hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07724.1
Complex Portal: CPX-18111
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | 5 | UniProt NCBI |
| SRSF12 | Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19) | 5 | UniProt NCBI |
| LUC7L2 | Putative RNA-binding protein Luc7-like 2 | 5 | UniProt NCBI |
| CLK2 | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | 5 | UniProt NCBI |
| CLK1 | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | 5 | UniProt NCBI |
| YTHDC1 | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008380 | 1.18473333407e-05 | 1.0 | CLK1 NCBP1 SRSF12 LUC7L2 YTHDC1 CLK2 | RNA splicing |
| GO:0043484 | 3.86526858608e-05 | 0.833333333333 | YTHDC1 SRSF12 CLK1 NCBP1 CLK2 | regulation of RNA splicing |
| GO:0000245 | 0.000338785167119 | 0.666666666667 | YTHDC1 SRSF12 NCBP1 LUC7L2 | spliceosomal complex assembly |
| WP:WP411 | 0.000799478520302 | 0.5 | CLK1 NCBP1 CLK2 | mRNA processing |
| GO:0006396 | 0.00102537166899 | 1.0 | CLK1 NCBP1 SRSF12 LUC7L2 YTHDC1 CLK2 | RNA processing |
| GO:0006376 | 0.00560226816097 | 0.5 | YTHDC1 SRSF12 LUC7L2 | mRNA splice site recognition |
| GO:0022618 | 0.0186767143264 | 0.666666666667 | YTHDC1 SRSF12 NCBP1 LUC7L2 | protein-RNA complex assembly |
| GO:0071826 | 0.022574051237 | 0.666666666667 | YTHDC1 SRSF12 NCBP1 LUC7L2 | protein-RNA complex organization |
| HPA:0570812 | 0.0387978353921 | 0.833333333333 | YTHDC1 LUC7L2 CLK1 NCBP1 CLK2 | testis; spermatogonia cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CLK2 | CLK1 | 0.999 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CLK2 | YTHDC1 | 0.997 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SRSF12 | LUC7L2 | 0.993 | 0.574 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| NCBP1 | YTHDC1 | 0.989 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRSF12 | CLK2 | 0.987 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| CLK2 | LUC7L2 | 0.977 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| NCBP1 | CLK2 | 0.954 | 0.102 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CLK1 | YTHDC1 | 0.946 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| SRSF12 | YTHDC1 | 0.906 | 0.734 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCBP1 | LUC7L2 | 0.767 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NCBP1 | CLK1 | 0.707 | 0.41 | bioplex_WMM bioplex3_WMM WMM_only | |
| SRSF12 | CLK1 | 0.696 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCBP1 | SRSF12 | 0.692 | 0.17 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CLK1 | LUC7L2 | 0.258 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only | |
| LUC7L2 | YTHDC1 | 0.19 | 0.212 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes