hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07789.1

Complex Portal: CPX-18593

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
FANCI	Fanconi anemia group I protein (Protein FACI)	5	UniProt NCBI
PRKDC	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)	5	UniProt NCBI
UMPS	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]	5	UniProt NCBI
NUP205	Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205)	5	UniProt NCBI
NUP93	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)	5	UniProt NCBI
UBE3C	Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)	5	UniProt NCBI
BSG	Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5619102	0.00038290615081	0.5	NUP205 BSG NUP93	SLC transporter disorders
REAC:R-HSA-5619115	0.00316393974757	0.5	NUP205 BSG NUP93	Disorders of transmembrane transporters
REAC:R-HSA-9615933	0.0070977267476	0.333333333333	NUP205 NUP93	Postmitotic nuclear pore complex (NPC) reformation
REAC:R-HSA-5619107	0.00971370123257	0.333333333333	NUP205 NUP93	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
REAC:R-HSA-170822	0.00971370123257	0.333333333333	NUP205 NUP93	Regulation of Glucokinase by Glucokinase Regulatory Protein
REAC:R-HSA-168274	0.0104313293282	0.333333333333	NUP205 NUP93	Export of Viral Ribonucleoproteins from Nucleus
REAC:R-HSA-168333	0.0104313293282	0.333333333333	NUP205 NUP93	NEP/NS2 Interacts with the Cellular Export Machinery
REAC:R-HSA-168271	0.0104313293282	0.333333333333	NUP205 NUP93	Transport of Ribonucleoproteins into the Host Nucleus
HP:0012588	0.011317974846	0.333333333333	NUP205 NUP93	Steroid-resistant nephrotic syndrome
REAC:R-HSA-180910	0.0119428487471	0.333333333333	NUP205 NUP93	Vpr-mediated nuclear import of PICs
REAC:R-HSA-180746	0.0119428487471	0.333333333333	NUP205 NUP93	Nuclear import of Rev protein
REAC:R-HSA-159227	0.0119428487471	0.333333333333	NUP205 NUP93	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-165054	0.0127367120473	0.333333333333	NUP205 NUP93	Rev-mediated nuclear export of HIV RNA
REAC:R-HSA-159230	0.0127367120473	0.333333333333	NUP205 NUP93	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-4085377	0.0127367120473	0.333333333333	NUP205 NUP93	SUMOylation of SUMOylation proteins
REAC:R-HSA-3301854	0.0135559590666	0.333333333333	NUP205 NUP93	Nuclear Pore Complex (NPC) Disassembly
REAC:R-HSA-176033	0.0144005758041	0.333333333333	NUP205 NUP93	Interactions of Vpr with host cellular proteins
REAC:R-HSA-177243	0.0144005758041	0.333333333333	NUP205 NUP93	Interactions of Rev with host cellular proteins
REAC:R-HSA-3232142	0.0152705482636	0.333333333333	NUP205 NUP93	SUMOylation of ubiquitinylation proteins
REAC:R-HSA-168276	0.0170865043842	0.333333333333	NUP205 NUP93	NS1 Mediated Effects on Host Pathways
REAC:R-HSA-159231	0.0180324600743	0.333333333333	NUP205 NUP93	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	0.019003715544	0.333333333333	NUP205 NUP93	Transport of Mature mRNAs Derived from Intronless Transcripts
REAC:R-HSA-168325	0.0200002568185	0.333333333333	NUP205 NUP93	Viral Messenger RNA Synthesis
REAC:R-HSA-4615885	0.0220691409046	0.333333333333	NUP205 NUP93	SUMOylation of DNA replication proteins
REAC:R-HSA-4570464	0.0231414557883	0.333333333333	NUP205 NUP93	SUMOylation of RNA binding proteins
REAC:R-HSA-2980766	0.0276828753036	0.333333333333	NUP205 NUP93	Nuclear Envelope Breakdown
WP:WP4016	0.0290813206156	0.333333333333	PRKDC FANCI	DNA IR damage and cellular response via ATR
HP:0031504	0.0297012565438	0.333333333333	NUP205 NUP93	Foamy urine
REAC:R-HSA-191859	0.0326270815028	0.333333333333	NUP205 NUP93	snRNP Assembly
REAC:R-HSA-194441	0.0326270815028	0.333333333333	NUP205 NUP93	Metabolism of non-coding RNA
WP:WP3998	0.0337850948883	0.333333333333	NUP205 NUP93	Prader Willi and Angelman syndrome
KEGG:03013	0.0360561963985	0.333333333333	NUP205 NUP93	Nucleocytoplasmic transport
REAC:R-HSA-6784531	0.0379731829042	0.333333333333	NUP205 NUP93	tRNA processing in the nucleus
HP:0012579	0.0436511011886	0.333333333333	NUP205 NUP93	Minimal change glomerulonephritis
CORUM:322	0.0499436884912	0.166666666667	PRKDC	DNA-PK-Ku complex
CORUM:355	0.0499436884912	0.166666666667	PRKDC	DNA-PK-Ku complex
CORUM:356	0.0499436884912	0.166666666667	PRKDC	DNA-PK-Ku complex
CORUM:357	0.0499436884912	0.166666666667	PRKDC	DNA-PK-Ku complex
CORUM:5182	0.0499436884912	0.166666666667	PRKDC	DNA-PK-Ku complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
NUP205	NUP93	0.999	0.944	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
BSG	FANCI	0.993	0.04	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
NUP205	BSG	0.992	0.122	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
UMPS	NUP93	0.986	0.236	hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only
PRKDC	FANCI	0.984	0.136	bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only
PRKDC	NUP93	0.983	0.552	bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only
PRKDC	UBE3C	0.979	0.238	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
UMPS	FANCI	0.976	0.15	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
PRKDC	BSG	0.975	0.164	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM
UMPS	NUP205	0.973	0.22	hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
NUP93	FANCI	0.972	0.288	bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only
PRKDC	NUP205	0.972	0.454	bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only
NUP205	UBE3C	0.964	0.242	bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only
UBE3C	FANCI	0.961	0.092	bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only
NUP205	FANCI	0.96	0.264	bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only
NUP93	UBE3C	0.943	0.202	bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only
UMPS	BSG	0.924	0.258	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM
NUP93	BSG	0.91	0.126	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM
BSG	UBE3C	0.862	0.038	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
UMPS	PRKDC	0.769	0.344	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM
UMPS	UBE3C	0.716	0.116	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only

Related Complexes

Genename	Complexes
FANCI	huMAP3_07170.1 huMAP3_07789.1 huMAP3_09042.1 huMAP3_09592.1
PRKDC	huMAP3_05673.1 huMAP3_07789.1 huMAP3_09042.1 huMAP3_09592.1
UMPS	huMAP3_01554.1 huMAP3_07170.1 huMAP3_07670.1 huMAP3_07789.1 huMAP3_09042.1 huMAP3_10240.1 huMAP3_12841.1
NUP205	huMAP3_05673.1 huMAP3_06791.1 huMAP3_07789.1 huMAP3_08311.1 huMAP3_09042.1
NUP93	huMAP3_05673.1 huMAP3_07789.1 huMAP3_09042.1
UBE3C	huMAP3_06247.1 huMAP3_07789.1 huMAP3_08167.1 huMAP3_09042.1 huMAP3_09592.1
BSG	huMAP3_05673.1 huMAP3_07789.1 huMAP3_09042.1 huMAP3_12623.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07789.1

Complex Portal: CPX-18593