hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07776.1

Complex Portal: CPX-25335

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
CORO1A	Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)	5	UniProt NCBI
CFL1	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)	5	UniProt NCBI
CORO1B	Coronin-1B (Coronin-2)	5	UniProt NCBI
AFAP1	Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)	5	UniProt NCBI
SYNPO	Synaptopodin	5	UniProt NCBI
DSTN	Destrin (Actin-depolymerizing factor) (ADF)	5	UniProt NCBI
CORO1C	Coronin-1C (Coronin-3) (hCRNN4)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0015629	3.531185303e-07	1.0	CORO1C CFL1 CORO1A DSTN AFAP1 CORO1B SYNPO	actin cytoskeleton
GO:0003779	1.48074113953e-05	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	actin binding
GO:0007015	4.93794774748e-05	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	actin filament organization
GO:0051015	0.00020083270634	0.714285714286	CORO1A DSTN CORO1B CORO1C CFL1	actin filament binding
GO:0030036	0.000759257961222	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	actin cytoskeleton organization
GO:0030029	0.00145686134313	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	actin filament-based process
GO:0097435	0.00165926194876	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	supramolecular fiber organization
GO:0008092	0.0043226725106	0.857142857143	CORO1C CFL1 CORO1A DSTN SYNPO CORO1B	cytoskeletal protein binding
GO:0005856	0.00665123557963	1.0	CORO1C CFL1 CORO1A DSTN AFAP1 CORO1B SYNPO	cytoskeleton
GO:0030027	0.00874901431253	0.571428571429	CORO1A CORO1B CORO1C CFL1	lamellipodium
GO:0030043	0.0294899169624	0.285714285714	CFL1 DSTN	actin filament fragmentation

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CORO1B	CORO1A	0.999	0.104	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
CORO1B	CORO1C	0.999	0.188	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
CORO1A	CORO1C	0.998	0.08	mutually_exclusive (Q9BR76) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM
DSTN	AFAP1	0.993			hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CFL1	DSTN	0.983	0.572		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
DSTN	CORO1C	0.981	0.304		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
CFL1	CORO1C	0.965	0.184		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
SYNPO	CORO1C	0.963			hein_WMM hein ()
CORO1C	AFAP1	0.963			hein_WMM hein ()
CFL1	AFAP1	0.952			hein_WMM bioplex_WMM bioplex3_WMM WMM_only
SYNPO	DSTN	0.781			hein_WMM WMM_only
CORO1B	AFAP1	0.773			hein_WMM WMM_only
SYNPO	AFAP1	0.773			hein_WMM WMM_only
CORO1B	SYNPO	0.773			hein_WMM WMM_only
SYNPO	CFL1	0.764			hein_WMM WMM_only
CORO1B	DSTN	0.758	0.19		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
CORO1B	CFL1	0.74	0.146		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CORO1A	DSTN	0.065	0.07		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CORO1A	CFL1	0.003	0.396		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM

Related Complexes

Genename	Complexes
CORO1A	huMAP3_01075.1 huMAP3_04263.1 huMAP3_04826.1 huMAP3_05614.1 huMAP3_07117.1 huMAP3_07351.1 huMAP3_07776.1 huMAP3_09579.1 huMAP3_09596.1 huMAP3_09808.1 huMAP3_10784.1 huMAP3_11076.1
CFL1	huMAP3_03395.1 huMAP3_03694.1 huMAP3_05614.1 huMAP3_06125.1 huMAP3_07776.1 huMAP3_09579.1 huMAP3_11076.1 huMAP3_14124.1
CORO1B	huMAP3_01075.1 huMAP3_02173.1 huMAP3_03762.1 huMAP3_04263.1 huMAP3_04826.1 huMAP3_05614.1 huMAP3_06395.1 huMAP3_07117.1 huMAP3_07351.1 huMAP3_07776.1 huMAP3_08255.1 huMAP3_09579.1 huMAP3_09596.1 huMAP3_09808.1 huMAP3_10673.1 huMAP3_10784.1 huMAP3_11076.1
AFAP1	huMAP3_03694.1 huMAP3_05614.1 huMAP3_07776.1 huMAP3_09121.1 huMAP3_09579.1 huMAP3_11076.1
SYNPO	huMAP3_01606.1 huMAP3_03689.1 huMAP3_04826.1 huMAP3_05057.1 huMAP3_05614.1 huMAP3_06017.1 huMAP3_07776.1 huMAP3_09555.1 huMAP3_09579.1 huMAP3_10270.1 huMAP3_10784.1 huMAP3_11076.1 huMAP3_12531.1 huMAP3_15295.1
DSTN	huMAP3_03395.1 huMAP3_03694.1 huMAP3_05614.1 huMAP3_06125.1 huMAP3_07776.1 huMAP3_09555.1 huMAP3_09579.1 huMAP3_11076.1
CORO1C	huMAP3_03689.1 huMAP3_04826.1 huMAP3_05614.1 huMAP3_07776.1 huMAP3_09555.1 huMAP3_09579.1 huMAP3_10784.1 huMAP3_11076.1