hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07707.1
Complex Portal: CPX-17534
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | 5 | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | 5 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP438 | 1.53229326573e-05 | 1.0 | LIG4 WRN | Non homologous end joining |
| HP:0000320 | 0.000464783196579 | 1.0 | LIG4 WRN | Bird-like facies |
| WP:WP4946 | 0.00269343105153 | 1.0 | LIG4 WRN | DNA repair pathways full network |
| HP:0100585 | 0.00825331926278 | 1.0 | LIG4 WRN | Telangiectasia of the skin |
| HP:0000444 | 0.0105293899166 | 1.0 | LIG4 WRN | Convex nasal ridge |
| HP:0200055 | 0.0136871816346 | 1.0 | LIG4 WRN | Small hand |
| HP:0000275 | 0.0162434892157 | 1.0 | LIG4 WRN | Narrow face |
| REAC:R-HSA-5693532 | 0.0211937720117 | 1.0 | LIG4 WRN | DNA Double-Strand Break Repair |
| CORUM:213 | 0.0249718442457 | 0.5 | LIG4 | DNA ligase IV-XRCC1 complex |
| CORUM:4082 | 0.0249718442457 | 0.5 | WRN | XRCC6-XRCC5-WRN complex |
| HP:0002209 | 0.0260620342435 | 1.0 | LIG4 WRN | Sparse scalp hair |
| HP:0000274 | 0.0260620342435 | 1.0 | LIG4 WRN | Small face |
| KEGG:03450 | 0.0261247873322 | 0.5 | LIG4 | Non-homologous end-joining |
| HP:0001009 | 0.0351868219998 | 1.0 | LIG4 WRN | Telangiectasia |
| HP:0000141 | 0.0371758206793 | 1.0 | LIG4 WRN | Amenorrhea |
| HP:0011772 | 0.0392194997349 | 1.0 | LIG4 WRN | Abnormal thyroid morphology |
| CORUM:1217 | 0.0499419797295 | 0.5 | WRN | WRN-TRF2 complex |
| CORUM:359 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4-XLF complex |
| CORUM:354 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:348 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:344 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:206 | 0.0499419797295 | 0.5 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:5235 | 0.0499419797295 | 0.5 | WRN | WRN-Ku70-Ku80-PARP1 complex |
| CORUM:7282 | 0.0499419797295 | 0.5 | WRN | FEN1-WRN complex |
| HP:0012060 | 0.0499436884913 | 0.5 | WRN | Acral lentiginous melanoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| XRCC6 | XRCC5 | 1.0 | 0.96 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| WRN | XRCC6 | 0.999 | 0.32 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| LIG4 | XRCC6 | 0.982 | 0.418 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () boldt_WMM | |
| WRN | XRCC5 | 0.96 | 0.48 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| LIG4 | XRCC5 | 0.916 | 0.398 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| WRN | LIG4 | 0.432 | 0.118 | hein_WMM WMM_only boldt_WMM |
Related Complexes