hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07838.1

Complex Portal: CPX-24180

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PLEKHA7	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	5	UniProt NCBI
HIVEP1	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	5	UniProt NCBI
TIAM1	Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)	5	UniProt NCBI
PI4KB	Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)	5	UniProt NCBI
YWHAQ	14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)	5	UniProt NCBI
DENND4A	C-myc promoter-binding protein (DENN domain-containing protein 4A)	5	UniProt NCBI
PACS2	Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)	5	UniProt NCBI
SAMD4A	Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)	5	UniProt NCBI
SRGAP1	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)	5	UniProt NCBI
CDC25B	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	5	UniProt NCBI
IRS2	Insulin receptor substrate 2 (IRS-2)	5	UniProt NCBI
SPATA13	Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)	5	UniProt NCBI
SPIRE2	Protein spire homolog 2 (Spir-2)	5	UniProt NCBI
HECTD4	HECT domain E3 ubiquitin protein ligase 4	1	UniProt NCBI
SASH1	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)	5	UniProt NCBI
SAMD4B	Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)	5	UniProt NCBI
FOXO3	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	5	UniProt NCBI
DMTN	Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9)	5	UniProt NCBI
TBC1D1	TBC1 domain family member 1	5	UniProt NCBI
LNP1	Leukemia NUP98 fusion partner 1	2	UniProt NCBI
PTOV1	Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)	5	UniProt NCBI
ANKRD34A	Ankyrin repeat domain-containing protein 34A	3	UniProt NCBI
BRAF	Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)	5	UniProt NCBI
PTPN3	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	5	UniProt NCBI
KIAA0930	Uncharacterized protein KIAA0930	3	UniProt NCBI
YWHAB	14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]	5	UniProt NCBI
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	5	UniProt NCBI
ZNF395	Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor)	5	UniProt NCBI
SFN	14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)	5	UniProt NCBI
SPIRE1	Protein spire homolog 1 (Spir-1)	5	UniProt NCBI
FAM53B	Protein FAM53B (Protein simplet)	5	UniProt NCBI
BAD	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	5	UniProt NCBI
YWHAE	14-3-3 protein epsilon (14-3-3E)	5	UniProt NCBI
SH3RF3	E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)	5	UniProt NCBI
HDAC5	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)	5	UniProt NCBI
CRTC1	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	5	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
ERRFI1	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)	5	UniProt NCBI
FOXO1	Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)	5	UniProt NCBI
