hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07696.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COX6C | Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) | 5 | UniProt NCBI |
| COX7C | Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc) | 5 | UniProt NCBI |
| MT-CO1 | Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6442 | 0.000112778275641 | 1.0 | COX6C MT-CO1 | Cytochrome c oxidase, mitochondrial |
| WP:WP4922 | 0.000211115961056 | 1.0 | COX6C MT-CO1 | Mitochondrial complex IV assembly |
| KEGG:04260 | 0.000415528139074 | 1.0 | COX6C MT-CO1 | Cardiac muscle contraction |
| KEGG:00190 | 0.00119992691491 | 1.0 | COX6C MT-CO1 | Oxidative phosphorylation |
| KEGG:04932 | 0.00155920593969 | 1.0 | COX6C MT-CO1 | Non-alcoholic fatty liver disease |
| WP:WP5380 | 0.00194090480325 | 1.0 | COX6C MT-CO1 | 5q35 copy number variation |
| WP:WP111 | 0.00202305274778 | 1.0 | COX6C MT-CO1 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:05415 | 0.00267768543767 | 1.0 | COX6C MT-CO1 | Diabetic cardiomyopathy |
| REAC:R-HSA-9707564 | 0.00292369135789 | 1.0 | COX6C MT-CO1 | Cytoprotection by HMOX1 |
| KEGG:05208 | 0.0033003273675 | 1.0 | COX6C MT-CO1 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.00339933231144 | 1.0 | COX6C MT-CO1 | Thermogenesis |
| WP:WP4396 | 0.00396523446209 | 1.0 | COX6C MT-CO1 | Nonalcoholic fatty liver disease |
| KEGG:05012 | 0.00458495309323 | 1.0 | COX6C MT-CO1 | Parkinson disease |
| KEGG:05020 | 0.00485920816781 | 1.0 | COX6C MT-CO1 | Prion disease |
| REAC:R-HSA-5628897 | 0.00526469495831 | 1.0 | COX6C MT-CO1 | TP53 Regulates Metabolic Genes |
| KEGG:05016 | 0.00594761227231 | 1.0 | COX6C MT-CO1 | Huntington disease |
| REAC:R-HSA-611105 | 0.00828920325958 | 1.0 | COX6C MT-CO1 | Respiratory electron transport |
| KEGG:05014 | 0.00850662183301 | 1.0 | COX6C MT-CO1 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.0093688914925 | 1.0 | COX6C MT-CO1 | Alzheimer disease |
| REAC:R-HSA-163200 | 0.0124056103205 | 1.0 | COX6C MT-CO1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05022 | 0.0138982457502 | 1.0 | COX6C MT-CO1 | Pathways of neurodegeneration - multiple diseases |
| HPA:0271111 | 0.0185811895029 | 1.0 | COX6C MT-CO1 | kidney; bowman's capsule[>=Low] |
| HPA:0271143 | 0.019796826334 | 1.0 | COX6C MT-CO1 | kidney; proximal tubules (cell body)[High] |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | COX6C MT-CO1 | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:0271133 | 0.0245263757673 | 1.0 | COX6C MT-CO1 | kidney; distal tubules[High] |
| REAC:R-HSA-9711123 | 0.0284560094582 | 1.0 | COX6C MT-CO1 | Cellular response to chemical stress |
| WP:WP1995 | 0.0373151717536 | 0.5 | MT-CO1 | Effects of nitric oxide |
| CORUM:6410 | 0.0499419797295 | 0.5 | MT-CO1 | MITRAC7-COX1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MT-CO1 | COX6C | 0.967 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| COX6C | COX7C | 0.96 | 0.924 | bioplex3_HEK293 boldt boldt_WMM WMM_only |
| MT-CO1 | COX7C | 0.474 | 0.88 | bioplex3_HEK293 boldt_WMM WMM_only |
Related Complexes