.928 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction | |
| UBA2 | SUMO3 | 0.349 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes