hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07695.1
Complex Portal: CPX-14147
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDR87 | WD repeat-containing protein 87 (Testis development protein NYD-SP11) | 3 | UniProt NCBI |
| SETD5 | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | 5 | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | 5 | UniProt NCBI |
| NCOR2 | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | 5 | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | 5 | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | 5 | UniProt NCBI |
| TBL1X | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9022537 | 3.22548169728e-14 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| REAC:R-HSA-9697154 | 1.35346625055e-12 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Disorders of Nervous System Development |
| REAC:R-HSA-9005891 | 1.35346625055e-12 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9005895 | 1.35346625055e-12 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Pervasive developmental disorders |
| REAC:R-HSA-9675151 | 1.35346625055e-12 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Disorders of Developmental Biology |
| CORUM:58 | 2.69032781214e-11 | 0.444444444444 | TBL1XR1 TBL1X NCOR2 GPS2 | SMRT complex |
| CORUM:741 | 2.69032781214e-11 | 0.444444444444 | NCOR1 GPS2 TBL1X TBL1XR1 | NCOR-HDAC3 complex |
| CORUM:15 | 8.068773772e-11 | 0.444444444444 | NCOR1 GPS2 TBL1X TBL1XR1 | NCOR complex |
| REAC:R-HSA-9022692 | 6.35059719407e-10 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 9.0820881057e-10 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| CORUM:2183 | 1.12839162173e-09 | 0.444444444444 | NCOR1 GPS2 TBL1X TBL1XR1 | Kaiso-NCOR complex |
| WP:WP4312 | 1.74636239523e-09 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Rett syndrome causing genes |
| REAC:R-HSA-9024446 | 3.07191674153e-09 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 1.52620946243e-08 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-350054 | 1.14373512426e-07 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Notch-HLH transcription pathway |
| REAC:R-HSA-3214815 | 1.27066333918e-07 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | HDACs deacetylate histones |
| REAC:R-HSA-1989781 | 3.76401385349e-07 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 3.96121142134e-07 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Regulation of lipid metabolism by PPARalpha |
| REAC:R-HSA-9609690 | 9.98125265684e-07 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | HCMV Early Events |
| REAC:R-HSA-2122947 | 1.4218926471e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9609646 | 2.33488700563e-06 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | HCMV Infection |
| REAC:R-HSA-2894858 | 2.76977126814e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 2.76977126814e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644602 | 2.76977126814e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 2.76977126814e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 2.76977126814e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| GO:0017053 | 5.13607866526e-06 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | transcription repressor complex |
| GO:0003714 | 6.16717057768e-06 | 0.666666666667 | NCOR1 TBL1Y NCOR2 GPS2 TBL1XR1 TBL1X | transcription corepressor activity |
| REAC:R-HSA-9707564 | 7.04426707928e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Cytoprotection by HMOX1 |
| REAC:R-HSA-1980143 | 7.04426707928e-06 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Signaling by NOTCH1 |
| GO:0000118 | 8.53456380768e-06 | 0.555555555556 | NCOR1 TBL1XR1 TBL1X SETD5 TBL1Y | histone deacetylase complex |
| REAC:R-HSA-381340 | 1.87298045635e-05 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-9006931 | 3.74129569128e-05 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-4839726 | 3.97328560982e-05 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Chromatin organization |
| REAC:R-HSA-3247509 | 3.97328560982e-05 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Chromatin modifying enzymes |
| CORUM:752 | 8.20609246787e-05 | 0.222222222222 | NCOR2 TBL1X | SMRT core complex |
| CORUM:1188 | 8.20609246787e-05 | 0.222222222222 | NCOR2 TBL1X | SMRT core complex |
| CORUM:7480 | 8.20609246787e-05 | 0.222222222222 | NCOR1 NCOR2 | HDAC3-H1.3-SMRT-N-Cor complex |
| REAC:R-HSA-9707616 | 0.000434042545956 | 0.333333333333 | NCOR1 TBL1X TBL1XR1 | Heme signaling |
| CORUM:1505 | 0.000573693030134 | 0.222222222222 | NCOR1 NCOR2 | NCOR2 complex |
| REAC:R-HSA-2151201 | 0.000652728146316 | 0.333333333333 | NCOR1 TBL1X TBL1XR1 | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-9711123 | 0.000676305290122 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Cellular response to chemical stress |
| REAC:R-HSA-157118 | 0.00104189526307 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Signaling by NOTCH |
| REAC:R-HSA-400253 | 0.00135277785859 | 0.333333333333 | NCOR1 TBL1X TBL1XR1 | Circadian Clock |
| GO:0003712 | 0.00203347484921 | 0.666666666667 | NCOR1 TBL1Y NCOR2 GPS2 TBL1XR1 TBL1X | transcription coregulator activity |
| REAC:R-HSA-9623433 | 0.00286935042585 | 0.222222222222 | NCOR1 NCOR2 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
| REAC:R-HSA-556833 | 0.00328763935443 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Metabolism of lipids |
| REAC:R-HSA-1592230 | 0.00381713777328 | 0.333333333333 | NCOR1 TBL1X TBL1XR1 | Mitochondrial biogenesis |
| KEGG:04310 | 0.00430102432376 | 0.333333333333 | TBL1XR1 TBL1Y TBL1X | Wnt signaling pathway |
| CORUM:5614 | 0.00465362752882 | 0.222222222222 | TBL1XR1 TBL1Y | Emerin complex 32 |
| REAC:R-HSA-9824446 | 0.00644900522555 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Viral Infection Pathways |
| REAC:R-HSA-1368082 | 0.00954313848115 | 0.222222222222 | TBL1XR1 TBL1X | RORA activates gene expression |
| REAC:R-HSA-5663202 | 0.0110276614435 | 0.444444444444 | NCOR1 TBL1X NCOR2 TBL1XR1 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-5663205 | 0.0174507834687 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Infectious disease |
| REAC:R-HSA-1368108 | 0.0200751738188 | 0.222222222222 | TBL1XR1 TBL1X | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| WP:WP61 | 0.0287089830042 | 0.222222222222 | NCOR1 NCOR2 | Notch signaling pathway |
| HPA:0490692 | 0.0289589517706 | 0.777777777778 | ANKRD11 NCOR1 NCOR2 GPS2 TBL1XR1 TBL1X SETD5 | smooth muscle; smooth muscle cells[>=Medium] |
| REAC:R-HSA-2173795 | 0.032153801025 | 0.222222222222 | NCOR1 NCOR2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| HPA:0270363 | 0.0389693299448 | 0.666666666667 | ANKRD11 NCOR1 SETD5 GPS2 TBL1XR1 TBL1X | kidney; cells in tubules[High] |
| REAC:R-HSA-383280 | 0.0392438573551 | 0.222222222222 | NCOR1 NCOR2 | Nuclear Receptor transcription pathway |
| REAC:R-HSA-212436 | 0.0395263988284 | 0.555555555556 | NCOR1 GPS2 NCOR2 TBL1X TBL1XR1 | Generic Transcription Pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCOR1 | GPS2 | 1.0 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NCOR2 | GPS2 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| TBL1XR1 | GPS2 | 1.0 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | TBL1X | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NCOR2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ANKRD11 | GPS2 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| GPS2 | TBL1Y | 0.999 |
mutually_exclusive (Q9BZK7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1X | TBL1Y | 0.999 |
mutually_exclusive (Q9BZK7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TBL1XR1 | TBL1Y | 0.998 |
mutually_exclusive (O60907)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR87 | GPS2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SETD5 | GPS2 | 0.986 | 0.132 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NCOR1 | TBL1XR1 | 0.969 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SETD5 | TBL1XR1 | 0.967 | 0.112 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_WMM youn_WMM hein () |
| NCOR2 | TBL1X | 0.955 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ANKRD11 | TBL1X | 0.954 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCOR1 | TBL1X | 0.95 | 0.154 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCOR2 | ANKRD11 | 0.92 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TBL1XR1 | ANKRD11 | 0.913 | 0.134 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TBL1XR1 | TBL1X | 0.91 | 0.954 |
mutually_exclusive (Q9BQ87)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WDR87 | ANKRD11 | 0.908 | bioplex3_WMM WMM_only | ||
| TBL1XR1 | NCOR2 | 0.89 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| WDR87 | NCOR2 | 0.89 | bioplex3_WMM WMM_only | ||
| SETD5 | NCOR2 | 0.89 | 0.296333333333 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| SETD5 | ANKRD11 | 0.885 | 0.16 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| NCOR1 | ANKRD11 | 0.885 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SETD5 | NCOR1 | 0.862 | 0.209 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| SETD5 | WDR87 | 0.768 | bioplex3_WMM WMM_only | ||
| WDR87 | TBL1X | 0.715 | bioplex3_WMM WMM_only | ||
| NCOR1 | NCOR2 | 0.676 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| WDR87 | NCOR1 | 0.675 | bioplex3_WMM WMM_only | ||
| WDR87 | TBL1XR1 | 0.654 | bioplex3_WMM WMM_only | ||
| SETD5 | TBL1X | 0.258 | 0.046 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes