hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07779.1

Complex Portal: CPX-25318

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
CLMN	Calmin (Calponin-like transmembrane domain protein)	4	UniProt NCBI
EPHX4	Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein)	3	UniProt NCBI
SUGCT	Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase)	5	UniProt NCBI
ABHD17C	Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22)	5	UniProt NCBI
ORAI1	Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)	5	UniProt NCBI
OCIAD2	OCIA domain-containing protein 2 (Ovarian carcinoma immunoreactive antigen-like protein)	3	UniProt NCBI
P2RY10	Putative P2Y purinoceptor 10 (P2Y10) (P2Y-like receptor)	4	UniProt NCBI
PLPP6	Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase)	5	UniProt NCBI
GPR45	Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha)	4	UniProt NCBI
PIGX	Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X)	4	UniProt NCBI
AASS	Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]	5	UniProt NCBI
GUF1	Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase)	4	UniProt NCBI
SGSM3	Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP)	5	UniProt NCBI
TUBE1	Tubulin epsilon chain (Epsilon-tubulin)	3	UniProt NCBI
GCDH	Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)	5	UniProt NCBI
PYROXD2	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-)	4	UniProt NCBI
HSD17B7	3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0034688	0.0013842456072	0.117647058824	SUGCT GCDH	Reduced peroxisomal glutaryl-CoA oxidase activity
HP:0003530	0.013814058389	0.117647058824	SUGCT GCDH	Elevated circulating glutaric acid concentration
HP:0003150	0.0207069091434	0.117647058824	SUGCT GCDH	Glutaric aciduria
REAC:R-HSA-71064	0.0224557028643	0.117647058824	AASS GCDH	Lysine catabolism
CORUM:828	0.0497089104684	0.0588235294118	ORAI1	TRPC1-STIM1-ORAI1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GPR45	TUBE1	0.999		structurally_consistent (dimer)
SUGCT	GPR45	0.998
OCIAD2	GPR45	0.998
ABHD17C	GPR45	0.998
ORAI1	GPR45	0.997
GPR45	SGSM3	0.997
GPR45	PYROXD2	0.997
CLMN	GPR45	0.996
HSD17B7	GPR45	0.996
PIGX	GPR45	0.993
HSD17B7	P2RY10	0.993
GUF1	GPR45	0.991
P2RY10	ABHD17C	0.987
PLPP6	GPR45	0.984
AASS	GPR45	0.981
GPR45	GCDH	0.975
ORAI1	GCDH	0.975	0.056
P2RY10	TUBE1	0.964		structurally_consistent (dimer)
ORAI1	AASS	0.962	0.04
ORAI1	PIGX	0.961	0.1
EPHX4	GPR45	0.96
ORAI1	HSD17B7	0.955	0.042
GUF1	AASS	0.85	0.01
PLPP6	TUBE1	0.812	0.08
ABHD17C	PLPP6	0.811
AASS	TUBE1	0.811	0.062
SUGCT	GCDH	0.807	0.096
ORAI1	PLPP6	0.772	0.072
SGSM3	PYROXD2	0.768
CLMN	GCDH	0.768	0.008
AASS	PLPP6	0.752	0.026
AASS	GCDH	0.748	0.048
PYROXD2	TUBE1	0.73
ORAI1	PYROXD2	0.715
EPHX4	SGSM3	0.714	0.09
OCIAD2	PYROXD2	0.703
ORAI1	GUF1	0.701	0.064
CLMN	EPHX4	0.7	0.048
AASS	SGSM3	0.677	0.044
ABHD17C	PYROXD2	0.676
SGSM3	TUBE1	0.675	0.074
ORAI1	CLMN	0.675	0.046
ORAI1	ABHD17C	0.675
ORAI1	TUBE1	0.675	0.102
ORAI1	OCIAD2	0.675	0.034
ORAI1	SUGCT	0.675	0.074
ORAI1	SGSM3	0.675	0.07
PLPP6	GCDH	0.651	0.04
ABHD17C	CLMN	0.633
EPHX4	PLPP6	0.624	0.08
PLPP6	PYROXD2	0.602
AASS	PYROXD2	0.594
PIGX	EPHX4	0.578	0.1
PLPP6	SGSM3	0.557	0.082
GUF1	TUBE1	0.552	0.12
HSD17B7	PLPP6	0.55	0.058
P2RY10	GUF1	0.542
SUGCT	SGSM3	0.522	0.038
ABHD17C	EPHX4	0.518
ABHD17C	AASS	0.504
PIGX	HSD17B7	0.495	0.07
SUGCT	GUF1	0.48	0.034
ABHD17C	TUBE1	0.479
ABHD17C	OCIAD2	0.468
HSD17B7	AASS	0.458	0.016
OCIAD2	GCDH	0.451	0.018
PIGX	GUF1	0.444	0.056
CLMN	PLPP6	0.439	0.052
SUGCT	PYROXD2	0.427
CLMN	PYROXD2	0.427
PIGX	ABHD17C	0.405
ABHD17C	SGSM3	0.405
OCIAD2	SGSM3	0.405	0.046
PIGX	TUBE1	0.405	0.108
CLMN	OCIAD2	0.401	0.044
SUGCT	OCIAD2	0.401	0.036
SGSM3	GCDH	0.398	0.096
ORAI1	EPHX4	0.395	0.08
PIGX	SGSM3	0.389	0.078
GUF1	GCDH	0.388	0.128
OCIAD2	TUBE1	0.388	0.034
EPHX4	TUBE1	0.38	0.134
GCDH	TUBE1	0.376	0.062
HSD17B7	SUGCT	0.367	0.038
ABHD17C	GUF1	0.366
CLMN	SGSM3	0.364	0.046
SUGCT	TUBE1	0.364	0.096
HSD17B7	OCIAD2	0.356	0.012
GUF1	PYROXD2	0.356
ABHD17C	SUGCT	0.356
CLMN	TUBE1	0.345	0.052
HSD17B7	PYROXD2	0.343
SUGCT	CLMN	0.343	0.046
HSD17B7	SGSM3	0.343	0.018
SUGCT	AASS	0.332	0.064
GUF1	OCIAD2	0.315	0.014
HSD17B7	CLMN	0.312	0.024
HSD17B7	ABHD17C	0.307
HSD17B7	GCDH	0.303	0.02
PIGX	SUGCT	0.302	0.052
AASS	EPHX4	0.284	0.046
HSD17B7	TUBE1	0.283	0.04
HSD17B7	GUF1	0.272	0.01
GUF1	SGSM3	0.267	0.088
PIGX	CLMN	0.264	0.048
PIGX	OCIAD2	0.261	0.044
GUF1	CLMN	0.261	0.042
OCIAD2	PLPP6	0.259	0.042
SUGCT	PLPP6	0.258	0.086
PIGX	PYROXD2	0.257
AASS	OCIAD2	0.253	0.026
GUF1	PLPP6	0.226	0.082
PIGX	AASS	0.223	0.038
CLMN	AASS	0.208	0.048
ABHD17C	GCDH	0.198
HSD17B7	EPHX4	0.195	0.064
PYROXD2	GCDH	0.174
PIGX	P2RY10	0.162
EPHX4	PYROXD2	0.154
GUF1	EPHX4	0.151	0.07
PIGX	GCDH	0.148	0.058
EPHX4	OCIAD2	0.147	0.042
P2RY10	PLPP6	0.116
EPHX4	GCDH	0.101	0.04
PIGX	PLPP6	0.085	0.132
SUGCT	EPHX4	0.063	0.044
P2RY10	AASS	0.061
P2RY10	EPHX4	0.04
P2RY10	GCDH	0.028

Related Complexes

Genename	Complexes
CLMN	huMAP3_03237.1 huMAP3_03623.1 huMAP3_04048.1 huMAP3_05818.1 huMAP3_06562.1 huMAP3_07631.1 huMAP3_07651.1 huMAP3_07779.1 huMAP3_08668.1 huMAP3_10457.1
EPHX4	huMAP3_03580.1 huMAP3_07685.1 huMAP3_07779.1
SUGCT	huMAP3_00867.1 huMAP3_03623.1 huMAP3_06623.1 huMAP3_07779.1 huMAP3_12841.1
ABHD17C	huMAP3_00434.1 huMAP3_02088.1 huMAP3_03654.1 huMAP3_07539.1 huMAP3_07779.1 huMAP3_08668.1 huMAP3_11067.1
ORAI1	huMAP3_00203.1 huMAP3_02843.1 huMAP3_03295.1 huMAP3_07779.1 huMAP3_10494.1
OCIAD2	huMAP3_03623.1 huMAP3_06562.1 huMAP3_07779.1 huMAP3_11801.1 huMAP3_12613.1 huMAP3_13101.1 huMAP3_13533.1 huMAP3_13549.1 huMAP3_14350.1
P2RY10	huMAP3_00259.1 huMAP3_00434.1 huMAP3_02088.1 huMAP3_05117.1 huMAP3_07779.1 huMAP3_10202.1 huMAP3_11365.1 huMAP3_12857.1 huMAP3_13989.1
PLPP6	huMAP3_03623.1 huMAP3_04048.1 huMAP3_06562.1 huMAP3_07631.1 huMAP3_07779.1 huMAP3_08668.1
GPR45	huMAP3_03623.1 huMAP3_06562.1 huMAP3_07779.1
PIGX	huMAP3_00203.1 huMAP3_02843.1 huMAP3_03295.1 huMAP3_06634.1 huMAP3_07708.1 huMAP3_07779.1 huMAP3_07785.1 huMAP3_08016.1 huMAP3_10494.1
AASS	huMAP3_03295.1 huMAP3_04153.1 huMAP3_05108.1 huMAP3_05791.1 huMAP3_06263.1 huMAP3_07779.1 huMAP3_08568.1 huMAP3_09247.1 huMAP3_09408.1 huMAP3_10273.1
GUF1	huMAP3_01763.1 huMAP3_03623.1 huMAP3_04167.1 huMAP3_07779.1 huMAP3_07849.1 huMAP3_08420.1 huMAP3_09333.1 huMAP3_09853.1 huMAP3_10410.1
SGSM3	huMAP3_03623.1 huMAP3_06562.1 huMAP3_07779.1
TUBE1	huMAP3_07018.1 huMAP3_07779.1 huMAP3_12425.1
GCDH	huMAP3_05796.1 huMAP3_07670.1 huMAP3_07779.1 huMAP3_08568.1 huMAP3_09247.1 huMAP3_10494.1 huMAP3_12841.1 huMAP3_13580.1
PYROXD2	huMAP3_03623.1 huMAP3_06562.1 huMAP3_07779.1 huMAP3_12500.1 huMAP3_13849.1 huMAP3_14343.1
HSD17B7	huMAP3_00203.1 huMAP3_00434.1 huMAP3_05117.1 huMAP3_07779.1 huMAP3_10494.1 huMAP3_12857.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07779.1

Complex Portal: CPX-25318