HDAC4	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	5	UniProt NCBI
YWHAG	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	5	UniProt NCBI
SRGAP2	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)	5	UniProt NCBI
A0A1X9RU27		None	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9614399	1.47436992402e-13	0.179487179487	YWHAB FOXO3 FOXO1 A0A1X9RU27 SFN YWHAQ YWHAG	Regulation of localization of FOXO transcription factors
REAC:R-HSA-111447	4.09244220582e-10	0.153846153846	YWHAB SFN BAD YWHAQ YWHAE YWHAG	Activation of BAD and translocation to mitochondria
REAC:R-HSA-9755779	2.79350428673e-08	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	SARS-CoV-2 targets host intracellular signalling and regulatory pathways
REAC:R-HSA-75035	4.53064088427e-08	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REAC:R-HSA-114452	4.71597116577e-08	0.153846153846	YWHAB SFN BAD YWHAQ YWHAE YWHAG	Activation of BH3-only proteins
REAC:R-HSA-9614085	6.55649312745e-08	0.179487179487	YWHAB FOXO3 FOXO1 A0A1X9RU27 SFN YWHAQ YWHAG	FOXO-mediated transcription
REAC:R-HSA-9735871	1.05305312729e-07	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	SARS-CoV-1 targets host intracellular signalling and regulatory pathways
REAC:R-HSA-109606	1.54940892268e-06	0.153846153846	YWHAB SFN BAD YWHAQ YWHAE YWHAG	Intrinsic Pathway for Apoptosis
REAC:R-HSA-1445148	8.82742584692e-06	0.153846153846	YWHAB TBC1D1 SFN YWHAE YWHAQ YWHAG	Translocation of SLC2A4 (GLUT4) to the plasma membrane
CORUM:5199	1.37474868781e-05	0.102564102564	YWHAQ YWHAE YWHAG YWHAB	Kinase maturation complex 1
WP:WP5376	2.70448566086e-05	0.102564102564	YWHAQ YWHAE YWHAG YWHAB	17p13 3 YWHAE copy number variation
KEGG:05203	3.42367518135e-05	0.179487179487	YWHAB HDAC5 BAD HDAC4 YWHAQ YWHAE YWHAG	Viral carcinogenesis
WP:WP4542	0.000130310298606	0.102564102564	YWHAQ A0A1X9RU27 FOXO1 FOXO3	Leukocyte intrinsic Hippo pathway functions
REAC:R-HSA-5674400	0.000181358411249	0.102564102564	FOXO3 A0A1X9RU27 FOXO1 BAD	Constitutive Signaling by AKT1 E17K in Cancer
TF:M00800_1	0.000553011174311	0.666666666667	SH3RF3 TBC1D1 HDAC5 CRTC1 PTOV1 YWHAQ PARD3 DENND4A ERRFI1 SAMD4B PACS2 FOXO1 SAMD4A HDAC4 SRGAP1 SRGAP2 IRS2 ZNF395 SPIRE2 SPIRE1 SASH1 PLEKHA7 BAD A0A1X9RU27 FAM53B FOXO3	Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1
REAC:R-HSA-2219528	0.00057549915561	0.128205128205	IRS2 BAD A0A1X9RU27 FOXO1 FOXO3	PI3K/AKT Signaling in Cancer
REAC:R-HSA-5628897	0.00069797605138	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	TP53 Regulates Metabolic Genes
REAC:R-HSA-198693	0.000717636336206	0.0769230769231	FOXO3 A0A1X9RU27 FOXO1	AKT phosphorylates targets in the nucleus
KEGG:04152	0.000767300557631	0.128205128205	TBC1D1 IRS2 PFKFB2 FOXO1 FOXO3	AMPK signaling pathway
REAC:R-HSA-5625740	0.000790413459773	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	RHO GTPases activate PKNs
