hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07657.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | 5 | UniProt NCBI |
| ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | 5 | UniProt NCBI |
| MTFR1 | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | 4 | UniProt NCBI |
| TESPA1 | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | 5 | UniProt NCBI |
| IRAG1 | Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1) | 5 | UniProt NCBI |
| ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | 5 | UniProt NCBI |
| ITPRID2 | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | 5 | UniProt NCBI |
| BOK | Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031095 | 2.31823352537e-07 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | platelet dense tubular network membrane |
| GO:0031094 | 6.06890408176e-07 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | platelet dense tubular network |
| REAC:R-HSA-5607763 | 1.92107583885e-06 | 0.375 | ITPR2 ITPR3 ITPR1 | CLEC7A (Dectin-1) induces NFAT activation |
| REAC:R-HSA-139853 | 5.02751533314e-06 | 0.375 | ITPR2 ITPR3 ITPR1 | Elevation of cytosolic Ca2+ levels |
| GO:0005220 | 5.38272230028e-06 | 0.375 | ITPR2 ITPR3 ITPR1 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| KEGG:04270 | 5.93696614889e-06 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | Vascular smooth muscle contraction |
| REAC:R-HSA-418346 | 7.94405385637e-06 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | Platelet homeostasis |
| REAC:R-HSA-5218921 | 8.313982098e-06 | 0.375 | ITPR2 ITPR3 ITPR1 | VEGFR2 mediated cell proliferation |
| KEGG:04022 | 1.72100778664e-05 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | cGMP-PKG signaling pathway |
| REAC:R-HSA-2871809 | 2.21041516255e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | FCERI mediated Ca+2 mobilization |
| WP:WP4698 | 2.85542545019e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Vitamin D sensitive calcium signaling in depression |
| REAC:R-HSA-2029485 | 3.03234516525e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-983695 | 3.51023480424e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| REAC:R-HSA-418360 | 4.03573329385e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Platelet calcium homeostasis |
| REAC:R-HSA-114508 | 4.03573329385e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Effects of PIP2 hydrolysis |
| WP:WP4756 | 5.83116661483e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Renin angiotensin aldosterone system RAAS |
| KEGG:04927 | 6.05720138325e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Cortisol synthesis and secretion |
| KEGG:04929 | 7.48130919038e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | GnRH secretion |
| KEGG:04924 | 9.11183676069e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Renin secretion |
| KEGG:04730 | 9.11183676069e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | Long-term depression |
| REAC:R-HSA-9664323 | 9.23525641109e-05 | 0.375 | ITPR2 ITPR3 ITPR1 | FCGR3A-mediated IL10 synthesis |
| KEGG:04971 | 0.000123253724587 | 0.375 | ITPR2 ITPR3 ITPR1 | Gastric acid secretion |
| KEGG:04720 | 0.000130470388312 | 0.375 | ITPR2 ITPR3 ITPR1 | Long-term potentiation |
| REAC:R-HSA-381676 | 0.000148687552241 | 0.375 | ITPR2 ITPR3 ITPR1 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-1489509 | 0.000162162924374 | 0.375 | ITPR2 ITPR3 ITPR1 | DAG and IP3 signaling |
| KEGG:04918 | 0.000179721512345 | 0.375 | ITPR2 ITPR3 ITPR1 | Thyroid hormone synthesis |
| KEGG:04970 | 0.000218591945747 | 0.375 | ITPR2 ITPR3 ITPR1 | Salivary secretion |
| REAC:R-HSA-5578775 | 0.000241797870321 | 0.375 | ITPR2 ITPR3 ITPR1 | Ion homeostasis |
| REAC:R-HSA-112043 | 0.000260330782854 | 0.375 | ITPR2 ITPR3 ITPR1 | PLC beta mediated events |
| KEGG:04912 | 0.000262665274355 | 0.375 | ITPR2 ITPR3 ITPR1 | GnRH signaling pathway |
| KEGG:04750 | 0.000274533958445 | 0.375 | ITPR2 ITPR3 ITPR1 | Inflammatory mediator regulation of TRP channels |
| WP:WP5356 | 0.000283445979884 | 0.375 | ITPR2 ITPR3 ITPR1 | Affected pathways in Duchenne muscular dystrophy |
| KEGG:04540 | 0.000299326553564 | 0.375 | ITPR2 ITPR3 ITPR1 | Gap junction |
| GO:0070679 | 0.000301045822538 | 0.375 | ITPR2 ITPR3 ITPR1 | inositol 1,4,5 trisphosphate binding |
| KEGG:04972 | 0.000312260387677 | 0.375 | ITPR2 ITPR3 ITPR1 | Pancreatic secretion |
| KEGG:04925 | 0.000339227897214 | 0.375 | ITPR2 ITPR3 ITPR1 | Aldosterone synthesis and secretion |
| REAC:R-HSA-112040 | 0.000367233569698 | 0.375 | ITPR2 ITPR3 ITPR1 | G-protein mediated events |
| KEGG:04724 | 0.000445680989864 | 0.375 | ITPR2 ITPR3 ITPR1 | Glutamatergic synapse |
| KEGG:04928 | 0.000479706248535 | 0.375 | ITPR2 ITPR3 ITPR1 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04726 | 0.000497345091308 | 0.375 | ITPR2 ITPR3 ITPR1 | Serotonergic synapse |
| KEGG:04070 | 0.000515407932342 | 0.375 | ITPR2 ITPR3 ITPR1 | Phosphatidylinositol signaling system |
| KEGG:04625 | 0.000515407932342 | 0.375 | ITPR2 ITPR3 ITPR1 | C-type lectin receptor signaling pathway |
| REAC:R-HSA-4086398 | 0.000529728773758 | 0.375 | ITPR2 ITPR3 ITPR1 | Ca2+ pathway |
| KEGG:04725 | 0.000591996909499 | 0.375 | ITPR2 ITPR3 ITPR1 | Cholinergic synapse |
| KEGG:04922 | 0.000654129489706 | 0.375 | ITPR2 ITPR3 ITPR1 | Glucagon signaling pathway |
| KEGG:04915 | 0.000654129489706 | 0.375 | ITPR2 ITPR3 ITPR1 | Estrogen signaling pathway |
| KEGG:04611 | 0.000791024458035 | 0.375 | ITPR2 ITPR3 ITPR1 | Platelet activation |
| KEGG:04935 | 0.000840540018666 | 0.375 | ITPR2 ITPR3 ITPR1 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-9664433 | 0.000853240910983 | 0.375 | ITPR2 ITPR3 ITPR1 | Leishmania parasite growth and survival |
| REAC:R-HSA-9662851 | 0.000853240910983 | 0.375 | ITPR2 ITPR3 ITPR1 | Anti-inflammatory response favouring Leishmania parasite infection |
| KEGG:04114 | 0.00094562799903 | 0.375 | ITPR2 ITPR3 ITPR1 | Oocyte meiosis |
| REAC:R-HSA-422356 | 0.000984685646855 | 0.375 | ITPR2 ITPR3 ITPR1 | Regulation of insulin secretion |
| KEGG:04728 | 0.00108873980413 | 0.375 | ITPR2 ITPR3 ITPR1 | Dopaminergic synapse |
| KEGG:04371 | 0.00114976317669 | 0.375 | ITPR2 ITPR3 ITPR1 | Apelin signaling pathway |
| GO:0015278 | 0.00118146610329 | 0.375 | ITPR2 ITPR3 ITPR1 | calcium-release channel activity |
| KEGG:04380 | 0.00127849680123 | 0.375 | ITPR2 ITPR3 ITPR1 | Osteoclast differentiation |
| KEGG:04921 | 0.00138104723444 | 0.375 | ITPR2 ITPR3 ITPR1 | Oxytocin signaling pathway |
| KEGG:04723 | 0.00141639880227 | 0.375 | ITPR2 ITPR3 ITPR1 | Retrograde endocannabinoid signaling |
| KEGG:04210 | 0.00145234226842 | 0.375 | ITPR2 ITPR3 ITPR1 | Apoptosis |
| KEGG:05017 | 0.00164110254365 | 0.375 | ITPR2 ITPR3 ITPR1 | Spinocerebellar ataxia |
| KEGG:04934 | 0.00164110254365 | 0.375 | ITPR2 ITPR3 ITPR1 | Cushing syndrome |
| REAC:R-HSA-2029480 | 0.00170926663203 | 0.375 | ITPR2 ITPR3 ITPR1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-111885 | 0.00170926663203 | 0.375 | ITPR2 ITPR3 ITPR1 | Opioid Signalling |
| WP:WP536 | 0.00217685153806 | 0.375 | ITPR2 ITPR3 ITPR1 | Calcium regulation in cardiac cells |
| REAC:R-HSA-5576891 | 0.00221515749645 | 0.375 | ITPR2 ITPR3 ITPR1 | Cardiac conduction |
| KEGG:04218 | 0.00230271739071 | 0.375 | ITPR2 ITPR3 ITPR1 | Cellular senescence |
| REAC:R-HSA-4420097 | 0.00237597190289 | 0.375 | ITPR2 ITPR3 ITPR1 | VEGFA-VEGFR2 Pathway |
| KEGG:04621 | 0.00260993521755 | 0.375 | ITPR2 ITPR3 ITPR1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5607764 | 0.00263138488572 | 0.375 | ITPR2 ITPR3 ITPR1 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-163685 | 0.00272039056422 | 0.375 | ITPR2 ITPR3 ITPR1 | Integration of energy metabolism |
| REAC:R-HSA-194138 | 0.00309630954826 | 0.375 | ITPR2 ITPR3 ITPR1 | Signaling by VEGF |
| REAC:R-HSA-983705 | 0.00319536739425 | 0.375 | ITPR2 ITPR3 ITPR1 | Signaling by the B Cell Receptor (BCR) |
| WP:WP289 | 0.00347994291534 | 0.375 | ITPR2 ITPR3 ITPR1 | Myometrial relaxation and contraction pathways |
| REAC:R-HSA-418457 | 0.00367178411278 | 0.25 | ITPR1 IRAG1 | cGMP effects |
| KEGG:05167 | 0.00396473051169 | 0.375 | ITPR2 ITPR3 ITPR1 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04020 | 0.00425211135478 | 0.375 | ITPR2 ITPR3 ITPR1 | Calcium signaling pathway |
| GO:0099604 | 0.0043754188034 | 0.375 | ITPR2 ITPR3 ITPR1 | ligand-gated calcium channel activity |
