hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07733.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAD2L1BP | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | 5 | UniProt NCBI |
| EPM2AIP1 | EPM2A-interacting protein 1 (Laforin-interacting protein) | 5 | UniProt NCBI |
| MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) | 5 | UniProt NCBI |
| MAD1L1 | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | 5 | UniProt NCBI |
| KIF20A | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | 5 | UniProt NCBI |
| PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) | 5 | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | 5 | UniProt NCBI |
| C15orf39 | Uncharacterized protein C15orf39 | 3 | UniProt NCBI |
| TPR | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1814 | 2.39226645298e-05 | 0.25 | MAD1L1 MAD2L1 | MAD1L1-MAD2L1 complex |
| WP:WP4240 | 0.00216982178847 | 0.25 | MAD1L1 MAD2L1 | Regulation of sister chromatid separation at the metaphase anaphase transition |
| KEGG:04110 | 0.00288562872481 | 0.375 | MAD2L1BP MAD2L1 MAD1L1 | Cell cycle |
| GO:0090266 | 0.00519447563198 | 0.375 | MAD2L1BP MAD2L1 MAD1L1 | regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:1903504 | 0.00519447563198 | 0.375 | MAD2L1BP MAD2L1 MAD1L1 | regulation of mitotic spindle checkpoint |
| GO:0090231 | 0.00610957850275 | 0.375 | MAD2L1BP MAD2L1 MAD1L1 | regulation of spindle checkpoint |
| GO:1990728 | 0.0131096201623 | 0.25 | MAD1L1 MAD2L1 | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
| GO:0090233 | 0.0393180950424 | 0.25 | MAD2L1BP MAD1L1 | negative regulation of spindle checkpoint |
| GO:0140499 | 0.0393180950424 | 0.25 | MAD2L1BP MAD1L1 | negative regulation of mitotic spindle assembly checkpoint signaling |
| GO:1902426 | 0.0393180950424 | 0.25 | MAD2L1BP MAD1L1 | deactivation of mitotic spindle assembly checkpoint |
| KEGG:04914 | 0.0421715550792 | 0.25 | MAD1L1 MAD2L1 | Progesterone-mediated oocyte maturation |
| CORUM:1813 | 0.0499436884912 | 0.125 | MAD1L1 | MAD1L1 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAD2L1BP | MAD2L1 | 1.0 | 0.164 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MAD1L1 | MAD2L1BP | 1.0 | 0.372 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| MAD1L1 | MAD2L1 | 0.999 | 0.03 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PYM1 | MAD2L1 | 0.998 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MAD2L1BP | PYROXD1 | 0.997 | 0.146 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAD2L1 | C15orf39 | 0.996 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF20A | MAD2L1BP | 0.996 | 0.154 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| EPM2AIP1 | MAD2L1 | 0.991 | 0.02 | hein_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| KIF20A | MAD2L1 | 0.989 | 0.148 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| PYM1 | MAD2L1BP | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAD2L1BP | EPM2AIP1 | 0.985 | 0.024 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAD2L1BP | C15orf39 | 0.979 | 0.176 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| KIF20A | MAD1L1 | 0.963 | 0.331102843291 | hein_WMM bioplex3_WMM WMM_only |
| TPR | MAD2L1BP | 0.956 | 0.202 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAD1L1 | C15orf39 | 0.937 | 0.078 | hein_WMM bioplex3_WMM WMM_only |
| KIF20A | C15orf39 | 0.908 | 0.328 | hein_WMM bioplex3_WMM WMM_only |
| EPM2AIP1 | PYROXD1 | 0.902 | 0.03 | bioplex3_WMM WMM_only |
| MAD1L1 | TPR | 0.901 | 0.398 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction |
| MAD1L1 | PYROXD1 | 0.892 | 0.126 | bioplex3_WMM WMM_only |
| MAD1L1 | EPM2AIP1 | 0.889 | 0.03 | hein_WMM bioplex3_WMM WMM_only |
| EPM2AIP1 | C15orf39 | 0.876 | 0.056 | hein_WMM bioplex3_WMM WMM_only |
| KIF20A | EPM2AIP1 | 0.874 | 0.0986666666667 | hein_WMM bioplex3_WMM WMM_only |
| TPR | EPM2AIP1 | 0.862 | 0.064 | hein_WMM bioplex3_WMM WMM_only |
| KIF20A | PYROXD1 | 0.768 | 0.084 | bioplex3_WMM WMM_only |
| TPR | C15orf39 | 0.639 | 0.144 | hein_WMM bioplex3_WMM WMM_only |
| KIF20A | TPR | 0.512 | 0.832 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| TPR | PYROXD1 | 0.293 | 0.15 | bioplex3_WMM WMM_only |
| TPR | MAD2L1 | 0.291 | 0.168 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PYROXD1 | MAD2L1 | 0.244 | 0.092 | bioplex3_WMM WMM_only |
| KIF20A | PYM1 | 0.137 | 0.086 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PYM1 | C15orf39 | 0.13 | bioplex3_WMM WMM_only | |
| PYM1 | PYROXD1 | 0.123 | 0.092 | bioplex3_WMM WMM_only |
| MAD1L1 | PYM1 | 0.111 | 0.072 | bioplex3_WMM WMM_only |
| PYM1 | EPM2AIP1 | 0.058 | 0.036 | bioplex3_WMM WMM_only |
| PYM1 | TPR | 0.052 | 0.134 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PYROXD1 | C15orf39 | 0.043 | 0.18 | bioplex3_WMM WMM_only |
Related Complexes