hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07806.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM106C | Transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer) | 5 | UniProt NCBI |
| HLA-G | HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)] | 5 | UniProt NCBI |
| HLA-A | HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A) | 5 | UniProt NCBI |
| HLA-C | HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C) | 5 | UniProt NCBI |
| NCSTN | Nicastrin | 5 | UniProt NCBI |
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1) | 5 | UniProt NCBI |
| M6PR | Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) | 5 | UniProt NCBI |
| SCARB1 | Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) | 5 | UniProt NCBI |
| LMF1 | Lipase maturation factor 1 (Transmembrane protein 112) | 5 | UniProt NCBI |
| TMEM30A | Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) | 5 | UniProt NCBI |
| TMEM106B | Transmembrane protein 106B | 5 | UniProt NCBI |
| CNNM3 | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05330 | 3.3684094287e-05 | 0.3 | HLA-G HLA-DRB1 HLA-A | Allograft rejection |
| KEGG:05332 | 5.16896915966e-05 | 0.3 | HLA-G HLA-DRB1 HLA-A | Graft-versus-host disease |
| KEGG:04145 | 6.44593178058e-05 | 0.4 | HLA-G SCARB1 HLA-DRB1 HLA-A | Phagosome |
| KEGG:04940 | 7.51552043595e-05 | 0.3 | HLA-G HLA-DRB1 HLA-A | Type I diabetes mellitus |
| KEGG:05320 | 0.000113246607598 | 0.3 | HLA-G HLA-DRB1 HLA-A | Autoimmune thyroid disease |
| KEGG:05416 | 0.000282879916312 | 0.3 | HLA-G HLA-DRB1 HLA-A | Viral myocarditis |
| KEGG:04612 | 0.000409418963662 | 0.3 | HLA-G HLA-DRB1 HLA-A | Antigen processing and presentation |
| WP:WP2328 | 0.00106295369076 | 0.3 | HLA-G HLA-DRB1 HLA-A | Allograft rejection |
| KEGG:04514 | 0.00203975695512 | 0.3 | HLA-G HLA-DRB1 HLA-A | Cell adhesion molecules |
| GO:0098581 | 0.00328700479383 | 0.3 | HLA-A HLA-DRB1 SCARB1 | detection of external biotic stimulus |
| REAC:R-HSA-877300 | 0.00381570377755 | 0.3 | HLA-G HLA-DRB1 HLA-A | Interferon gamma signaling |
| WP:WP4217 | 0.00552554320282 | 0.3 | HLA-G HLA-DRB1 HLA-A | Ebola virus infection in host |
| REAC:R-HSA-1236977 | 0.00557969031297 | 0.2 | HLA-G HLA-A | Endosomal/Vacuolar pathway |
| WP:WP4585 | 0.00704825789595 | 0.2 | HLA-A HLA-DRB1 | Cancer immunotherapy by PD 1 blockade |
| GO:0009595 | 0.00936146543831 | 0.3 | HLA-A HLA-DRB1 SCARB1 | detection of biotic stimulus |
| KEGG:05169 | 0.0104169791335 | 0.3 | HLA-G HLA-DRB1 HLA-A | Epstein-Barr virus infection |
| GO:0002483 | 0.0130691170406 | 0.3 | HLA-G HLA-DRB1 HLA-A | antigen processing and presentation of endogenous peptide antigen |
| KEGG:05166 | 0.0137961719519 | 0.3 | HLA-G HLA-DRB1 HLA-A | Human T-cell leukemia virus 1 infection |
| GO:0098553 | 0.0176420810956 | 0.3 | HLA-G HLA-DRB1 HLA-A | lumenal side of endoplasmic reticulum membrane |
| GO:0019883 | 0.0231700664584 | 0.3 | HLA-G HLA-DRB1 HLA-A | antigen processing and presentation of endogenous antigen |
| HP:0100699 | 0.0249015500331 | 0.3 | HLA-A HLA-DRB1 NCSTN | Scarring |
| GO:0042605 | 0.0263201547963 | 0.3 | HLA-G HLA-DRB1 HLA-A | peptide antigen binding |
| REAC:R-HSA-983170 | 0.0354011801879 | 0.2 | HLA-G HLA-A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-913531 | 0.0459825497062 | 0.3 | HLA-G HLA-DRB1 HLA-A | Interferon Signaling |