GO:0045936	0.000934429979265	0.230769230769	YWHAB ERRFI1 DMTN IRS2 YWHAG HDAC4 SFN YWHAE PARD3	negative regulation of phosphate metabolic process
GO:0010563	0.000966395688661	0.230769230769	YWHAB ERRFI1 DMTN IRS2 YWHAG HDAC4 SFN YWHAE PARD3	negative regulation of phosphorus metabolic process
REAC:R-HSA-69473	0.00112668331545	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	G2/M DNA damage checkpoint
WP:WP536	0.00150276993564	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	Calcium regulation in cardiac cells
REAC:R-HSA-9692914	0.00156636682845	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	SARS-CoV-1-host interactions
KEGG:05160	0.00157096976584	0.128205128205	YWHAE YWHAQ BAD YWHAG YWHAB	Hepatitis C
REAC:R-HSA-109581	0.00161777837351	0.153846153846	YWHAB SFN BAD YWHAQ YWHAE YWHAG	Apoptosis
REAC:R-HSA-5663202	0.00170373741509	0.205128205128	YWHAB IRS2 HDAC5 FOXO1 BAD A0A1X9RU27 FOXO3 HDAC4	Diseases of signal transduction by growth factor receptors and second messengers
WP:WP179	0.00178276047899	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	Cell cycle
REAC:R-HSA-162582	0.00200406538565	0.435897435897	YWHAB YWHAQ SRGAP2 FOXO3 TIAM1 SFN YWHAE HDAC5 FOXO1 SPATA13 A0A1X9RU27 IRS2 SRGAP1 BAD PARD3 YWHAG HDAC4	Signal Transduction
WP:WP2380	0.00236925687863	0.128205128205	TIAM1 BAD CRTC1 FOXO3 IRS2	Brain derived neurotrophic factor BDNF signaling pathway
KEGG:04390	0.00264490527504	0.128205128205	YWHAQ YWHAE PARD3 YWHAG YWHAB	Hippo signaling pathway
KEGG:04110	0.00310684923876	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	Cell cycle
WP:WP289	0.00321296742002	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	Myometrial relaxation and contraction pathways
REAC:R-HSA-5357801	0.00395570773295	0.153846153846	YWHAB SFN BAD YWHAQ YWHAE YWHAG	Programmed Cell Death
TF:M00982_1	0.00582743137337	0.589743589744	SH3RF3 TBC1D1 CRTC1 PTOV1 YWHAQ PARD3 DENND4A SAMD4B PACS2 FOXO1 SAMD4A HDAC4 IRS2 YWHAG PFKFB2 ZNF395 FOXO3 SPIRE2 SPIRE1 PLEKHA7 BAD A0A1X9RU27 YWHAE	Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1
WP:WP3932	0.00609708763617	0.153846153846	TBC1D1 PFKFB2 FOXO1 BAD IRS2 FOXO3	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04151	0.0065657753328	0.153846153846	YWHAB FOXO3 BAD YWHAQ YWHAE YWHAG	PI3K-Akt signaling pathway
GO:0005829	0.0070687306874	0.717948717949	DMTN TIAM1 HDAC5 PI4KB CRTC1 YWHAQ PARD3 DENND4A ERRFI1 BAD FOXO1 SAMD4A HDAC4 PFKFB2 SRGAP1 YWHAG YWHAB SRGAP2 IRS2 ZNF395 FOXO3 SFN SPIRE1 SPATA13 SASH1 PLEKHA7 SAMD4B YWHAE	cytosol
REAC:R-HSA-9678108	0.00864277503	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	SARS-CoV-1 Infection
TF:M09723_1	0.00888375169216	0.74358974359	DMTN TBC1D1 HDAC5 CRTC1 PTOV1 YWHAQ PARD3 DENND4A ERRFI1 SAMD4B PACS2 FOXO1 SAMD4A HDAC4 IRS2 YWHAG YWHAB SRGAP2 SPIRE1 PFKFB2 ZNF395 YWHAE SPIRE2 HECTD4 FAM53B PLEKHA7 BAD A0A1X9RU27 FOXO3	Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1
WP:WP3844	0.00902366931082	0.0769230769231	FOXO3 FOXO1 BAD	PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer
REAC:R-HSA-1257604	0.0103686356256	0.153846153846	IRS2 HDAC5 FOXO1 BAD A0A1X9RU27 FOXO3	PIP3 activates AKT signaling
KEGG:04114	0.0106845243229	0.102564102564	YWHAQ YWHAE YWHAG YWHAB	Oocyte meiosis
REAC:R-HSA-194315	0.011096335013	0.230769230769	YWHAB YWHAQ SRGAP2 TIAM1 YWHAE SPATA13 SRGAP1 SFN YWHAG	Signaling by Rho GTPases
TF:M03893_1	0.0121841130443	0.615384615385	SH3RF3 TBC1D1 CRTC1 PTOV1 YWHAQ PARD3 DENND4A ERRFI1 SAMD4B PACS2 SAMD4A HDAC4 IRS2 YWHAG SPIRE1 PFKFB2 ZNF395 SPIRE2 HECTD4 SASH1 PLEKHA7 BAD A0A1X9RU27 YWHAE	Factor: WT1; motif: GNGGGGGCGGGG; match class: 1
REAC:R-HSA-9716542	0.0131851643747	0.230769230769	YWHAB YWHAQ SRGAP2 TIAM1 YWHAE SPATA13 SRGAP1 SFN YWHAG	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
REAC:R-HSA-9615017	0.0133787103715	0.0769230769231	FOXO3 A0A1X9RU27 FOXO1	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
KEGG:04068	0.0147061033179	0.102564102564	IRS2 A0A1X9RU27 FOXO1 FOXO3	FoxO signaling pathway
TF:M02281_1	0.0185393234986	0.487179487179	HECTD4 SRGAP2 SPIRE2 SAMD4B TBC1D1 PACS2 PFKFB2 FAM53B PLEKHA7 PI4KB FOXO3 ZNF395 A0A1X9RU27 IRS2 YWHAQ PTOV1 BAD YWHAG CRTC1	Factor: SP1; motif: CCCCKCCCCC; match class: 1
REAC:R-HSA-69481	0.0210722082871	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	G2/M Checkpoints
REAC:R-HSA-9006925	0.0228585273239	0.153846153846	IRS2 HDAC5 FOXO1 BAD A0A1X9RU27 FOXO3	Intracellular signaling by second messengers
WP:WP286	0.02495641489	0.0769230769231	YWHAQ BAD YWHAB	IL 3 signaling pathway
KEGG:04213	0.0257878424281	0.0769230769231	IRS2 FOXO1 FOXO3	Longevity regulating pathway - multiple species
KEGG:04062	0.0323629297496	0.102564102564	TIAM1 BAD PARD3 FOXO3	Chemokine signaling pathway
TF:M13144_1	0.0333392047091	0.692307692308	SH3RF3 TBC1D1 HDAC5 PI4KB CRTC1 PTOV1 YWHAQ PARD3 DENND4A ERRFI1 FOXO1 SAMD4A HDAC4 SRGAP1 YWHAG YWHAB SPIRE1 IRS2 ZNF395 KIAA0930 SPIRE2 HECTD4 FAM53B PLEKHA7 BAD A0A1X9RU27 SASH1	Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS; match class: 1
HPA:0460671	0.0356478731409	0.615384615385	SH3RF3 TBC1D1 HDAC5 PI4KB CRTC1 PTOV1 YWHAQ PARD3 DENND4A BAD FOXO1 SAMD4A HDAC4 TIAM1 YWHAG YWHAB SRGAP2 SPATA13 YWHAE SFN FAM53B PLEKHA7 SAMD4B FOXO3	skin 1; melanocytes[>=Low]
WP:WP706	0.0390817879697	0.102564102564	YWHAQ YWHAE YWHAG YWHAB	Sudden infant death syndrome SIDS susceptibility pathways
WP:WP3630	0.0409645888725	0.0512820512821	FOXO3 FOXO1	NAD metabolism sirtuins and aging
REAC:R-HSA-195258	0.0420457030474	0.153846153846	YWHAB SRGAP2 YWHAE SFN YWHAQ YWHAG	RHO GTPase Effectors
TF:M00982	0.0435328982239	0.820512820513	SH3RF3 TBC1D1 HDAC5 PI4KB CRTC1 SPIRE2 YWHAQ PARD3 DENND4A ERRFI1 BAD PTOV1 PACS2 FOXO1 SAMD4A HDAC4 IRS2 YWHAG SRGAP2 SPIRE1 PFKFB2 ZNF395 YWHAE SFN HECTD4 LNP1 FAM53B PLEKHA7 SAMD4B A0A1X9RU27 SASH1 FOXO3	Factor: KROX; motif: CCCGCCCCCRCCCC
REAC:R-HSA-9705683	0.0464891768456	0.128205128205	YWHAQ SFN YWHAE YWHAG YWHAB	SARS-CoV-2-host interactions

