hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07836.1

Complex Portal: CPX-24109

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
ANXA2	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	5	UniProt NCBI
GNAS	Protein ALEX (Alternative gene product encoded by XL-exon)	5	UniProt NCBI
RAP2C	Ras-related protein Rap-2c (EC 3.6.5.2)	5	UniProt NCBI
RAB1A	Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein)	5	UniProt NCBI
ACTN1	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	5	UniProt NCBI
RAC3	Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)	5	UniProt NCBI
RAP1A	Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)	5	UniProt NCBI
RRAS2	Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene)	5	UniProt NCBI
RAP1B	Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0003924	6.69009408827e-06	0.857142857143	RRAS2 RAC3 RAB1A RAP1A RAP1B RAP2C	GTPase activity
KEGG:04024	2.34228321686e-05	0.571428571429	RAP1A RAP1B RAC3 RRAS2	cAMP signaling pathway
WP:WP4223	3.04259486425e-05	0.571428571429	RAP1A RAP1B RAC3 RRAS2	Ras signaling
KEGG:04014	4.31295286347e-05	0.571428571429	RAP1A RAP1B RAC3 RRAS2	Ras signaling pathway
GO:0017111	7.98536289713e-05	0.857142857143	RRAS2 RAC3 RAB1A RAP1A RAP1B RAP2C	ribonucleoside triphosphate phosphatase activity
WP:WP382	0.000106586503568	0.571428571429	RAP1A RAP1B RAC3 RRAS2	MAPK signaling pathway
KEGG:04010	0.000130964006708	0.571428571429	RAP1A RAP1B RAC3 RRAS2	MAPK signaling pathway
GO:0016817	0.000160710926303	0.857142857143	RRAS2 RAC3 RAB1A RAP1A RAP1B RAP2C	hydrolase activity, acting on acid anhydrides
GO:0016818	0.000160710926303	0.857142857143	RRAS2 RAC3 RAB1A RAP1A RAP1B RAP2C	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016462	0.000160710926303	0.857142857143	RRAS2 RAC3 RAB1A RAP1A RAP1B RAP2C	pyrophosphatase activity
GO:0005525	0.000239435127266	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	GTP binding
KEGG:04520	0.000353303499329	0.428571428571	RAP1A RAC3 RAP1B	Adherens junction
GO:0032561	0.000423574606398	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	guanyl ribonucleotide binding
GO:0019001	0.000434555086478	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	guanyl nucleotide binding
GO:0019003	0.000543274134751	0.571428571429	RAP1A RAP1B RAP2C RRAS2	GDP binding
WP:WP185	0.000571120678644	0.428571428571	RAP1A RAC3 RAP1B	Integrin mediated cell adhesion
GO:0032486	0.000738757615619	0.428571428571	RAP1A RAP2C RAP1B	Rap protein signal transduction
KEGG:04062	0.00149560971039	0.428571428571	RAP1A RAC3 RAP1B	Chemokine signaling pathway
REAC:R-HSA-8875555	0.00171179400053	0.285714285714	RAP1A RAP1B	MET activates RAP1 and RAC1
REAC:R-HSA-354194	0.00209171533568	0.285714285714	RAP1A RAP1B	GRB2:SOS provides linkage to MAPK signaling for Integrins
REAC:R-HSA-372708	0.00250948572249	0.285714285714	RAP1A RAP1B	p130Cas linkage to MAPK signaling for integrins
KEGG:04015	0.00254224388429	0.428571428571	RAP1A RAC3 RAP1B	Rap1 signaling pathway
KEGG:04510	0.00287556705452	0.428571428571	RAP1A RAC3 RAP1B	Focal adhesion
WP:WP1981	0.00303405736115	0.285714285714	RAP1A RAP1B	Thyroxine thyroid hormone production
REAC:R-HSA-392517	0.00345846977329	0.285714285714	RAP1A RAP1B	Rap1 signalling
GO:0007264	0.00442466612135	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	small GTPase-mediated signal transduction
REAC:R-HSA-6798695	0.00462905575557	0.571428571429	ANXA2 RAP1B RAP2C RAP1A	Neutrophil degranulation
WP:WP306	0.00499056746055	0.428571428571	RAP1A RAC3 RAP1B	Focal adhesion
