hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07775.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC23IP | SEC23-interacting protein (p125) | 5 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1982 | 1.34130161218e-07 | 0.8 | SEC23A SEC24C SEC24D SEC23B | Sterol regulatory element binding proteins SREBP signaling |
| GO:0030134 | 1.35248958379e-07 | 1.0 | SEC23A SEC23B SEC24C SEC24D SEC23IP | COPII-coated ER to Golgi transport vesicle |
| REAC:R-HSA-204005 | 2.22216287327e-07 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | COPII-mediated vesicle transport |
| GO:0030127 | 2.39287617466e-07 | 0.8 | SEC23A SEC24C SEC24D SEC23B | COPII vesicle coat |
| GO:0090110 | 2.39287617466e-07 | 0.8 | SEC23A SEC24C SEC24D SEC23B | COPII-coated vesicle cargo loading |
| GO:0070971 | 1.96449993261e-06 | 0.8 | SEC23A SEC24C SEC24D SEC23B | endoplasmic reticulum exit site |
| KEGG:04141 | 3.00693972585e-06 | 0.8 | SEC23A SEC24C SEC24D SEC23B | Protein processing in endoplasmic reticulum |
| GO:0035459 | 4.13351489328e-06 | 0.8 | SEC23A SEC24C SEC24D SEC23B | vesicle cargo loading |
| REAC:R-HSA-199977 | 7.07988042852e-06 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | ER to Golgi Anterograde Transport |
| REAC:R-HSA-5694530 | 9.10580767182e-06 | 0.6 | SEC23A SEC24C SEC24D | Cargo concentration in the ER |
| REAC:R-HSA-983170 | 9.10580767182e-06 | 0.6 | SEC23A SEC24C SEC24D | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| GO:0090114 | 1.08004637014e-05 | 0.8 | SEC23A SEC24C SEC24D SEC23B | COPII-coated vesicle budding |
| REAC:R-HSA-948021 | 1.49011277783e-05 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | Transport to the Golgi and subsequent modification |
| GO:0012507 | 2.55378856908e-05 | 0.8 | SEC23A SEC24C SEC24D SEC23B | ER to Golgi transport vesicle membrane |
| GO:0030135 | 3.95539627218e-05 | 1.0 | SEC23A SEC23B SEC24C SEC24D SEC23IP | coated vesicle |
| GO:0030120 | 5.18179525184e-05 | 0.8 | SEC23A SEC24C SEC24D SEC23B | vesicle coat |
| REAC:R-HSA-1655829 | 6.08725504416e-05 | 0.6 | SEC23A SEC24C SEC24D | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-446203 | 0.00011004914384 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | Asparagine N-linked glycosylation |
| GO:0006900 | 0.000134846916955 | 0.8 | SEC23A SEC24C SEC24D SEC23B | vesicle budding from membrane |
| CORUM:7141 | 0.000136445626745 | 0.4 | SEC23A SEC23IP | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| GO:0048475 | 0.00029151492518 | 0.8 | SEC23A SEC24C SEC24D SEC23B | coated membrane |
| GO:0030117 | 0.00029151492518 | 0.8 | SEC23A SEC24C SEC24D SEC23B | membrane coat |
| REAC:R-HSA-9705671 | 0.000703352922832 | 0.6 | SEC23A SEC24C SEC24D | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-2132295 | 0.000802337674321 | 0.6 | SEC23A SEC24C SEC24D | MHC class II antigen presentation |
| GO:0030658 | 0.000904012985399 | 0.8 | SEC23A SEC24C SEC24D SEC23B | transport vesicle membrane |
| REAC:R-HSA-8957322 | 0.000910160054501 | 0.6 | SEC23A SEC24C SEC24D | Metabolism of steroids |
| GO:0006888 | 0.00100329218716 | 0.8 | SEC23A SEC24C SEC24D SEC23B | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-199991 | 0.00183945180572 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00228321498701 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | Vesicle-mediated transport |
| HP:0002868 | 0.00230672366147 | 0.4 | SEC23A SEC24D | Narrow iliac wing |
| GO:0030662 | 0.00243730532859 | 0.8 | SEC23A SEC24C SEC24D SEC23B | coated vesicle membrane |
| REAC:R-HSA-9705683 | 0.00333687251766 | 0.6 | SEC23A SEC24C SEC24D | SARS-CoV-2-host interactions |
| REAC:R-HSA-9694516 | 0.0101788028745 | 0.6 | SEC23A SEC24C SEC24D | SARS-CoV-2 Infection |
| REAC:R-HSA-983169 | 0.020613248155 | 0.6 | SEC23A SEC24C SEC24D | Class I MHC mediated antigen processing & presentation |
| GO:0030133 | 0.021291146538 | 0.8 | SEC23A SEC24C SEC24D SEC23B | transport vesicle |
| HP:0000765 | 0.0258778007249 | 0.8 | SEC23A SEC24C SEC24D SEC23B | Abnormal thorax morphology |
| REAC:R-HSA-9679506 | 0.0263889851162 | 0.6 | SEC23A SEC24C SEC24D | SARS-CoV Infections |
| GO:0048193 | 0.0280745884658 | 0.8 | SEC23A SEC24C SEC24D SEC23B | Golgi vesicle transport |
| GO:0016050 | 0.0329457298686 | 0.8 | SEC23A SEC24C SEC24D SEC23B | vesicle organization |
| REAC:R-HSA-597592 | 0.0380600523345 | 0.8 | SEC23A SEC24C SEC24D SEC23IP | Post-translational protein modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC23B | SEC24C | 1.0 | 0.268 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24C | 1.0 | 0.53 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC23IP | 0.995 | 0.254 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| SEC23B | SEC24D | 0.993 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC23B | SEC23IP | 0.99 | 0.092 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SEC23A | SEC24D | 0.981 | 0.302631578947 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24C | 0.602 | 0.136 | bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC23IP | 0.106 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| SEC23IP | SEC24C | 0.07 | 0.516 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM |
Related Complexes