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
YWHAG	YWHAB	1.0	0.913
YWHAG	YWHAE	1.0	0.782
YWHAB	YWHAE	1.0	0.704
YWHAQ	YWHAB	0.999	0.572	structurally_consistent (dimer)
YWHAG	FAM53B	0.999
YWHAG	YWHAQ	0.999	0.77	structurally_consistent (dimer)
YWHAG	SAMD4A	0.999	0.708
YWHAQ	YWHAE	0.999	0.944	structurally_consistent (dimer)
SAMD4A	YWHAE	0.998	0.487119479865
FAM53B	YWHAB	0.998
YWHAG	SFN	0.998	0.644	structurally_consistent (dimer)
HDAC4	YWHAB	0.997	0.394
SAMD4A	YWHAB	0.997	0.301325581395
SAMD4B	YWHAG	0.997	0.3265
YWHAQ	SFN	0.997	0.51	structurally_consistent (dimer)
HDAC4	YWHAG	0.996	0.508
SAMD4B	YWHAE	0.996	0.224
SAMD4B	YWHAB	0.996	0.202722222222
YWHAG	IRS2	0.995	0.532
YWHAQ	FAM53B	0.995
HDAC4	YWHAQ	0.995	0.394	structurally_consistent (dimer)
FAM53B	YWHAE	0.994
SFN	YWHAB	0.994	0.716	structurally_consistent (dimer)
YWHAG	ERRFI1	0.993	0.672	mutually_exclusive (P27348)
YWHAG	FOXO3	0.991	0.444
BRAF	YWHAB	0.991	0.396
YWHAG	BRAF	0.991	0.482
PLEKHA7	YWHAG	0.991	0.5056
YWHAG	PFKFB2	0.991	0.31	mutually_exclusive (P27348)
PFKFB2	YWHAQ	0.991	0.374	structurally_consistent (dimer)
YWHAQ	BRAF	0.99	0.424	structurally_consistent (dimer)
CRTC1	YWHAG	0.99	0.37136
YWHAG	CDC25B	0.99	0.346
PFKFB2	YWHAB	0.99	0.314	mutually_exclusive (P27348)
SFN	BAD	0.989	0.136	structurally_consistent (dimer)
HDAC4	PTOV1	0.989	0.13
SFN	FAM53B	0.989
YWHAQ	DMTN	0.987	0.572	structurally_consistent (dimer)
SPATA13	YWHAB	0.987	0.237693851718
IRS2	BRAF	0.987	0.11
YWHAG	TIAM1	0.986	0.534
YWHAQ	SAMD4A	0.986	0.533789595376
LNP1	YWHAE	0.986
YWHAG	DMTN	0.985	0.701020594966
PACS2	YWHAG	0.985	0.594
YWHAG	BAD	0.985	0.508
SFN	YWHAE	0.984	0.643333333333	structurally_consistent (dimer)
IRS2	YWHAE	0.984	0.460909090909
DMTN	YWHAE	0.984	0.189733333333
YWHAG	DENND4A	0.984	0.488	mutually_exclusive (P27348)
SRGAP2	YWHAG	0.984	0.454
PI4KB	YWHAG	0.983	0.24
YWHAG	SPIRE1	0.983	0.3
IRS2	YWHAB	0.983	0.38679787234
CDC25B	YWHAB	0.983	0.38
IRS2	PTOV1	0.983	0.098
PTOV1	YWHAB	0.982	0.30004
PACS2	YWHAQ	0.982	0.6354
YWHAG	LNP1	0.982
HDAC4	IRS2	0.981	0.140666666667
YWHAQ	LNP1	0.981
YWHAG	FOXO1	0.981	0.445171521036	mutually_exclusive (P27348)
YWHAQ	BAD	0.981	0.404	structurally_consistent (dimer)
PARD3	HDAC4	0.98	0.106
PARD3	YWHAG	0.98	0.307514285714
SRGAP1	SRGAP2	0.98	0.202
LNP1	YWHAB	0.98
YWHAG	PTPN3	0.979	0.4224
BAD	YWHAB	0.979	0.12361779661
YWHAG	PTOV1	0.979	0.365892
SPIRE2	YWHAB	0.979
YWHAQ	CDC25B	0.978	0.39	structurally_consistent (dimer)
SAMD4B	SAMD4A	0.978	0.068
YWHAQ	SPIRE1	0.977	0.276
YWHAQ	SPATA13	0.976	0.304
YWHAG	KIAA0930	0.976	0.325649224535
HDAC5	YWHAB	0.976	0.4	mutually_exclusive (P31947)
SRGAP1	YWHAG	0.976	0.49
YWHAQ	IRS2	0.976	0.488
PTPN3	YWHAB	0.975	0.36
BRAF	YWHAE	0.975	0.432
YWHAQ	PTPN3	0.975	0.580166666667
YWHAG	SPATA13	0.975	0.382862588235
SRGAP2	YWHAB	0.974	0.1955
SFN	KIAA0930	0.974	0.222	structurally_consistent (dimer)
DMTN	YWHAB	0.974	0.369648247322
SPIRE1	YWHAB	0.973	0.204
YWHAG	ZNF395	0.973
FOXO1	YWHAB	0.972	0.465147618658	mutually_exclusive (P27348)
YWHAG	SASH1	0.971	0.498
YWHAQ	FOXO1	0.97	0.508	structurally_consistent (dimer)
HDAC4	YWHAE	0.969	0.564114834206
KIAA0930	YWHAB	0.969	0.24373134257
CRTC1	YWHAB	0.967	0.15486779661
DMTN	SFN	0.966	0.5104
YWHAG	SPIRE2	0.965
YWHAG	HDAC5	0.964	0.405777777778
SFN	LNP1	0.964
PARD3	PTOV1	0.964	0.088
YWHAQ	PTOV1	0.963	0.364
PARD3	YWHAB	0.962	0.242460522273
YWHAG	HIVEP1	0.961	0.372
YWHAG	SH3RF3	0.961	0.258
PACS2	YWHAB	0.96	0.376
TIAM1	YWHAB	0.958	0.300446428571
SFN	BRAF	0.957	0.266
PLEKHA7	YWHAB	0.957	0.263648247322
DENND4A	YWHAB	0.957	0.314	mutually_exclusive (P27348)
YWHAQ	TIAM1	0.956	0.386
SRGAP1	YWHAB	0.955	0.304504885649
YWHAQ	DENND4A	0.952	0.338	structurally_consistent (dimer)
YWHAQ	KIAA0930	0.952	0.292436781609	structurally_consistent (dimer)
YWHAG	ANKRD34A	0.952
TBC1D1	YWHAG	0.951	0.582855106888
SRGAP1	YWHAQ	0.95	0.498
PI4KB	YWHAB	0.948	0.224714589666
SPATA13	YWHAE	0.946	0.392366471735
ANKRD34A	YWHAB	0.944
CDC25B	YWHAE	0.944	0.503
BAD	YWHAE	0.932	0.198
CRTC1	YWHAQ	0.93	0.208	structurally_consistent (dimer)
YWHAQ	ZNF395	0.928
TBC1D1	YWHAB	0.925	0.372
PI4KB	YWHAQ	0.921	0.246
ZNF395	YWHAE	0.917
ERRFI1	YWHAE	0.915	0.503	mutually_exclusive (P27348)
YWHAQ	FOXO3	0.911	0.446
SFN	ZNF395	0.907
YWHAQ	HDAC5	0.903	0.4575
YWHAQ	SASH1	0.903	0.326	structurally_consistent (dimer)
SASH1	YWHAB	0.901	0.328
SRGAP2	YWHAQ	0.9	0.478	structurally_consistent (dimer)
FOXO3	YWHAB	0.899	0.382
SPIRE2	BRAF	0.898
ZNF395	YWHAB	0.89
SH3RF3	YWHAB	0.865	0.252
KIAA0930	YWHAE	0.865	0.344027324121
ERRFI1	YWHAB	0.864	0.478317290553	mutually_exclusive (P27348)
YWHAQ	SPIRE2	0.854
SAMD4B	YWHAQ	0.853	0.346
SFN	SPATA13	0.843	0.214875
SPIRE2	IRS2	0.838
SFN	SAMD4A	0.835	0.356
SPIRE2	SPIRE1	0.781
PTOV1	YWHAE	0.767	0.354133333333
PLEKHA7	YWHAQ	0.723	0.417142857143
YWHAQ	ERRFI1	0.722	0.712	structurally_consistent (dimer)
SFN	ERRFI1	0.702	0.706672839506	mutually_exclusive (P27348) structurally_consistent (dimer)
PARD3	IRS2	0.667	0.078
TBC1D1	YWHAQ	0.652	0.454
PARD3	YWHAQ	0.615	0.227514285714
PACS2	YWHAE	0.611	0.501679479865
PLEKHA7	PFKFB2	0.605	0.044
PFKFB2	SPIRE1	0.605	0.042
CDC25B	FOXO3	0.605	0.138
CDC25B	FAM53B	0.605
PLEKHA7	SPIRE1	0.605	0.092
HIVEP1	YWHAB	0.602	0.276
SFN	CDC25B	0.577	0.242
DENND4A	IRS2	0.566	0.08
IRS2	FOXO1	0.564	0.09
FOXO3	BAD	0.561	0.132
FAM53B	BAD	0.561
PI4KB	FOXO3	0.556	0.07
SAMD4B	FOXO1	0.549	0.108
SAMD4B	IRS2	0.548	0.1
CRTC1	FOXO3	0.543	0.208
HDAC4	CRTC1	0.54	0.188
HDAC4	TIAM1	0.54	0.218
CDC25B	SPIRE1	0.54	0.132
HDAC4	HDAC5	0.54	0.158
HDAC4	FOXO3	0.54	0.168
HDAC4	FAM53B	0.54
FOXO3	KIAA0930	0.539	0.08
SRGAP2	PFKFB2	0.539	0.038	mutually_exclusive (P27348)
PI4KB	CDC25B	0.539	0.118
SASH1	SAMD4A	0.539	0.086
PLEKHA7	PI4KB	0.539	0.044
SASH1	SPIRE1	0.539	0.142
CRTC1	SASH1	0.539	0.1	mutually_exclusive (P27348)
TBC1D1	CDC25B	0.539	0.25
PI4KB	IRS2	0.539	0.076
SPIRE2	SASH1	0.539
SASH1	IRS2	0.539	0.1
SRGAP2	CDC25B	0.539	0.0884395604396	mutually_exclusive (P27348)
PLEKHA7	KIAA0930	0.539	0.058
PFKFB2	BAD	0.539	0.068	mutually_exclusive (P27348)
SPIRE1	BAD	0.539	0.124
PLEKHA7	CDC25B	0.539	0.126
PFKFB2	CDC25B	0.539	0.054	mutually_exclusive (P27348)
PLEKHA7	DENND4A	0.539	0.084
SAMD4B	SASH1	0.539	0.058
SASH1	FAM53B	0.539
SASH1	HDAC5	0.539	0.132
CDC25B	BAD	0.539	0.126	mutually_exclusive (P27348)
SRGAP2	BAD	0.539	0.1	mutually_exclusive (P27348)
PLEKHA7	BAD	0.539	0.088
PLEKHA7	SASH1	0.539	0.11
SASH1	BAD	0.539	0.048	mutually_exclusive (P27348)
TBC1D1	IRS2	0.539	0.116
SRGAP2	SPIRE1	0.539	0.084
CDC25B	SASH1	0.539	0.07	mutually_exclusive (P27348)
TBC1D1	PFKFB2	0.539	0.06
PFKFB2	KIAA0930	0.539	0.092	mutually_exclusive (P27348)
KIAA0930	SPIRE1	0.539	0.05
KIAA0930	FAM53B	0.539
KIAA0930	BAD	0.539	0.064
HDAC4	SASH1	0.539	0.09
TBC1D1	PLEKHA7	0.539	0.098
SASH1	TIAM1	0.539	0.22
PI4KB	FAM53B	0.539
PI4KB	BAD	0.539	0.064
PFKFB2	SASH1	0.539	0.066	mutually_exclusive (P27348)
PI4KB	SPIRE1	0.539	0.086
PI4KB	CRTC1	0.539	0.112
TBC1D1	HDAC4	0.539	0.118
PI4KB	PFKFB2	0.539	0.058
CDC25B	DENND4A	0.539	0.108
TBC1D1	TIAM1	0.539	0.158
PFKFB2	DENND4A	0.539	0.028	mutually_exclusive (P27348)
SASH1	FOXO1	0.539	0.202	mutually_exclusive (P27348)
CDC25B	KIAA0930	0.539	0.128	mutually_exclusive (P27348)
PI4KB	TIAM1	0.539	0.118
SASH1	FOXO3	0.539	0.126
CRTC1	IRS2	0.538	0.144
CRTC1	PFKFB2	0.534	0.04	mutually_exclusive (P27348)
TIAM1	HDAC5	0.534	0.102
PFKFB2	FOXO3	0.534	0.076
SRGAP2	HDAC4	0.534	0.128
TIAM1	FAM53B	0.534
PLEKHA7	FAM53B	0.534
CRTC1	TIAM1	0.534	0.156
TIAM1	BAD	0.534	0.126
HDAC4	DENND4A	0.534	0.082
SRGAP2	TIAM1	0.534	0.246
TIAM1	SPIRE1	0.534	0.202
IRS2	BAD	0.534	0.098
IRS2	SPIRE1	0.534	0.08
IRS2	FAM53B	0.534
CRTC1	KIAA0930	0.534	0.066	mutually_exclusive (P27348)
PFKFB2	IRS2	0.534	0.076
IRS2	KIAA0930	0.534	0.134
PFKFB2	FAM53B	0.534
HDAC4	PLEKHA7	0.534	0.13
SPIRE1	FAM53B	0.534
HDAC4	PFKFB2	0.534	0.046	mutually_exclusive (P27348)
CRTC1	SPIRE1	0.534	0.108
HDAC4	SPIRE1	0.534	0.204
CRTC1	BAD	0.534	0.214	mutually_exclusive (P27348)
CDC25B	HDAC5	0.534	0.088
PLEKHA7	HDAC5	0.534	0.086
CDC25B	IRS2	0.534	0.118
TIAM1	KIAA0930	0.534	0.04
PLEKHA7	CRTC1	0.534	0.088
HDAC4	KIAA0930	0.534	0.078
HDAC4	BAD	0.534	0.08
CRTC1	CDC25B	0.534	0.122	mutually_exclusive (P27348)
PLEKHA7	FOXO3	0.534	0.106
HDAC4	CDC25B	0.534	0.104
HDAC4	PI4KB	0.534	0.108
FOXO3	TIAM1	0.534	0.218
CDC25B	TIAM1	0.534	0.162
PFKFB2	TIAM1	0.534	0.124
TIAM1	DENND4A	0.534	0.155
TIAM1	IRS2	0.534	0.168
SRGAP2	FOXO1	0.528	0.218133333333	mutually_exclusive (P27348)
TBC1D1	FAM53B	0.516
TBC1D1	CRTC1	0.516	0.07
TBC1D1	HDAC5	0.516	0.11
SRGAP2	FAM53B	0.516
TBC1D1	DENND4A	0.516	0.126
DENND4A	FAM53B	0.516
SRGAP2	IRS2	0.513	0.216
CRTC1	FAM53B	0.511
IRS2	PTPN3	0.504	0.126
HDAC4	FOXO1	0.496	0.168
TIAM1	FOXO1	0.496	0.16
TBC1D1	BAD	0.494	0.046
PFKFB2	BRAF	0.494	0.084	mutually_exclusive (P27348)
BRAF	SPIRE1	0.494	0.076
PLEKHA7	BRAF	0.494	0.14
BRAF	BAD	0.494	0.134	mutually_exclusive (P27348)