| GO:0001916 | 0.0463773280544 | 0.3 | HLA-G HLA-DRB1 HLA-A | positive regulation of T cell mediated cytotoxicity |
| GO:0098576 | 0.0463773280544 | 0.3 | HLA-G HLA-DRB1 HLA-A | lumenal side of membrane |
| WP:WP5362 | 0.0479442074014 | 0.2 | HLA-G HLA-A | TAR syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| HLA-C | HLA-A | 0.999 | 0.566 |
| HLA-C | CNNM3 | 0.997 | 0.116 |
| HLA-C | NCSTN | 0.996 | 0.164 |
| HLA-C | TMEM30A | 0.996 | 0.13046969697 |
| HLA-C | LMF1 | 0.995 | 0.154 |
| HLA-C | TMEM106B | 0.994 | 0.0745 |
| HLA-A | TMEM30A | 0.992 | 0.124 |
| M6PR | HLA-C | 0.991 | 0.236 |
| HLA-G | HLA-A | 0.99 | 0.674 |
| TMEM106C | HLA-C | 0.99 | |
| TMEM30A | CNNM3 | 0.987 | 0.07 |
| SCARB1 | TMEM30A | 0.986 | 0.046 |
| HLA-G | HLA-C | 0.985 | 0.446 |
| NCSTN | TMEM30A | 0.985 | 0.088 |
| HLA-G | TMEM106B | 0.985 | 0.026 |
| HLA-DRB1 | HLA-C | 0.984 | 0.36 |
| LMF1 | TMEM30A | 0.983 | 0.062 |
| HLA-G | LMF1 | 0.983 | 0.164 |
| TMEM106C | TMEM30A | 0.982 | |
| HLA-DRB1 | TMEM106B | 0.979 | 0.042 |
| TMEM30A | TMEM106B | 0.978 | 0.042 |
| HLA-G | TMEM30A | 0.976 | 0.076 |
| HLA-DRB1 | SCARB1 | 0.976 | 0.068 |
| HLA-A | CNNM3 | 0.975 | 0.086 |
| HLA-DRB1 | CNNM3 | 0.974 | 0.133134328358 |
| M6PR | CNNM3 | 0.974 | 0.06 |
| HLA-A | NCSTN | 0.972 | 0.136 |
| HLA-C | SCARB1 | 0.968 | 0.14646969697 |
| M6PR | TMEM30A | 0.968 | 0.07 |
| SCARB1 | CNNM3 | 0.967 | 0.034 |
| NCSTN | CNNM3 | 0.965 | 0.078 |
| HLA-A | SCARB1 | 0.962 | 0.124 |
| TMEM106C | TMEM106B | 0.96 | |
| M6PR | TMEM106B | 0.952 | 0.186 |
| HLA-DRB1 | NCSTN | 0.951 | 0.158474226804 |
| HLA-G | CNNM3 | 0.95 | 0.0983928571429 |
| M6PR | SCARB1 | 0.947 | 0.076 |
| NCSTN | TMEM106B | 0.93 | 0.254 |
| HLA-G | NCSTN | 0.929 | 0.206 |
| HLA-G | SCARB1 | 0.928 | 0.064 |
| TMEM106C | HLA-DRB1 | 0.92 | |
| M6PR | HLA-DRB1 | 0.917 | 0.148474226804 |
| M6PR | HLA-A | 0.911 | 0.062 |
| TMEM106C | SCARB1 | 0.907 | |
| SCARB1 | TMEM106B | 0.904 | 0.098 |
| HLA-A | TMEM106B | 0.897 | 0.086 |
| HLA-G | M6PR | 0.886 | 0.112 |
| HLA-DRB1 | HLA-A | 0.878 | 0.296 |
| NCSTN | SCARB1 | 0.869 | 0.074 |
| M6PR | TMEM106C | 0.767 | |
| TMEM106C | CNNM3 | 0.742 | |
| TMEM106B | CNNM3 | 0.702 | 0.038 |
| LMF1 | CNNM3 | 0.693 | 0.092 |
| HLA-DRB1 | TMEM30A | 0.689 | 0.08 |
| SCARB1 | LMF1 | 0.688 | 0.052 |
| TMEM106C | NCSTN | 0.599 | |
| TMEM106C | LMF1 | 0.54 | |
| M6PR | NCSTN | 0.533 | 0.126 |
| HLA-A | LMF1 | 0.525 | 0.182 |
| HLA-G | HLA-DRB1 | 0.52 | 0.414 |
| LMF1 | TMEM106B | 0.517 | 0.0480677966102 |
| HLA-G | TMEM106C | 0.463 | |
| HLA-DRB1 | LMF1 | 0.435 | |
| NCSTN | LMF1 | 0.422 | 0.092 |
| M6PR | LMF1 | 0.419 | 0.032 |
| TMEM106C | HLA-A | 0.374 |
Related Complexes
| Genename | Complexes |
|---|---|
| TMEM106C | huMAP3_02522.1 huMAP3_07806.1 huMAP3_09398.1 huMAP3_11677.1 |
| HLA-G | huMAP3_01561.1 huMAP3_07806.1 huMAP3_09398.1 huMAP3_09776.1 |
| HLA-A | huMAP3_07806.1 huMAP3_09398.1 |
| HLA-C | huMAP3_06634.1 huMAP3_07785.1 huMAP3_07806.1 huMAP3_09398.1 |
| NCSTN | huMAP3_07806.1 huMAP3_09398.1 |
| HLA-DRB1 | huMAP3_05213.1 huMAP3_05482.1 huMAP3_07806.1 huMAP3_09398.1 huMAP3_09938.1 |
| M6PR | huMAP3_02161.1 huMAP3_07806.1 huMAP3_09398.1 |
| SCARB1 | huMAP3_07806.1 huMAP3_09398.1 |
| LMF1 | huMAP3_07806.1 huMAP3_09398.1 huMAP3_14123.1 |
| TMEM30A | huMAP3_07806.1 huMAP3_09398.1 |
| TMEM106B | huMAP3_07806.1 huMAP3_09398.1 huMAP3_11677.1 |
| CNNM3 | huMAP3_07806.1 huMAP3_09398.1 |