hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07781.1
Complex Portal: CPX-16813
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDAP1 | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | 4 | UniProt NCBI |
| RTRAF | RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE) | 5 | UniProt NCBI |
| IFI16 | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | 5 | UniProt NCBI |
| DEK | Protein DEK | 5 | UniProt NCBI |
| RTCB | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) | 5 | UniProt NCBI |
| DDX1 | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | 5 | UniProt NCBI |
| GTPBP1 | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6301 | 7.02050133195e-08 | 0.428571428571 | RTRAF RTCB DDX1 | tRNA Splicing Ligase Complex |
| GO:0072669 | 0.0001882019462 | 0.428571428571 | RTRAF RTCB DDX1 | tRNA-splicing ligase complex |
| REAC:R-HSA-6784531 | 0.0003384553812 | 0.428571428571 | RTRAF RTCB DDX1 | tRNA processing in the nucleus |
| GO:0006388 | 0.000554182028596 | 0.428571428571 | RTRAF RTCB DDX1 | tRNA splicing, via endonucleolytic cleavage and ligation |
| GO:0000394 | 0.000738757615619 | 0.428571428571 | RTRAF RTCB DDX1 | RNA splicing, via endonucleolytic cleavage and ligation |
| REAC:R-HSA-72306 | 0.00200524097522 | 0.428571428571 | RTRAF RTCB DDX1 | tRNA processing |
| HPA:0340462 | 0.00281781692095 | 0.857142857143 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 | ovary; ovarian stroma cells[>=Medium] |
| GO:0003723 | 0.00365068293209 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | RNA binding |
| HPA:0340461 | 0.00586430866902 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | ovary; ovarian stroma cells[>=Low] |
| HPA:0160251 | 0.00675933198392 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | endometrium 1; cells in endometrial stroma[>=Low] |
| HPA:0530721 | 0.0102359031903 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | spleen; cells in white pulp[>=Low] |
| HPA:0030071 | 0.0181110839557 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | appendix; lymphoid tissue[>=Low] |
| HPA:0351183 | 0.020846073103 | 0.571428571429 | PDAP1 RTCB DDX1 RTRAF | pancreas; pancreatic endocrine cells[High] |
| HPA:0270352 | 0.027723772473 | 0.857142857143 | DEK GTPBP1 RTRAF DDX1 IFI16 PDAP1 | kidney; cells in glomeruli[>=Medium] |
| HPA:0490692 | 0.029093044107 | 0.857142857143 | DEK GTPBP1 RTRAF DDX1 PDAP1 RTCB | smooth muscle; smooth muscle cells[>=Medium] |
| HPA:0310431 | 0.0297680326582 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | lymph node; germinal center cells[>=Low] |
| HPA:0270351 | 0.0313594015773 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | kidney; cells in glomeruli[>=Low] |
| HPA:0170252 | 0.0319022744941 | 0.714285714286 | DEK RTRAF GTPBP1 DDX1 IFI16 | endometrium 2; cells in endometrial stroma[>=Medium] |
| HPA:0460671 | 0.0393979445648 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | skin 1; melanocytes[>=Low] |
| HPA:0340000 | 0.0467997293181 | 1.0 | DEK RTCB RTRAF DDX1 IFI16 PDAP1 GTPBP1 | ovary |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DDX1 | RTCB | 1.0 | 0.978 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | DDX1 | 1.0 | 0.97 |
mutually_exclusive (Q9Y3I0)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | RTCB | 0.996 | 0.92 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | IFI16 | 0.991 | 0.196 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTRAF | GTPBP1 | 0.99 | 0.192 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PDAP1 | RTRAF | 0.977 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| DEK | RTRAF | 0.976 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| DEK | RTCB | 0.97 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| IFI16 | RTCB | 0.895 | 0.388 | hein_WMM bioplex3_HEK293 bioplex3_WMM treiber_WMM WMM_only | |
| DDX1 | IFI16 | 0.857 | 0.338 | hein_WMM bioplex3_HEK293 bioplex3_WMM treiber_WMM WMM_only | |
| PDAP1 | IFI16 | 0.851 | 0.136 | hein_WMM bioplex3_HEK293 WMM_only | |
| GTPBP1 | RTCB | 0.756 | 0.154 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| DDX1 | GTPBP1 | 0.708 | 0.094 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| PDAP1 | DEK | 0.679 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DEK | DDX1 | 0.673 | 0.208 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DEK | IFI16 | 0.522 | 0.328666666667 | hein_WMM bioplex3_HEK293 WMM_only | |
| PDAP1 | RTCB | 0.498 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| PDAP1 | DDX1 | 0.268 | 0.074 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| DEK | GTPBP1 | 0.044 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PDAP1 | GTPBP1 | 0.018 | 0.076 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| IFI16 | GTPBP1 | 0.012 | 0.084 | WMM_only treiber_WMM |
Related Complexes