WP:WP313	0.00769886208303	0.285714285714	RAP1A RAP1B	Hepatocyte growth factor receptor signaling
REAC:R-HSA-354192	0.00796834465067	0.285714285714	RAP1A RAP1B	Integrin signaling
WP:WP2636	0.00877446561805	0.285714285714	RAP1A RAP1B	Common pathways underlying drug addiction
GO:0043168	0.00942719164675	0.857142857143	RRAS2 ANXA2 RAC3 RAP1A RAP1B RAP2C	anion binding
REAC:R-HSA-76009	0.0143201223364	0.285714285714	RAP1A RAP1B	Platelet Aggregation (Plug Formation)
KEGG:04720	0.0145134445639	0.285714285714	RAP1A RAP1B	Long-term potentiation
REAC:R-HSA-6802948	0.0164719839916	0.285714285714	RAP1A RAP1B	Signaling by high-kinase activity BRAF mutants
GO:0035639	0.0184957282357	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	purine ribonucleoside triphosphate binding
GO:0061028	0.0200035679209	0.428571428571	RAP1A RAP2C RAP1B	establishment of endothelial barrier
KEGG:05211	0.0210427715268	0.285714285714	RAP1A RAP1B	Renal cell carcinoma
REAC:R-HSA-5674135	0.0212237900738	0.285714285714	RAP1A RAP1B	MAP2K and MAPK activation
REAC:R-HSA-8875878	0.0212237900738	0.285714285714	RAP1A RAP1B	MET promotes cell motility
REAC:R-HSA-9656223	0.0225049419259	0.285714285714	RAP1A RAP1B	Signaling by RAF1 mutants
GO:0070062	0.0239791568402	1.0	RAP1B ANXA2 RAP2C RAB1A RRAS2 RAP1A RAC3	extracellular exosome
REAC:R-HSA-8950505	0.0251789059	0.285714285714	ANXA2 RAP1B	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
GO:1903561	0.0255843975786	1.0	RAP1B ANXA2 RAP2C RAB1A RRAS2 RAP1A RAC3	extracellular vesicle
GO:0065010	0.0256816238452	1.0	RAP1B ANXA2 RAP2C RAB1A RRAS2 RAP1A RAC3	extracellular membrane-bounded organelle
GO:0043230	0.0256816238452	1.0	RAP1B ANXA2 RAP2C RAB1A RRAS2 RAP1A RAC3	extracellular organelle
KEGG:04972	0.0258170059595	0.285714285714	RAP1A RAP1B	Pancreatic secretion
GO:0001885	0.0259578682575	0.428571428571	RAP1A RAP2C RAP1B	endothelial cell development
WP:WP2032	0.0261327164033	0.285714285714	RAP1A RAP1B	Thyroid stimulating hormone TSH signaling pathway
REAC:R-HSA-6802955	0.0265716665994	0.285714285714	RAP1A RAP1B	Paradoxical activation of RAF signaling by kinase inactive BRAF
REAC:R-HSA-6802949	0.0265716665994	0.285714285714	RAP1A RAP1B	Signaling by RAS mutants
REAC:R-HSA-6802946	0.0265716665994	0.285714285714	RAP1A RAP1B	Signaling by moderate kinase activity BRAF mutants
REAC:R-HSA-9649948	0.0265716665994	0.285714285714	RAP1A RAP1B	Signaling downstream of RAS mutants
WP:WP4205	0.028073243565	0.285714285714	RAP1A RAP1B	MET in type 1 papillary renal cell carcinoma
GO:2000301	0.0294899169624	0.285714285714	RAP1A RAP1B	negative regulation of synaptic vesicle exocytosis
GO:0032555	0.034966258944	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	purine ribonucleotide binding
REAC:R-HSA-9020591	0.0357075146256	0.285714285714	ANXA2 RAP1B	Interleukin-12 signaling
KEGG:04670	0.0367995848147	0.285714285714	RAP1A RAP1B	Leukocyte transendothelial migration
GO:0032553	0.0379960692701	0.714285714286	RAP1A RAP1B RAP2C RRAS2 RAC3	ribonucleotide binding
MIRNA:hsa-miR-19a-3p	0.0455788545964	0.714285714286	RAB1A RAP1B RAP2C RRAS2 RAP1A	hsa-miR-19a-3p
KEGG:04611	0.047723469919	0.285714285714	RAP1A RAP1B	Platelet activation
KEGG:04722	0.0496787672026	0.285714285714	RAP1A RAP1B	Neurotrophin signaling pathway

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RRAS2	RAP2C	0.993	0.078		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
GNAS	RRAS2	0.993			hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RRAS2	RAP1B	0.992	0.094		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ANXA2	RAP1A	0.992	0.12		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
