hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07679.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
| ESYT1 | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP698 | 2.84994785564e-07 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Glucuronidation |
| KEGG:00053 | 5.28144662807e-07 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Ascorbate and aldarate metabolism |
| REAC:R-HSA-156588 | 7.85274543963e-07 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Glucuronidation |
| KEGG:00040 | 7.88665904961e-07 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Pentose and glucuronate interconversions |
| GO:0051552 | 1.53784171933e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | flavone metabolic process |
| KEGG:00860 | 1.87008360524e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Porphyrin metabolism |
| KEGG:00140 | 3.38522311544e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Steroid hormone biosynthesis |
| KEGG:00830 | 7.13131503768e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Retinol metabolism |
| KEGG:05204 | 8.02117619688e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 8.49257304271e-06 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 1.0562525866e-05 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Bile secretion |
| KEGG:00980 | 1.11278026553e-05 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Metabolism of xenobiotics by cytochrome P450 |
| GO:0009812 | 1.34540429244e-05 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | flavonoid metabolic process |
| KEGG:00983 | 1.63910874597e-05 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Drug metabolism - other enzymes |
| WP:WP5224 | 6.51793730149e-05 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | 2q37 copy number variation syndrome |
| REAC:R-HSA-156580 | 0.000114832276301 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Phase II - Conjugation of compounds |
| WP:WP1604 | 0.000114838123418 | 0.5 | UGT1A10 UGT1A8 | Codeine and morphine metabolism |
| REAC:R-HSA-9748784 | 0.000119242757257 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Drug ADME |
| KEGG:01240 | 0.000133691874029 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Biosynthesis of cofactors |
| GO:0052695 | 0.000139871762976 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | cellular glucuronidation |
| GO:0019585 | 0.000174830724535 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | glucuronate metabolic process |
| GO:0006063 | 0.000174830724535 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | uronic acid metabolic process |
| WP:WP691 | 0.000232143427839 | 0.5 | UGT1A10 UGT1A8 | Tamoxifen metabolism |
| KEGG:05207 | 0.000241241390361 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Chemical carcinogenesis - receptor activation |
| WP:WP5276 | 0.000535373329556 | 0.5 | UGT1A10 UGT1A8 | Estrogen metabolism |
| GO:0015020 | 0.000777349058504 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | glucuronosyltransferase activity |
| REAC:R-HSA-211859 | 0.000986096194174 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | Biological oxidations |
| GO:0001889 | 0.00298219742351 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | liver development |
| GO:0061008 | 0.00323764786551 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | hepaticobiliary system development |
| REAC:R-HSA-9749641 | 0.00444848198459 | 0.5 | UGT1A8 UGT1A7 | Aspirin ADME |
| GO:0042440 | 0.0079870728422 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | pigment metabolic process |
| GO:0052696 | 0.0168521501606 | 0.5 | UGT1A8 UGT1A7 | flavonoid glucuronidation |
| WP:WP702 | 0.0228199530946 | 0.5 | UGT1A10 UGT1A7 | Metapathway biotransformation Phase I and II |
| CORUM:7314 | 0.0249718442456 | 0.25 | ESYT1 | ESYT1-ESYT3 complex |
| GO:0009804 | 0.0280843539964 | 0.5 | UGT1A8 UGT1A7 | coumarin metabolic process |
| GO:0009698 | 0.0280843539964 | 0.5 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | ESYT1 UGT1A10 UGT1A7 UGT1A8 | Metabolism |
| GO:0006805 | 0.0405772675542 | 0.75 | UGT1A10 UGT1A7 UGT1A8 | xenobiotic metabolic process |
| GO:0052697 | 0.042122686785 | 0.5 | UGT1A8 UGT1A7 | xenobiotic glucuronidation |
| CORUM:7313 | 0.049938562206 | 0.25 | ESYT1 | ESYT1-ESYT2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A7 | ESYT1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | ESYT1 | 0.206 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UGT1A10 | ESYT1 | 0.049 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes