hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07705.1
Complex Portal: CPX-21764
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP43 | Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) | 5 | UniProt NCBI |
| NUP133 | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | 5 | UniProt NCBI |
| SEC13 | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | 5 | UniProt NCBI |
| AAAS | Aladin (Adracalin) | 5 | UniProt NCBI |
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | 5 | UniProt NCBI |
| NUP37 | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | 5 | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 5 | UniProt NCBI |
| NUP107 | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:87 | 3.72694642565e-21 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | Nup 107-160 subcomplex |
| GO:0031080 | 7.65174645029e-18 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | nuclear pore outer ring |
| WP:WP3998 | 6.25719766149e-16 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | Prader Willi and Angelman syndrome |
| KEGG:03013 | 1.77447585397e-15 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | Nucleocytoplasmic transport |
| GO:0005643 | 3.4289443185e-13 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | nuclear pore |
| REAC:R-HSA-170822 | 5.52472986443e-13 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 5.52472986443e-13 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168271 | 6.9647360974e-13 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 6.9647360974e-13 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168333 | 6.9647360974e-13 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-180746 | 1.07915359371e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 1.07915359371e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 1.07915359371e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-4085377 | 1.32795492585e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 1.32795492585e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 1.32795492585e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 1.62276991723e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 1.97015895866e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 1.97015895866e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 2.37735886493e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 3.40379085006e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 4.04128893235e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 4.77522655503e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 5.61692290931e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 7.67375392499e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 8.9165735268e-12 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 1.56935198351e-11 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 2.63031880849e-11 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | snRNP Assembly |
| REAC:R-HSA-194441 | 2.63031880849e-11 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 4.23101383174e-11 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | tRNA processing in the nucleus |
| GO:0005635 | 1.20145542174e-10 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | nuclear envelope |
| REAC:R-HSA-70171 | 1.20339569165e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Glycolysis |
| REAC:R-HSA-3371453 | 1.20339569165e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-1169408 | 1.32350148587e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 1.32350148587e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-2995410 | 1.45342522155e-10 | 0.666666666667 | SEC13 NUP37 NUP107 SPAST NUP133 NUP43 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-159236 | 1.90856243268e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-5619102 | 1.90856243268e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 2.0843691528e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 2.27345555282e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-9615933 | 2.27556107573e-10 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-72202 | 4.03967603927e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-70326 | 4.03967603927e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Glucose metabolism |
| REAC:R-HSA-3371556 | 6.34939070671e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 9.66674725414e-10 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 1.62273319069e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | tRNA processing |
| REAC:R-HSA-9610379 | 1.62273319069e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | HCMV Late Events |
