hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07727.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | 5 | UniProt NCBI |
| H2AJ | Histone H2A.J (H2a/j) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-68616 | 1.365277865e-05 | 1.0 | ORC6 ORC2 H2AJ | Assembly of the ORC complex at the origin of replication |
| CORUM:5251 | 2.05032700758e-05 | 0.666666666667 | ORC6 ORC2 | Ku-ORC complex |
| CORUM:1033 | 5.12534978153e-05 | 0.666666666667 | ORC6 ORC2 | ORC complex (origin recognition complex) |
| CORUM:1031 | 5.12534978153e-05 | 0.666666666667 | ORC6 ORC2 | ORC complex (origin recognition complex) |
| CORUM:389 | 5.12534978153e-05 | 0.666666666667 | ORC6 ORC2 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68867 | 0.000166931582017 | 1.0 | ORC6 ORC2 H2AJ | Assembly of the pre-replicative complex |
| REAC:R-HSA-68689 | 0.000190864539041 | 0.666666666667 | ORC6 ORC2 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-69002 | 0.000242010199538 | 1.0 | ORC6 ORC2 H2AJ | DNA Replication Pre-Initiation |
| REAC:R-HSA-113507 | 0.00024538606603 | 0.666666666667 | ORC6 ORC2 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-69306 | 0.000402642186048 | 1.0 | ORC6 ORC2 H2AJ | DNA Replication |
| WP:WP466 | 0.000973512535349 | 0.666666666667 | ORC6 ORC2 | DNA replication |
| REAC:R-HSA-113510 | 0.00157362645287 | 0.666666666667 | ORC6 ORC2 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.00227715198732 | 0.666666666667 | ORC6 ORC2 | G1 to S cell cycle control |
| REAC:R-HSA-68962 | 0.00359505378021 | 0.666666666667 | ORC6 ORC2 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00428896488724 | 0.666666666667 | ORC6 ORC2 | Activation of ATR in response to replication stress |
| WP:WP179 | 0.00751610583681 | 0.666666666667 | ORC6 ORC2 | Cell cycle |
| KEGG:04110 | 0.00858640718729 | 0.666666666667 | ORC6 ORC2 | Cell cycle |
| REAC:R-HSA-69278 | 0.0112530904983 | 1.0 | ORC6 ORC2 H2AJ | Cell Cycle, Mitotic |
| HPA:0570763 | 0.0119453326684 | 1.0 | ORC6 ORC2 H2AJ | testis; pachytene spermatocytes[High] |
| REAC:R-HSA-68949 | 0.0164154902665 | 0.666666666667 | ORC6 ORC2 | Orc1 removal from chromatin |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | ORC6 ORC2 H2AJ | Cell Cycle |
| REAC:R-HSA-69052 | 0.0271982878007 | 0.666666666667 | ORC6 ORC2 | Switching of origins to a post-replicative state |
| GO:0005664 | 0.0393180950424 | 0.666666666667 | ORC6 ORC2 | nuclear origin of replication recognition complex |
| GO:0000808 | 0.0393180950424 | 0.666666666667 | ORC6 ORC2 | origin recognition complex |
| REAC:R-HSA-69239 | 0.0476168581556 | 0.666666666667 | ORC6 ORC2 | Synthesis of DNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORC6 | ORC2 | 0.984 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ORC6 | H2AJ | 0.979 | 0.128 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes