hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07734.1
Complex Portal: CPX-15172
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNLL2 | Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2) | 5 | UniProt NCBI |
| DYNLL1 | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | 5 | UniProt NCBI |
| DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) | 5 | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | 5 | UniProt NCBI |
| ZNF710 | Zinc finger protein 710 | 3 | UniProt NCBI |
| MORC3 | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | 5 | UniProt NCBI |
| ZNF608 | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 2.91694719803e-08 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 8.73363187371e-08 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 1.5157281404e-07 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Vasopressin regulated water reabsorption |
| REAC:R-HSA-9646399 | 3.59295142623e-07 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Aggrephagy |
| REAC:R-HSA-6811436 | 8.15870186193e-07 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 9.58765654383e-07 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-9663891 | 4.28820405091e-06 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Selective autophagy |
| GO:0005868 | 5.49646107354e-06 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | cytoplasmic dynein complex |
| REAC:R-HSA-141444 | 9.83039982557e-06 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 9.83039982557e-06 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 1.16796123246e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | COPI-mediated anterograde transport |
| REAC:R-HSA-69618 | 1.88046459515e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 2.25743873057e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | EML4 and NUDC in mitotic spindle formation |
| KEGG:04814 | 2.58938574941e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Motor proteins |
| REAC:R-HSA-2132295 | 2.59754704527e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 2.87672068396e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 2.97457856489e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 3.5016953291e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-1632852 | 3.5016953291e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Macroautophagy |
| GO:0030286 | 3.75057231239e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | dynein complex |
| REAC:R-HSA-5663220 | 4.22297532609e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | RHO GTPases Activate Formins |
| REAC:R-HSA-9612973 | 5.50598372696e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Autophagy |
| REAC:R-HSA-9609646 | 5.66464039369e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | HCMV Infection |
| REAC:R-HSA-199977 | 5.82668770849e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | ER to Golgi Anterograde Transport |
| KEGG:05132 | 9.46610713966e-05 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Salmonella infection |
| REAC:R-HSA-948021 | 0.00012224340869 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Transport to the Golgi and subsequent modification |
| CORUM:6038 | 0.000123103089524 | 0.285714285714 | DYNLL1 DYNC1I1 | Dynein complex |
| REAC:R-HSA-2467813 | 0.000160147629581 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Separation of Sister Chromatids |
| REAC:R-HSA-6811442 | 0.00019386485278 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 0.000202024666353 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Mitotic Prometaphase |
| CORUM:6039 | 0.000205125012531 | 0.285714285714 | DYNLL1 DYNC1I1 | Dynein-dynactin complex |
| REAC:R-HSA-68882 | 0.000345274111273 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000351493435651 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 0.000842721142757 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Cell Cycle Checkpoints |
| REAC:R-HSA-446203 | 0.000891777587572 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 0.00106596867098 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | RHO GTPase Effectors |
| CORUM:6236 | 0.00135166454364 | 0.285714285714 | DYNLL2 DYNLL1 | Dynein-2 complex, cytoplasmic |
| REAC:R-HSA-68886 | 0.00308249436511 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | M Phase |
| GO:0005875 | 0.00819856023041 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | microtubule associated complex |
| REAC:R-HSA-69278 | 0.0103191476058 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Cell Cycle, Mitotic |
| REAC:R-HSA-199991 | 0.0144304646027 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Membrane Trafficking |
| REAC:R-HSA-114452 | 0.0164719839916 | 0.285714285714 | DYNLL2 DYNLL1 | Activation of BH3-only proteins |
| REAC:R-HSA-5653656 | 0.0178473234243 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Vesicle-mediated transport |
| REAC:R-HSA-194315 | 0.0209047694901 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.0227764210725 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Cell Cycle |
| REAC:R-HSA-1280218 | 0.0256603099606 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Adaptive Immune System |
| WP:WP4906 | 0.028073243565 | 0.285714285714 | DYNLL2 DYNLL1 | 3q29 copy number variation syndrome |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Viral Infection Pathways |
| REAC:R-HSA-2262752 | 0.0357359015554 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.037098775361 | 0.571428571429 | DYNC1LI2 DYNLL2 DYNLL1 DYNC1I1 | Cellular responses to stimuli |
| REAC:R-HSA-5620924 | 0.0480490075434 | 0.285714285714 | DYNLL2 DYNLL1 | Intraflagellar transport |
| REAC:R-HSA-109606 | 0.0499595563988 | 0.285714285714 | DYNLL2 DYNLL1 | Intrinsic Pathway for Apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I1 | DYNC1LI2 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I1 | DYNLL1 | 0.997 | 0.214 |
mutually_exclusive (Q96FJ2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DYNLL1 | MORC3 | 0.995 | 0.222 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| DYNC1I1 | DYNLL2 | 0.995 | 0.136 |
mutually_exclusive (P63167)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DYNLL2 | DYNLL1 | 0.99 | 0.214 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| DYNC1LI2 | DYNLL1 | 0.98 | 0.21 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | |
| DYNLL2 | MORC3 | 0.979 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| DYNC1LI2 | DYNLL2 | 0.962 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| DYNLL1 | ZNF710 | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DYNLL1 | ZNF608 | 0.954 | 0.342 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| DYNLL2 | ZNF608 | 0.897 | 0.142 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DYNLL2 | ZNF710 | 0.89 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZNF710 | ZNF608 | 0.391 | bioplex3_WMM WMM_only | ||
| DYNC1I1 | ZNF710 | 0.287 | bioplex3_WMM WMM_only | ||
| ZNF710 | MORC3 | 0.135 | bioplex3_WMM WMM_only | ||
| DYNC1I1 | ZNF608 | 0.123 | 0.106 | bioplex3_WMM WMM_only | |
| MORC3 | ZNF608 | 0.114 | 0.152 | bioplex3_WMM youn_WMM WMM_only | |
| DYNC1LI2 | MORC3 | 0.111 | 0.048 | bioplex3_WMM WMM_only | |
| DYNC1LI2 | ZNF710 | 0.095 | bioplex3_WMM WMM_only | ||
| DYNC1LI2 | ZNF608 | 0.081 | 0.096 | bioplex3_WMM WMM_only | |
| DYNC1I1 | MORC3 | 0.079 | 0.116 | bioplex3_WMM WMM_only |
Related Complexes