| REAC:R-HSA-2454202 | 0.00494153535515 | 0.375 | ITPR2 ITPR3 ITPR1 | Fc epsilon receptor (FCERI) signaling |
| KEGG:05205 | 0.0050295788442 | 0.375 | ITPR2 ITPR3 ITPR1 | Proteoglycans in cancer |
| KEGG:05163 | 0.00589487948597 | 0.375 | ITPR2 ITPR3 ITPR1 | Human cytomegalovirus infection |
| KEGG:05170 | 0.00598640884546 | 0.375 | ITPR2 ITPR3 ITPR1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-5621481 | 0.00624198166425 | 0.375 | ITPR2 ITPR3 ITPR1 | C-type lectin receptors (CLRs) |
| GO:0005217 | 0.00712601113833 | 0.375 | ITPR2 ITPR3 ITPR1 | intracellular ligand-gated monoatomic ion channel activity |
| REAC:R-HSA-392154 | 0.00755574884395 | 0.25 | ITPR1 IRAG1 | Nitric oxide stimulates guanylate cyclase |
| REAC:R-HSA-416476 | 0.00811493071322 | 0.375 | ITPR2 ITPR3 ITPR1 | G alpha (q) signalling events |
| REAC:R-HSA-9824443 | 0.00907607024649 | 0.375 | ITPR2 ITPR3 ITPR1 | Parasitic Infection Pathways |
| REAC:R-HSA-3858494 | 0.00907607024649 | 0.375 | ITPR2 ITPR3 ITPR1 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9658195 | 0.00907607024649 | 0.375 | ITPR2 ITPR3 ITPR1 | Leishmania infection |
| KEGG:05131 | 0.00967769141743 | 0.375 | ITPR2 ITPR3 ITPR1 | Shigellosis |
| KEGG:05012 | 0.0111289834178 | 0.375 | ITPR2 ITPR3 ITPR1 | Parkinson disease |
| KEGG:05020 | 0.0121225246333 | 0.375 | ITPR2 ITPR3 ITPR1 | Prion disease |
| REAC:R-HSA-397014 | 0.012158802958 | 0.375 | ITPR2 ITPR3 ITPR1 | Muscle contraction |
| WP:WP2059 | 0.0187811159917 | 0.375 | ITPR2 ITPR3 ITPR1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0187811159917 | 0.375 | ITPR2 ITPR3 ITPR1 | Alzheimer 39 s disease |
| REAC:R-HSA-109582 | 0.0218504105027 | 0.5 | IRAG1 ITPR2 ITPR3 ITPR1 | Hemostasis |
| REAC:R-HSA-418594 | 0.0230577137206 | 0.375 | ITPR2 ITPR3 ITPR1 | G alpha (i) signalling events |
| KEGG:05010 | 0.0317191137546 | 0.375 | ITPR2 ITPR3 ITPR1 | Alzheimer disease |
| KEGG:04713 | 0.0334539586856 | 0.25 | ITPR1 ITPR3 | Circadian entrainment |
| GO:0016529 | 0.0349415747767 | 0.375 | ITPR2 ITPR3 ITPR1 | sarcoplasmic reticulum |
| REAC:R-HSA-76002 | 0.0364069504951 | 0.375 | ITPR2 ITPR3 ITPR1 | Platelet activation, signaling and aggregation |
| GO:0016528 | 0.0487399472212 | 0.375 | ITPR2 ITPR3 ITPR1 | sarcoplasm |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IRAG1 | BOK | 1.0 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITPR2 | ITPR3 | 0.999 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ITPR1 | TESPA1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TESPA1 | BOK | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITPR2 | TESPA1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITPR1 | ITPR3 | 0.998 | 0.486 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ITPR1 | IRAG1 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TESPA1 | ITPR3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITPR2 | ITPRID2 | 0.997 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITPR3 | ITPRID2 | 0.997 | 0.066 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITPR2 | ITPR1 | 0.996 | 0.206 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ITPR2 | IRAG1 | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IRAG1 | ITPR3 | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITPR1 | ITPRID2 | 0.99 | 0.0546666666667 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITPR3 | MTFR1 | 0.975 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITPR1 | MTFR1 | 0.975 | 0.06 | hein_WMM bioplex3_WMM WMM_only |
| ITPR1 | BOK | 0.961 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITPRID2 | MTFR1 | 0.958 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TESPA1 | ITPRID2 | 0.956 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITPR2 | BOK | 0.95 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITPR3 | BOK | 0.95 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRAG1 | ITPRID2 | 0.948 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BOK | ITPRID2 | 0.917 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITPR2 | MTFR1 | 0.875 | 0.078 | hein_WMM bioplex3_WMM WMM_only |
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