hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07767.1
Complex Portal: CPX-24391
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | 5 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
| CBLB | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | 5 | UniProt NCBI |
| ERRFI1 | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | 5 | UniProt NCBI |
| ARHGEF35 | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | 2 | UniProt NCBI |
| ARHGEF5 | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | 5 | UniProt NCBI |
| NKX2-5 | Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP437 | 0.000178433597202 | 0.4 | GRB2 CBLB SOS2 ERRFI1 | EGF EGFR signaling pathway |
| REAC:R-HSA-193648 | 0.00067784244969 | 0.3 | ARHGEF5 SOS2 ARHGEF35 | NRAGE signals death through JNK |
| KEGG:04012 | 0.000795418612239 | 0.3 | CBLB SOS2 GRB2 | ErbB signaling pathway |
| REAC:R-HSA-204998 | 0.00159905965802 | 0.3 | ARHGEF5 SOS2 ARHGEF35 | Cell death signalling via NRAGE, NRIF and NADE |
| WP:WP673 | 0.00188362598587 | 0.3 | CBLB SOS2 GRB2 | ErbB signaling pathway |
| KEGG:04660 | 0.00198163198395 | 0.3 | CBLB SOS2 GRB2 | T cell receptor signaling pathway |
| REAC:R-HSA-416482 | 0.00206314708251 | 0.3 | ARHGEF5 SOS2 ARHGEF35 | G alpha (12/13) signalling events |
| REAC:R-HSA-193704 | 0.00352101579197 | 0.3 | ARHGEF5 SOS2 ARHGEF35 | p75 NTR receptor-mediated signalling |
| KEGG:04910 | 0.00361713493347 | 0.3 | CBLB SOS2 GRB2 | Insulin signaling pathway |
| WP:WP4928 | 0.00375768007348 | 0.2 | SOS2 GAREM2 | MAPK pathway in congenital thyroid cancer |
| KEGG:05206 | 0.00583642418014 | 0.3 | GLS2 SOS2 GRB2 | MicroRNAs in cancer |
| REAC:R-HSA-8983432 | 0.00790724004214 | 0.2 | GRB2 SOS2 | Interleukin-15 signaling |
| WP:WP481 | 0.0103021460703 | 0.3 | CBLB SOS2 GRB2 | Insulin signaling |
| WP:WP422 | 0.0144252840529 | 0.2 | GRB2 SOS2 | MAPK cascade |
| REAC:R-HSA-73887 | 0.0177651546753 | 0.3 | ARHGEF5 SOS2 ARHGEF35 | Death Receptor Signaling |
| KEGG:05213 | 0.0276255594722 | 0.2 | GRB2 SOS2 | Endometrial cancer |
| KEGG:04664 | 0.0286984339403 | 0.2 | GRB2 SOS2 | Fc epsilon RI signaling pathway |
| WP:WP4535 | 0.0287758668954 | 0.2 | GRB2 SOS2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05221 | 0.0355555587532 | 0.2 | GRB2 SOS2 | Acute myeloid leukemia |
| KEGG:04917 | 0.0392530380302 | 0.2 | GRB2 SOS2 | Prolactin signaling pathway |
| KEGG:05211 | 0.0431289933515 | 0.2 | GRB2 SOS2 | Renal cell carcinoma |
| KEGG:05223 | 0.047182824951 | 0.2 | GRB2 SOS2 | Non-small cell lung cancer |
| KEGG:04662 | 0.047182824951 | 0.2 | GRB2 SOS2 | B cell receptor signaling pathway |
| KEGG:05214 | 0.047182824951 | 0.2 | GRB2 SOS2 | Glioma |
| KEGG:04912 | 0.047182824951 | 0.2 | GRB2 SOS2 | GnRH signaling pathway |
| CORUM:2540 | 0.0499436884912 | 0.1 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:2892 | 0.0499436884912 | 0.1 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2895 | 0.0499436884912 | 0.1 | GRB2 | SHC-GRB2 complex |
| CORUM:3096 | 0.0499436884912 | 0.1 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ERRFI1 | GRB2 | 0.998 | 0.202 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARHGEF35 | ARHGEF5 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| GRB2 | GAREM2 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GRB2 | CBLB | 0.984 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GLS2 | GRB2 | 0.974 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ARHGEF35 | GRB2 | 0.965 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NKX2-5 | GRB2 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ARHGEF5 | GRB2 | 0.954 | 0.134 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SOS2 | ARHGEF35 | 0.904 | bioplex3_WMM WMM_only | ||
| ERRFI1 | ARHGEF35 | 0.904 | bioplex3_WMM WMM_only | ||
| SOS2 | ARHGEF5 | 0.869 | 0.092 | bioplex3_WMM WMM_only | |
| SOS2 | ERRFI1 | 0.844 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| ERRFI1 | ARHGEF5 | 0.626 | 0.15 | bioplex3_WMM WMM_only | |
| C16orf96 | CBLB | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | ERRFI1 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | SOS2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | GAREM2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CBLB | GAREM2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ERRFI1 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SOS2 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | C16orf96 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ERRFI1 | CBLB | 0.303 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | CBLB | 0.265 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARHGEF5 | GAREM2 | 0.214 | bioplex3_WMM WMM_only | ||
| C16orf96 | ARHGEF35 | 0.214 | bioplex3_WMM WMM_only | ||
| ARHGEF35 | GAREM2 | 0.214 | bioplex3_WMM WMM_only | ||
| C16orf96 | ARHGEF5 | 0.214 | bioplex3_WMM WMM_only | ||
| NKX2-5 | GAREM2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | ERRFI1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | CBLB | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | SOS2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARHGEF35 | CBLB | 0.146 | bioplex3_WMM WMM_only | ||
| GLS2 | GAREM2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | GLS2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ERRFI1 | GLS2 | 0.11 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GLS2 | 0.11 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only | |
| NKX2-5 | GLS2 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GLS2 | CBLB | 0.11 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARHGEF5 | CBLB | 0.108 | 0.094 | bioplex3_WMM WMM_only | |
| NKX2-5 | ARHGEF35 | 0.046 | bioplex3_WMM WMM_only | ||
| NKX2-5 | ARHGEF5 | 0.043 | bioplex3_WMM WMM_only | ||
| ARHGEF35 | GLS2 | 0.015 | bioplex3_WMM WMM_only | ||
| ARHGEF5 | GLS2 | 0.015 | 0.104 | bioplex3_WMM WMM_only |
Related Complexes