hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07661.1
Complex Portal: CPX-17990
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | 5 | UniProt NCBI |
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| PAIP1 | Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) | 5 | UniProt NCBI |
| MKRN3 | Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) | 5 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
| PAIP2 | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | 5 | UniProt NCBI |
| MKRN1 | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 8.74819058584e-06 | 0.444444444444 | NCBP1 GSPT2 PABPC1L ETF1 | mRNA surveillance pathway |
| WP:WP107 | 0.000267632290568 | 0.333333333333 | ETF1 GSPT2 PAIP1 | Translation factors |
| GO:0003723 | 0.00286771858791 | 0.888888888889 | MKRN3 ETF1 MKRN2 GSPT2 NCBP1 PAIP1 MKRN1 PABPC1L | RNA binding |
| REAC:R-HSA-975956 | 0.0049873114417 | 0.333333333333 | NCBP1 GSPT2 ETF1 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-975957 | 0.00889169623462 | 0.333333333333 | NCBP1 GSPT2 ETF1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.00889169623462 | 0.333333333333 | NCBP1 GSPT2 ETF1 | Nonsense-Mediated Decay (NMD) |
| GO:0045182 | 0.0185915423503 | 0.444444444444 | ETF1 PAIP2 GSPT2 PAIP1 | translation regulator activity |
| REAC:R-HSA-9010553 | 0.0272414852694 | 0.333333333333 | NCBP1 GSPT2 ETF1 | Regulation of expression of SLITs and ROBOs |
| CORUM:809 | 0.0499842271994 | 0.111111111111 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAIP1 | PAIP2 | 0.999 | 0.08 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NCBP1 | PAIP1 | 0.995 | 0.114 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| GSPT2 | MKRN3 | 0.994 | 0.064 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAIP1 | MKRN1 | 0.99 | 0.0713333333333 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MKRN1 | GSPT2 | 0.987 | 0.09 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NCBP1 | GSPT2 | 0.987 | 0.234 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| GSPT2 | ETF1 | 0.987 | 0.686 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PAIP1 | MKRN2 | 0.982 | 0.232 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PAIP1 | MKRN3 | 0.978 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MKRN2 | PAIP2 | 0.973 | 0.128 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PAIP1 | GSPT2 | 0.961 | 0.246 |
mutually_exclusive (P0CB38)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| NCBP1 | MKRN1 | 0.951 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MKRN2 | MKRN1 | 0.944 | 0.106 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GSPT2 | PAIP2 | 0.915 | 0.17 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NCBP1 | MKRN2 | 0.848 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MKRN1 | PAIP2 | 0.831 | 0.128 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCBP1 | PAIP2 | 0.824 | 0.074 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCBP1 | MKRN3 | 0.736 | 0.082 | bioplex3_WMM WMM_only | |
| MKRN1 | MKRN3 | 0.736 | 0.1 | bioplex3_WMM WMM_only | |
| PAIP2 | MKRN3 | 0.689 | 0.106 | bioplex3_WMM WMM_only | |
| MKRN2 | MKRN3 | 0.561 | 0.134 | bioplex3_WMM WMM_only | |
| MKRN2 | ETF1 | 0.025 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MKRN1 | ETF1 | 0.009 | 0.136 | bioplex3_WMM youn_WMM WMM_only | |
| ETF1 | PAIP2 | 0.007 | 0.178 | youn () bioplex3_WMM youn_WMM WMM_only | |
| ETF1 | MKRN3 | 0.006 | 0.038 | bioplex3_WMM WMM_only | |
| PAIP1 | ETF1 | 0.003 | 0.252 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NCBP1 | ETF1 | 0.001 | 0.44 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
Related Complexes