hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07665.1
Complex Portal: CPX-17543
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TXNDC16 | Thioredoxin domain-containing protein 16 | 5 | UniProt NCBI |
| FKBP10 | Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) | 5 | UniProt NCBI |
| PDIA4 | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | 5 | UniProt NCBI |
| SDF2 | Stromal cell-derived factor 2 (SDF-2) | 3 | UniProt NCBI |
| ERLEC1 | Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein) | 5 | UniProt NCBI |
| OLFM2 | Noelin-2 (Olfactomedin-2) | 5 | UniProt NCBI |
| OS9 | Protein OS-9 (Amplified in osteosarcoma 9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6859 | 0.000938276380634 | 0.333333333333 | ERLEC1 OS9 | HRD1 complex |
| REAC:R-HSA-5362768 | 0.03659902859 | 0.333333333333 | ERLEC1 OS9 | Hh mutants are degraded by ERAD |
| REAC:R-HSA-5387390 | 0.0379731829042 | 0.333333333333 | ERLEC1 OS9 | Hh mutants abrogate ligand secretion |
| REAC:R-HSA-5358346 | 0.0422459670228 | 0.333333333333 | ERLEC1 OS9 | Hedgehog ligand biogenesis |
| REAC:R-HSA-5678895 | 0.0437202891307 | 0.333333333333 | ERLEC1 OS9 | Defective CFTR causes cystic fibrosis |
| HPA:0380513 | 0.0446933566325 | 0.666666666667 | FKBP10 OS9 TXNDC16 ERLEC1 | placenta; decidual cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OS9 | ERLEC1 | 0.997 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM boldt_WMM | |
| OLFM2 | OS9 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FKBP10 | OS9 | 0.98 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| FKBP10 | PDIA4 | 0.975 | 0.312 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM treiber_WMM | |
| OLFM2 | SDF2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PDIA4 | OS9 | 0.962 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| TXNDC16 | OS9 | 0.96 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| OLFM2 | PDIA4 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FKBP10 | ERLEC1 | 0.951 | 0.0962732240437 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| SDF2 | OS9 | 0.921 | 0.03 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| PDIA4 | ERLEC1 | 0.916 | 0.348 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| OLFM2 | ERLEC1 | 0.889 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TXNDC16 | ERLEC1 | 0.882 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| TXNDC16 | PDIA4 | 0.806 | 0.132 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| TXNDC16 | OLFM2 | 0.788 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SDF2 | ERLEC1 | 0.723 | 0.192 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| TXNDC16 | SDF2 | 0.607 | 0.054 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| FKBP10 | OLFM2 | 0.596 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| FKBP10 | SDF2 | 0.519 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| TXNDC16 | FKBP10 | 0.503 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PDIA4 | SDF2 | 0.36 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes