hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07701.1
Complex Portal: CPX-14765
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CIR1 | Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) | 5 | UniProt NCBI |
| GDPD1 | Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1) | 5 | UniProt NCBI |
| ORM2 | Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2) | 5 | UniProt NCBI |
| UBE2U | Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) | 5 | UniProt NCBI |
| APCS | Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)] | 5 | UniProt NCBI |
| SAA2 | Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)] | 5 | UniProt NCBI |
| AGT | Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] | 5 | UniProt NCBI |
| APOC3 | Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) | 5 | UniProt NCBI |
| F2 | Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | 5 | UniProt NCBI |
| KNG1 | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | 5 | UniProt NCBI |
| MATN2 | Matrilin-2 | 5 | UniProt NCBI |
| P2RX6 | P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) | 5 | UniProt NCBI |
| CFB | Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment] | 5 | UniProt NCBI |
| SERPINB7 | Serpin B7 (Megsin) (TP55) | 4 | UniProt NCBI |
| C4BPA | C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) | 5 | UniProt NCBI |
| ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) | 5 | UniProt NCBI |
| SAA4 | Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA) | 4 | UniProt NCBI |
| ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP) | 5 | UniProt NCBI |
| A2M | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) | 5 | UniProt NCBI |
| PLG | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] | 5 | UniProt NCBI |
| GPX3 | Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) | 5 | UniProt NCBI |
| PHF11 | PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072562 | 9.93171861631e-11 | 0.473684210526 | KNG1 F2 ITIH2 APCS AGT PLG CFB C4BPA A2M | blood microparticle |
| KEGG:04610 | 1.59174917317e-08 | 0.315789473684 | KNG1 CFB PLG C4BPA F2 A2M | Complement and coagulation cascades |
| GO:0062023 | 2.28176873672e-06 | 0.473684210526 | KNG1 ITIH2 APCS AGT APOC3 PLG MATN2 F2 A2M | collagen-containing extracellular matrix |
| GO:0030312 | 1.39832951796e-05 | 0.473684210526 | KNG1 ITIH2 APCS AGT APOC3 PLG MATN2 F2 A2M | external encapsulating structure |
| GO:0031012 | 1.39832951796e-05 | 0.473684210526 | KNG1 ITIH2 APCS AGT APOC3 PLG MATN2 F2 A2M | extracellular matrix |
| WP:WP1533 | 2.77304132123e-05 | 0.210526315789 | SAA2 SAA4 PLG F2 | Vitamin B12 metabolism |
| WP:WP558 | 4.40082097124e-05 | 0.210526315789 | F2 CFB PLG KNG1 | Complement and coagulation cascades |
| WP:WP176 | 8.35970265871e-05 | 0.210526315789 | SAA2 SAA4 PLG F2 | Folate metabolism |
| KEGG:04080 | 0.000190210089767 | 0.263157894737 | F2 P2RX6 AGT PLG KNG1 | Neuroactive ligand-receptor interaction |
| WP:WP15 | 0.000197492861567 | 0.210526315789 | SAA2 SAA4 PLG F2 | Selenium micronutrient network |
| WP:WP2806 | 0.000325755156672 | 0.210526315789 | APCS PLG C4BPA CFB | Complement system |
| REAC:R-HSA-140837 | 0.000626989662445 | 0.157894736842 | F2 A2M KNG1 | Intrinsic Pathway of Fibrin Clot Formation |
| REAC:R-HSA-381426 | 0.0022128952312 | 0.210526315789 | F2 PLG ITIH2 KNG1 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| REAC:R-HSA-140877 | 0.00244996771924 | 0.157894736842 | F2 A2M KNG1 | Formation of Fibrin Clot (Clotting Cascade) |
| WP:WP4927 | 0.00300053589263 | 0.105263157895 | F2 PLG | COVID 19 thrombosis and anticoagulation |
| REAC:R-HSA-977606 | 0.00576261803979 | 0.157894736842 | F2 C4BPA CFB | Regulation of Complement cascade |
| GO:0004866 | 0.0076801505985 | 0.263157894737 | A2M KNG1 AGT ITIH2 SERPINB7 | endopeptidase inhibitor activity |
| GO:0030414 | 0.00889535012757 | 0.263157894737 | A2M KNG1 AGT ITIH2 SERPINB7 | peptidase inhibitor activity |
| REAC:R-HSA-166658 | 0.00929631212096 | 0.157894736842 | F2 C4BPA CFB | Complement cascade |
| WP:WP554 | 0.0131410594154 | 0.105263157895 | KNG1 AGT | ACE inhibitor pathway |
| GO:0061135 | 0.0134795576303 | 0.263157894737 | A2M KNG1 AGT ITIH2 SERPINB7 | endopeptidase regulator activity |
| GO:0061045 | 0.0245207896697 | 0.210526315789 | APCS KNG1 PLG F2 | negative regulation of wound healing |
| HP:0031244 | 0.0266047515813 | 0.105263157895 | KNG1 PLG | Swollen lip |
| WP:WP272 | 0.0303219626721 | 0.105263157895 | F2 PLG | Blood clotting cascade |
| GO:0004857 | 0.0341851223867 | 0.315789473684 | KNG1 AGT APOC3 SERPINB7 ITIH2 A2M | enzyme inhibitor activity |
| GO:0061134 | 0.0405921692043 | 0.263157894737 | A2M KNG1 AGT ITIH2 SERPINB7 | peptidase regulator activity |
| REAC:R-HSA-76002 | 0.0460471436812 | 0.210526315789 | F2 A2M PLG KNG1 | Platelet activation, signaling and aggregation |
| CORUM:6103 | 0.0496196263904 | 0.0526315789474 | AGT | proMBP-angiotensinogen complex |
| WP:WP4969 | 0.0499462656714 | 0.105263157895 | KNG1 AGT | RAS and bradykinin pathways in COVID 19 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| UBE2U | SAA4 | 0.999 | ||
| F2 | P2RX6 | 0.998 | ||
| PHF11 | GPX3 | 0.997 | ||
| UBE2U | SAA2 | 0.997 | ||
| ITIH1 | PHF11 | 0.997 | ||
| UBE2U | ITIH1 | 0.997 | ||
| C4BPA | PHF11 | 0.997 | ||
| GPX3 | A2M | 0.997 | 0.37 | |
| F2 | UBE2U | 0.997 | ||
| PHF11 | APCS | 0.996 | ||
| APOC3 | UBE2U | 0.995 | ||
| UBE2U | CFB | 0.995 | ||
| UBE2U | AGT | 0.995 | ||
| UBE2U | KNG1 | 0.994 | ||
| KNG1 | PHF11 | 0.994 | ||
| UBE2U | APCS | 0.993 | ||
| PHF11 | AGT | 0.993 | ||
| MATN2 | APCS | 0.992 | 0.09 | |
| UBE2U | C4BPA | 0.991 | ||
| P2RX6 | ITIH2 | 0.991 |
structurally_consistent (dimer)
|
|
| ORM2 | PHF11 | 0.991 | ||
| UBE2U | ORM2 | 0.991 | ||
| PHF11 | CFB | 0.991 | ||
| MATN2 | CFB | 0.989 | 0.218 | |
| P2RX6 | ORM2 | 0.988 |
structurally_consistent (dimer)
|
|
| UBE2U | PLG | 0.986 | ||
| PHF11 | PLG | 0.983 | ||
| ITIH1 | MATN2 | 0.982 | 0.08 | |
| CIR1 | AGT | 0.98 | 0.098 | |
| UBE2U | ITIH2 | 0.978 | ||
| ITIH2 | PHF11 | 0.978 | ||
| ORM2 | A2M | 0.977 | 0.726 |
structurally_consistent (O15547)
|
| MATN2 | PLG | 0.977 | 0.168 | |
| APOC3 | MATN2 | 0.974 | 0.216 | |
| MATN2 | ORM2 | 0.974 | 0.104 | |
| ORM2 | ITIH2 | 0.973 | 0.308 |
structurally_consistent (O15547)
|
| KNG1 | A2M | 0.973 | ||
| ORM2 | KNG1 | 0.972 | ||
| PHF11 | A2M | 0.972 | ||
| UBE2U | A2M | 0.972 | ||
| A2M | GDPD1 | 0.967 | 0.174 | |
| P2RX6 | PLG | 0.966 |
structurally_consistent (dimer)
|
|
| PHF11 | SERPINB7 | 0.962 | ||
| P2RX6 | A2M | 0.959 |
structurally_consistent (dimer)
|
|
| KNG1 | ITIH2 | 0.951 | ||
| APOC3 | ITIH2 | 0.949 | 0.224 | |
| MATN2 | A2M | 0.946 | 0.15 | |
| MATN2 | ITIH2 | 0.939 | 0.14 | |
| ITIH2 | GDPD1 | 0.923 | 0.098 | |
| APOC3 | GDPD1 | 0.918 | 0.166 |
structurally_consistent (dimer)
|
| ITIH1 | APCS | 0.905 | 0.404 | |
| SAA2 | SAA4 | 0.902 | ||
| CIR1 | A2M | 0.884 | 0.154 | |
| KNG1 | CFB | 0.882 | ||
| C4BPA | A2M | 0.87 | 0.19 | |
| ORM2 | CFB | 0.867 | 0.716 | |
| CFB | GDPD1 | 0.862 | 0.068 | |
| ITIH1 | PLG | 0.851 | 0.56 | |
| A2M | CFB | 0.831 | 0.248 | |
| APOC3 | CFB | 0.829 | 0.34 | |
| APOC3 | ORM2 | 0.829 | 0.688 |
structurally_consistent (Q8N9F7)
|
| ORM2 | C4BPA | 0.828 | 0.4 | |
| ITIH1 | C4BPA | 0.828 | 0.272 | |
| PLG | APCS | 0.817 | 0.398 | |
| ORM2 | APCS | 0.816 | 0.746 | |
| APOC3 | A2M | 0.811 | 0.45 | |
| F2 | SERPINB7 | 0.807 | 0.086 | |
| ITIH2 | CFB | 0.782 | 0.236 | |
| C4BPA | APCS | 0.77 | 0.23 |
structurally_consistent (dimer)
|
| C4BPA | PLG | 0.766 | 0.346 | |
| ITIH2 | C4BPA | 0.763 | 0.248 | |
| F2 | PLG | 0.753 | 0.436 | |
| ITIH1 | ORM2 | 0.746 | 0.494 | |
| ORM2 | GDPD1 | 0.746 | 0.16 |
mixed_interface
|
| CFB | APCS | 0.746 | 0.408 | |
| ITIH1 | CFB | 0.744 | 0.506 | |
| F2 | A2M | 0.718 | 0.186 | |
| A2M | APCS | 0.69 | 0.387333333333 | |
| F2 | SAA4 | 0.688 | ||
| A2M | PLG | 0.676 | 0.234 | |
| APOC3 | SAA4 | 0.656 | ||
| APOC3 | APCS | 0.649 | 0.38 | |
| APOC3 | ITIH1 | 0.649 | 0.338 | |
| ITIH1 | A2M | 0.642 | 0.524 | |
| ORM2 | PLG | 0.638 | 0.538 |
structurally_consistent (O15547)
|
| ITIH1 | ITIH2 | 0.636 | 0.244 | |
| GPX3 | AGT | 0.634 | 0.244 | |
| F2 | GPX3 | 0.634 | 0.41 | |
| SAA4 | ITIH2 | 0.634 | ||
| SAA4 | KNG1 | 0.633 | ||
| SAA4 | CFB | 0.633 | ||
| SAA4 | AGT | 0.633 | ||
| SAA4 | C4BPA | 0.633 | ||
| SAA4 | A2M | 0.633 | ||
| SAA4 | ITIH1 | 0.633 | ||
| SAA4 | ORM2 | 0.633 | ||
| KNG1 | GDPD1 | 0.627 | ||
| PLG | SERPINB7 | 0.625 | 0.1 | |
| PLG | CFB | 0.621 | 0.338 | |
| C4BPA | CFB | 0.613 | 0.186 | |
| ITIH2 | APCS | 0.599 | 0.2 | |
| APOC3 | PLG | 0.598 | 0.436 | |
| AGT | SERPINB7 | 0.587 | 0.096 | |
| APOC3 | KNG1 | 0.567 | ||
| ITIH2 | PLG | 0.558 | 0.35 | |
| KNG1 | C4BPA | 0.532 | ||
| ITIH2 | A2M | 0.507 | 0.446 | |
| ITIH1 | KNG1 | 0.497 | ||
| KNG1 | APCS | 0.497 | ||
| AGT | A2M | 0.481 | 0.29 | |
| APOC3 | SAA2 | 0.474 | ||
| F2 | SAA2 | 0.468 | ||
| SAA2 | AGT | 0.468 | ||
| KNG1 | AGT | 0.455 | ||
| SAA4 | APCS | 0.445 | ||
| SERPINB7 | CFB | 0.443 | 0.076 | |
| A2M | SERPINB7 | 0.439 | 0.126 | |
| ITIH1 | AGT | 0.438 | 0.294 | |
| GPX3 | APCS | 0.438 | ||
| C4BPA | GPX3 | 0.438 | 0.18 | |
| ITIH1 | GPX3 | 0.438 | 0.22 | |
| C4BPA | AGT | 0.438 | 0.336 | |
| SERPINB7 | APCS | 0.43 | ||
| SAA2 | C4BPA | 0.418 | ||
| SAA2 | ITIH1 | 0.418 | ||
| KNG1 | GPX3 | 0.404 | ||
| ORM2 | GPX3 | 0.404 | 0.39 | |
| AGT | APCS | 0.404 | 0.262 | |
| KNG1 | SERPINB7 | 0.397 | ||
| SAA2 | APCS | 0.396 | ||
| F2 | KNG1 | 0.384 | ||
| GPX3 | CFB | 0.384 | 0.24 | |
| F2 | CFB | 0.384 | 0.326 | |
| F2 | ITIH1 | 0.384 | 0.53 | |
| F2 | APCS | 0.384 | 0.436528409091 | |
| F2 | C4BPA | 0.384 | 0.32 | |
| SAA2 | CFB | 0.378 | ||
| KNG1 | PLG | 0.364 | ||
| F2 | ORM2 | 0.362 | 0.682 | |
| GPX3 | PLG | 0.362 | 0.178 | |
| ORM2 | AGT | 0.362 | 0.394 | |
| AGT | CFB | 0.355 | 0.32 | |
| ITIH2 | GPX3 | 0.346 | 0.168 | |
| ITIH2 | AGT | 0.346 | 0.294529411765 | |
| F2 | ITIH2 | 0.346 | 0.272 | |
| F2 | APOC3 | 0.335 | 0.6 | |
| APOC3 | AGT | 0.314 | 0.438 | |
| APOC3 | C4BPA | 0.314 | 0.328 | |
| AGT | PLG | 0.294 | 0.26 | |
| GPX3 | SERPINB7 | 0.274 | 0.06 | |
| C4BPA | SERPINB7 | 0.274 | 0.036 | |
| ITIH1 | SERPINB7 | 0.274 | 0.066 | |
| SAA2 | KNG1 | 0.255 | ||
| ITIH2 | SERPINB7 | 0.254 | 0.038 | |
| ORM2 | SERPINB7 | 0.23 | 0.09 | |
| F2 | AGT | 0.22 | 0.374 | |
| SAA2 | ORM2 | 0.22 | ||
| SAA4 | PLG | 0.22 | ||
| SAA2 | PLG | 0.22 | ||
| SAA2 | A2M | 0.21 | ||
| SAA2 | ITIH2 | 0.157 | ||
| CIR1 | PLG | 0.037 | 0.082 | |
| APOC3 | SERPINB7 | 0.007 | 0.17 |
Related Complexes