hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07760.1
Complex Portal: CPX-25264
Confidence: High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
ARPC1B | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | 5 | UniProt   NCBI |
ARPC5 | Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) | 5 | UniProt   NCBI |
ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | 4 | UniProt   NCBI |
ARPC1A | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | 4 | UniProt   NCBI |
ARPC3 | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0005885 | 1.13455325e-12 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Arp2/3 protein complex |
  WP:WP2272 | 2.15707649316e-11 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Pathogenic Escherichia coli infection |
  KEGG:05100 | 1.61509398715e-10 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Bacterial invasion of epithelial cells |
  KEGG:04666 | 3.84210085102e-10 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Fc gamma R-mediated phagocytosis |
  KEGG:05135 | 1.34170798668e-09 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Yersinia infection |
  KEGG:04530 | 3.51498113927e-09 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Tight junction |
  GO:0034314 | 5.92496122958e-09 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Arp2/3 complex-mediated actin nucleation |
  KEGG:05130 | 8.38092888589e-09 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Pathogenic Escherichia coli infection |
  GO:0045010 | 1.10011955886e-08 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin nucleation |
  KEGG:04810 | 1.95058156152e-08 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Regulation of actin cytoskeleton |
  REAC:R-HSA-5663213 | 1.97771129067e-08 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | RHO GTPases Activate WASPs and WAVEs |
  REAC:R-HSA-3928662 | 3.1471608967e-08 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | EPHB-mediated forward signaling |
  KEGG:05132 | 3.92786613897e-08 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Salmonella infection |
  KEGG:05131 | 4.20054425095e-08 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Shigellosis |
  KEGG:04144 | 4.58745556677e-08 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | Endocytosis |
  CORUM:27 | 9.80414034403e-08 | 0.6 | ARPC5 ARPC1B ARPC3 | Arp2/3 protein complex |
  REAC:R-HSA-9664422 | 1.24745525372e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | FCGR3A-mediated phagocytosis |
  REAC:R-HSA-9664407 | 1.24745525372e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Parasite infection |
  REAC:R-HSA-9664417 | 1.24745525372e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Leishmania phagocytosis |
  REAC:R-HSA-2029482 | 1.5644237257e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Regulation of actin dynamics for phagocytic cup formation |
  REAC:R-HSA-2029480 | 6.0683312796e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Fcgamma receptor (FCGR) dependent phagocytosis |
  REAC:R-HSA-2682334 | 7.43925651437e-07 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | EPH-Ephrin signaling |
  REAC:R-HSA-9658195 | 5.78164213131e-06 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Leishmania infection |
  REAC:R-HSA-9824443 | 5.78164213131e-06 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Parasitic Infection Pathways |
  GO:0051015 | 9.74490439673e-06 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin filament binding |
  GO:0003779 | 0.000115876930584 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin binding |
  REAC:R-HSA-195258 | 0.000131735072349 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | RHO GTPase Effectors |
  GO:0007015 | 0.000316575847845 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin filament organization |
  GO:0015629 | 0.000549054657097 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin cytoskeleton |
  REAC:R-HSA-422475 | 0.000923896701883 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Axon guidance |
  REAC:R-HSA-9675108 | 0.00106922987368 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Nervous system development |
  REAC:R-HSA-8856828 | 0.00120721178545 | 0.6 | ARPC5 ARPC3 ARPC1A | Clathrin-mediated endocytosis |
  REAC:R-HSA-194315 | 0.00268190833433 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Signaling by Rho GTPases |
  REAC:R-HSA-9716542 | 0.00292664866109 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
  GO:0030036 | 0.0031084486219 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin cytoskeleton organization |
  GO:0030029 | 0.00536447113949 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | actin filament-based process |
  GO:0097435 | 0.00598210017998 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | supramolecular fiber organization |
  REAC:R-HSA-1266738 | 0.00896294496653 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Developmental Biology |
  REAC:R-HSA-5663205 | 0.00938555933211 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Infectious disease |
  REAC:R-HSA-168249 | 0.0104601875414 | 0.8 | ARPC5 ARPC3 ARPC1B ARPC1A | Innate Immune System |
  GO:0008092 | 0.0133485794118 | 1.0 | ARPC5 ARPC3 ARPC1A ARPC1B ARPC5L | cytoskeletal protein binding |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
 ARPC1A |  ARPC3 | 1.0 | 0.324           |          | hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     gupta_WMM     fraction     |
 ARPC1A |  ARPC5 | 1.0 | 0.184           |
structurally_consistent (dimer)        
|
hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC1A |  ARPC5L | 1.0 | 0.176           |
structurally_consistent (dimer)        
|
hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC3 |  ARPC5L | 1.0 | 0.282           |          | hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC1B |  ARPC3 | 0.999 | 0.846           |          | hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC5 |  ARPC3 | 0.999 | 0.936           |          | hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC1B |  ARPC5 | 0.999 | 0.806           |
structurally_consistent (dimer)        
|
hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     bioplex3_HCT116     fraction     |
 ARPC1B |  ARPC5L | 0.998 | 0.08           |
structurally_consistent (Q9P1U1)        
|
hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     fraction     |
 ARPC5 |  ARPC5L | 0.998 | 0.168           |
mutually_exclusive (P61160)        
|
hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only     |
 ARPC1A |  ARPC1B | 0.987 | 0.212           |
mutually_exclusive (O15511)        
structurally_consistent (dimer)         |
hein_WMM     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     fraction     |
Related Complexes