| GO:0006913 | 2.23445781167e-09 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | nucleocytoplasmic transport |
| GO:0051169 | 2.23445781167e-09 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | nuclear transport |
| REAC:R-HSA-9705671 | 3.45668440709e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05014 | 4.32449730251e-09 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-211000 | 4.75595232495e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 5.27021742229e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | HCMV Early Events |
| REAC:R-HSA-68875 | 5.82993903981e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Mitotic Prophase |
| REAC:R-HSA-162909 | 6.76168795948e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 8.58883605176e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 8.99950471828e-09 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Influenza Viral RNA Transcription and Replication |
| GO:0000776 | 9.65850684075e-09 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | kinetochore |
| GO:0000779 | 1.18614999938e-08 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | condensed chromosome, centromeric region |
| REAC:R-HSA-5619115 | 1.40851157879e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Disorders of transmembrane transporters |
| REAC:R-HSA-162587 | 1.47039095704e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 1.47039095704e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | HCMV Infection |
| REAC:R-HSA-168255 | 1.89111968986e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Influenza Infection |
| REAC:R-HSA-3108232 | 2.81303360613e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 3.39834006151e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SUMOylation |
| REAC:R-HSA-913531 | 5.22691179169e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Interferon Signaling |
| CORUM:1347 | 5.24129669272e-08 | 0.333333333333 | NUP133 NUP107 NUP98 | NPC subcomplex (NUP98, NUP107, NUP133, NUP160) |
| REAC:R-HSA-68886 | 7.0518656916e-08 | 0.777777777778 | NUP133 SEC13 NUP37 NUP107 SPAST AAAS NUP43 | M Phase |
| REAC:R-HSA-9705683 | 8.06468880307e-08 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SARS-CoV-2-host interactions |
| GO:0000775 | 1.23354261827e-07 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | chromosome, centromeric region |
| GO:0000793 | 1.63763500985e-07 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | condensed chromosome |
| REAC:R-HSA-162906 | 2.14147193465e-07 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | HIV Infection |
| REAC:R-HSA-68882 | 2.26100730541e-07 | 0.666666666667 | SEC13 NUP37 NUP107 SPAST NUP133 NUP43 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 2.32282288794e-07 | 0.666666666667 | SEC13 NUP37 NUP107 SPAST NUP133 NUP43 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-141444 | 2.59217745739e-07 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 2.59217745739e-07 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Amplification of signal from the kinetochores |
| REAC:R-HSA-71387 | 5.1901617931e-07 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Metabolism of carbohydrates |
| REAC:R-HSA-69618 | 5.85413794188e-07 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-69278 | 6.02680958754e-07 | 0.777777777778 | NUP133 SEC13 NUP37 NUP107 SPAST AAAS NUP43 | Cell Cycle, Mitotic |
| REAC:R-HSA-9648025 | 7.36321241731e-07 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | EML4 and NUDC in mitotic spindle formation |
| GO:0031975 | 7.62815078112e-07 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | envelope |
| GO:0031967 | 7.62815078112e-07 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | organelle envelope |
| REAC:R-HSA-9694516 | 7.63844869322e-07 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 7.80806320933e-07 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-2500257 | 1.04090893218e-06 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 1.61555801825e-06 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | RHO GTPases Activate Formins |
| REAC:R-HSA-1640170 | 2.5483919717e-06 | 0.777777777778 | NUP133 SEC13 NUP37 NUP107 SPAST AAAS NUP43 | Cell Cycle |
| GO:0046907 | 3.21203815684e-06 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | intracellular transport |
| GO:0098687 | 3.83415308232e-06 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | chromosomal region |
| GO:0006999 | 4.51189669214e-06 | 0.444444444444 | NUP133 SEH1L NUP107 NUP98 | nuclear pore organization |
| REAC:R-HSA-9679506 | 5.19699496686e-06 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | SARS-CoV Infections |
| REAC:R-HSA-2262752 | 5.51158942255e-06 | 0.777777777778 | NUP133 SEC13 NUP37 SEH1L NUP107 AAAS NUP43 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 5.89264343021e-06 | 0.777777777778 | NUP133 SEC13 NUP37 SEH1L NUP107 AAAS NUP43 | Cellular responses to stimuli |
| REAC:R-HSA-2467813 | 8.5867999114e-06 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 1.14859676503e-05 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Mitotic Prometaphase |
| GO:0051649 | 3.04960371317e-05 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | establishment of localization in cell |
| REAC:R-HSA-69620 | 6.8609480026e-05 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | Cell Cycle Checkpoints |
| REAC:R-HSA-1280215 | 9.13476977151e-05 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Cytokine Signaling in Immune system |
| REAC:R-HSA-195258 | 9.20482128285e-05 | 0.555555555556 | NUP43 NUP37 SEC13 NUP107 NUP133 | RHO GTPase Effectors |
| REAC:R-HSA-194315 | 0.000111617729477 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Signaling by Rho GTPases |
| GO:0006997 | 0.000117830712316 | 0.555555555556 | SEH1L NUP133 SPAST NUP107 NUP98 | nucleus organization |
| REAC:R-HSA-9716542 | 0.00012709299758 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-8953854 | 0.000181368858283 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Metabolism of RNA |
| REAC:R-HSA-9824446 | 0.000213160163792 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Viral Infection Pathways |
| CORUM:6216 | 0.000273361732609 | 0.222222222222 | SEC13 SEH1L | GATOR2 complex |
| GO:0000972 | 0.000282244947588 | 0.333333333333 | NUP133 NUP107 NUP98 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| HP:0031504 | 0.000295209923159 | 0.333333333333 | NUP133 NUP107 NUP37 | Foamy urine |
| GO:0140513 | 0.000441206708996 | 0.888888888889 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 AAAS NUP43 | nuclear protein-containing complex |
| HP:0012579 | 0.000532132295745 | 0.333333333333 | NUP133 NUP107 NUP37 | Minimal change glomerulonephritis |
| REAC:R-HSA-5663205 | 0.000716014897471 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Infectious disease |
| CORUM:6217 | 0.000764679747525 | 0.222222222222 | SEC13 SEH1L | GATOR complex |
| CORUM:6753 | 0.000764679747525 | 0.222222222222 | SEC13 SEH1L | SOG complex |
| HP:0001967 | 0.000870108028777 | 0.333333333333 | NUP133 NUP107 NUP37 | Diffuse mesangial sclerosis |
| HP:0002586 | 0.000951387260424 | 0.333333333333 | NUP133 NUP107 NUP37 | Peritonitis |
| HP:0001966 | 0.00154668305334 | 0.333333333333 | NUP133 NUP107 NUP37 | Abnormal glomerular mesangium morphology |
| HP:0033072 | 0.00219910586189 | 0.333333333333 | NUP133 NUP107 NUP37 | Abnormal macroscopic urine appearance |
| GO:0031965 | 0.0030375570634 | 0.555555555556 | NUP133 NUP98 SPAST NUP107 AAAS | nuclear membrane |
| HP:0002585 | 0.00358446411683 | 0.333333333333 | NUP133 NUP107 NUP37 | Abnormal peritoneum morphology |
| HP:0000097 | 0.00379009050824 | 0.333333333333 | NUP133 NUP107 NUP37 | Focal segmental glomerulosclerosis |
| GO:0051641 | 0.00405212523334 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | cellular localization |
| GO:0099080 | 0.00425836613708 | 0.777777777778 | SEC13 NUP98 NUP37 SEH1L NUP107 NUP133 NUP43 | supramolecular complex |
| REAC:R-HSA-597592 | 0.00564787922656 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Post-translational protein modification |
| HP:0003676 | 0.00736702565334 | 0.444444444444 | NUP133 SPAST NUP107 AAAS | Progressive |
| REAC:R-HSA-74160 | 0.00759942737987 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Gene expression (Transcription) |
| HP:0000099 | 0.00969509588682 | 0.333333333333 | NUP133 NUP107 NUP37 | Glomerulonephritis |
| HP:0045073 | 0.0100904083719 | 0.333333333333 | NUP133 NUP107 NUP37 | Serositis |
| HP:0000096 | 0.0122273883855 | 0.333333333333 | NUP133 NUP107 NUP37 | Glomerular sclerosis |
| GO:0017056 | 0.0123615112794 | 0.333333333333 | NUP133 NUP107 NUP98 | structural constituent of nuclear pore |
| GO:0006606 | 0.0148319287105 | 0.444444444444 | NUP133 NUP98 NUP107 SEC13 | protein import into nucleus |
| GO:0006810 | 0.0155634227783 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | transport |
| REAC:R-HSA-1643685 | 0.0165408171212 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Disease |
| GO:0051170 | 0.0179204158456 | 0.444444444444 | NUP133 NUP98 NUP107 SEC13 | import into nucleus |
| HP:0100539 | 0.0185282317385 | 0.333333333333 | NUP133 NUP107 NUP37 | Periorbital edema |
| HP:0100720 | 0.0201617678902 | 0.222222222222 | NUP133 NUP107 | Hypoplasia of the ear cartilage |
| HP:0003073 | 0.0210257565099 | 0.333333333333 | NUP133 NUP107 NUP37 | Hypoalbuminemia |
| HP:0012116 | 0.0210257565099 | 0.333333333333 | NUP133 NUP107 NUP37 | Abnormal circulating albumin concentration |
| HP:0000123 | 0.022353712526 | 0.333333333333 | NUP133 NUP107 NUP37 | Nephritis |
| HP:0000282 | 0.030653711276 | 0.333333333333 | NUP133 NUP107 NUP37 | Facial edema |
| REAC:R-HSA-168256 | 0.0342353908338 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Immune System |
| GO:0051234 | 0.0353624737849 | 1.0 | NUP133 SEC13 NUP98 NUP37 SEH1L NUP107 SPAST AAAS NUP43 | establishment of localization |
| HP:0003774 | 0.0359331417291 | 0.333333333333 | NUP133 NUP107 NUP37 | Stage 5 chronic kidney disease |
| REAC:R-HSA-392499 | 0.0367270844403 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Metabolism of proteins |
| REAC:R-HSA-1430728 | 0.0452440709483 | 0.666666666667 | NUP133 SEC13 NUP37 NUP107 AAAS NUP43 | Metabolism |
| HP:0032599 | 0.0466491465176 | 0.222222222222 | NUP133 NUP107 | Abnormal renal tubular epithelial morphology |
| HP:0000092 | 0.0466491465176 | 0.222222222222 | NUP133 NUP107 | Renal tubular atrophy |
| HP:0003679 | 0.0484060075333 | 0.444444444444 | NUP133 SPAST NUP107 AAAS | Pace of progression |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NUP133 | NUP107 | 1.0 | 0.962 |
structurally_consistent (P55735)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| NUP43 | NUP133 | 0.999 | 0.804 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NUP43 | NUP37 | 0.999 | 0.942 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NUP43 | NUP107 | 0.999 | 0.818 |
structurally_consistent (Q8WUM0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SEH1L | NUP133 | 0.999 | 0.78 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| NUP98 | NUP43 | 0.999 | 0.84 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SEH1L | NUP43 | 0.999 | 0.938 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| NUP133 | NUP37 | 0.999 | 0.806 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUP37 | NUP107 | 0.999 | 0.822 | hein_WMM bioplex_WMM Guru bioplex3_WMM hein () Malo fraction | |
| SEC13 | NUP133 | 0.999 | 0.472 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| SEC13 | NUP43 | 0.999 | 0.286 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NUP98 | NUP133 | 0.999 | 0.946 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| SEC13 | SEH1L | 0.997 | 0.172 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| SEC13 | NUP107 | 0.997 | 0.448 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| SEH1L | NUP37 | 0.997 | 0.83 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| SEC13 | NUP37 | 0.996 | 0.248 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| NUP98 | SPAST | 0.996 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NUP43 | SPAST | 0.995 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SEH1L | NUP107 | 0.995 | 0.802 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| SEC13 | AAAS | 0.993 | 0.118 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SEC13 | NUP98 | 0.993 | 0.168 |
structurally_consistent (P57740)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| SPAST | NUP107 | 0.992 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NUP98 | SEH1L | 0.989 | 0.85 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () fraction |
| NUP98 | NUP37 | 0.987 | 0.78 |
structurally_consistent (Q12769)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () fraction |
| NUP98 | NUP107 | 0.987 | 0.966 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM |
| SEH1L | AAAS | 0.983 | 0.176 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| NUP37 | SPAST | 0.979 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| AAAS | NUP37 | 0.975 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NUP133 | SPAST | 0.969 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| AAAS | NUP107 | 0.957 | 0.382 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NUP43 | AAAS | 0.759 | 0.41 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SEC13 | SPAST | 0.683 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| NUP98 | AAAS | 0.642 | 0.578 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NUP133 | AAAS | 0.329 | 0.484 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| AAAS | SPAST | 0.009 | 0.044 | bioplex_WMM WMM_only | |
| SEH1L | SPAST | 0.006 | 0.062 |
mutually_exclusive (Q8NFH3)
|
bioplex3_HEK293 bioplex () |
Related Complexes