RRAS2	RAP1A	0.99	0.1		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
GNAS	RAP1A	0.988			hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
RAC3	RAP1A	0.988	0.086		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RRAS2	ANXA2	0.982	0.148		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAP2C	RAP1A	0.973	0.126		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
RAB1A	RAC3	0.972	0.188		hein_WMM bioplex3_WMM WMM_only
RAP1B	RAP1A	0.97	0.882		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
RAC3	RRAS2	0.969	0.154333988212		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ACTN1	RAP1A	0.967	0.144		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RRAS2	ACTN1	0.966	0.076		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RAC3	RAP1B	0.961	0.0863339882122	mutually_exclusive (P52306)	hein_WMM bioplex_WMM bioplex3_WMM fraction
RAC3	RAP2C	0.961	0.038		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
GNAS	RAB1A	0.961			hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
RAB1A	RRAS2	0.961	0.268		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
GNAS	RAP1B	0.957			hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
GNAS	ANXA2	0.953			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
RAB1A	RAP1A	0.951	0.676		hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
RAB1A	RAP2C	0.946	0.164	structurally_consistent (dimer)	hein_WMM bioplex_WMM Guru bioplex3_WMM fraction
RAB1A	RAP1B	0.926	0.478		hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
RAB1A	ANXA2	0.92	0.186		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM
RAP2C	RAP1B	0.915	0.106		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
GNAS	RAC3	0.784			hein_WMM bioplex3_WMM WMM_only
RAC3	ANXA2	0.784	0.092		hein_WMM bioplex3_WMM WMM_only
ANXA2	RAP1B	0.703	0.104		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM
ACTN1	ANXA2	0.571	0.722		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
GNAS	RAP2C	0.446			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
GNAS	ACTN1	0.276			hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
RAP2C	ANXA2	0.251	0.024		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM
RAB1A	ACTN1	0.118	0.246		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
ACTN1	RAP1B	0.066	0.24		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAP2C	ACTN1	0.011	0.0721855670103		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
RAC3	ACTN1	0.008	0.116		hein_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
ANXA2	huMAP3_05674.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_13705.1 huMAP3_15218.1
GNAS	huMAP3_00249.1 huMAP3_05674.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_11173.1 huMAP3_12729.1
RAP2C	huMAP3_03804.1 huMAP3_06179.1 huMAP3_06512.1 huMAP3_07045.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_11118.1
RAB1A	huMAP3_01895.1 huMAP3_02945.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_08941.1 huMAP3_09165.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11118.1
ACTN1	huMAP3_05633.1 huMAP3_05719.1 huMAP3_07836.1 huMAP3_09165.1
RAC3	huMAP3_03705.1 huMAP3_05480.1 huMAP3_06179.1 huMAP3_06217.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
RAP1A	huMAP3_06179.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1 huMAP3_11897.1 huMAP3_14124.1
RRAS2	huMAP3_03705.1 huMAP3_05633.1 huMAP3_06179.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
RAP1B	huMAP3_05674.1 huMAP3_06217.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07836.1

Complex Portal: CPX-24109