TBC1D1	SPIRE1	0.494	0.06
CDC25B	BRAF	0.494	0.106	mutually_exclusive (P27348)
TBC1D1	KIAA0930	0.494	0.076
TIAM1	BRAF	0.494	0.126
FOXO3	IRS2	0.491	0.09
FOXO3	SPIRE1	0.489	0.178
BAD	FOXO1	0.489	0.09	mutually_exclusive (P27348)
PFKFB2	HDAC5	0.489	0.062
PFKFB2	FOXO1	0.489	0.102	mutually_exclusive (P27348)
SPIRE1	HDAC5	0.489	0.17
SPIRE1	FOXO1	0.489	0.158
BAD	HDAC5	0.489	0.104	mutually_exclusive (P31947)
HDAC4	BRAF	0.489	0.0952
PLEKHA7	FOXO1	0.489	0.112
KIAA0930	FOXO1	0.489	0.102	mutually_exclusive (P27348)
PI4KB	FOXO1	0.489	0.106
CDC25B	FOXO1	0.489	0.162	mutually_exclusive (P27348)
PI4KB	HDAC5	0.482	0.126
ANKRD34A	DENND4A	0.481
CDC25B	ANKRD34A	0.481
PLEKHA7	SH3RF3	0.481	0.064
ANKRD34A	KIAA0930	0.481
PI4KB	ANKRD34A	0.481
ANKRD34A	SPIRE1	0.481
CDC25B	SH3RF3	0.481	0.056
ANKRD34A	BAD	0.481
PLEKHA7	ANKRD34A	0.481
TBC1D1	ANKRD34A	0.481
SRGAP2	ANKRD34A	0.481
PFKFB2	ANKRD34A	0.481
SPIRE2	ANKRD34A	0.481
SAMD4B	KIAA0930	0.48	0.052
SAMD4B	PFKFB2	0.48	0.04
TBC1D1	SASH1	0.48	0.06
SAMD4B	SPIRE1	0.48	0.07
SAMD4B	FAM53B	0.48
SAMD4B	BAD	0.48	0.078
CRTC1	SAMD4B	0.48	0.03
HDAC4	SAMD4B	0.48	0.082
PI4KB	DENND4A	0.48	0.134
PI4KB	SPIRE2	0.48
PI4KB	SAMD4B	0.48	0.156
CDC25B	SAMD4A	0.48	0.08
SPIRE2	SAMD4A	0.48
FOXO3	SAMD4A	0.48	0.128
PI4KB	SASH1	0.48	0.064
SAMD4A	BRAF	0.48	0.08
SAMD4A	KIAA0930	0.48	0.048
PFKFB2	SAMD4A	0.48	0.07
SAMD4A	SPIRE1	0.48	0.148
SAMD4A	FAM53B	0.48
SAMD4A	HDAC5	0.48	0.138
HDAC4	SAMD4A	0.48	0.124
SASH1	BRAF	0.48	0.062	mutually_exclusive (P27348)
SAMD4A	BAD	0.48	0.112
PI4KB	SAMD4A	0.48	0.098
TBC1D1	SAMD4B	0.48	0.052
CRTC1	SAMD4A	0.48	0.082
PLEKHA7	SAMD4A	0.48	0.082
SPIRE2	KIAA0930	0.48
SRGAP2	SASH1	0.48	0.104	mutually_exclusive (P27348)
SASH1	KIAA0930	0.48	0.066	mutually_exclusive (P27348)
PLEKHA7	SPIRE2	0.48
TBC1D1	SAMD4A	0.48	0.066
SAMD4B	CDC25B	0.48	0.106
SRGAP2	KIAA0930	0.48	0.074	mutually_exclusive (P27348)
SPIRE2	CDC25B	0.48
PI4KB	KIAA0930	0.48	0.15
SRGAP2	PI4KB	0.48	0.15
SAMD4A	FOXO1	0.48	0.154
SAMD4B	TIAM1	0.48	0.132
SAMD4B	SPIRE2	0.48
HDAC4	SPIRE2	0.48
SPIRE2	TIAM1	0.48
SASH1	DENND4A	0.48	0.076
PFKFB2	SPIRE2	0.48
SPIRE2	BAD	0.48
DENND4A	KIAA0930	0.48	0.142
DENND4A	SPIRE1	0.48	0.132
TIAM1	SAMD4A	0.48	0.12
DENND4A	BAD	0.48	0.058
KIAA0930	HDAC5	0.477	0.132	mutually_exclusive (P31947)
SAMD4A	IRS2	0.476	0.196
FAM53B	FOXO1	0.472
TBC1D1	FOXO3	0.471	0.114
FOXO3	BRAF	0.471	0.126
BRAF	HDAC5	0.471	0.206
TBC1D1	FOXO1	0.471	0.158
PARD3	KIAA0930	0.471	0.046
PARD3	PFKFB2	0.471	0.028
PARD3	SPIRE1	0.471	0.036
CRTC1	BRAF	0.471	0.072	mutually_exclusive (P27348)
PARD3	BAD	0.471	0.05
BRAF	FAM53B	0.471
PARD3	CDC25B	0.471	0.094
SRGAP1	YWHAE	0.47	0.335433138402
ANKRD34A	FOXO3	0.47
SH3RF3	ANKRD34A	0.47
SAMD4B	ANKRD34A	0.47
ANKRD34A	SAMD4A	0.47
ANKRD34A	HDAC5	0.47
SAMD4B	SH3RF3	0.47	0.076
ANKRD34A	SASH1	0.47
SH3RF3	SASH1	0.47	0.064
HDAC4	ANKRD34A	0.47
HDAC4	SH3RF3	0.47	0.094
ANKRD34A	FAM53B	0.47
CRTC1	ANKRD34A	0.47
SH3RF3	TIAM1	0.47	0.076
SH3RF3	SAMD4A	0.47	0.118
SH3RF3	IRS2	0.47	0.122
ANKRD34A	IRS2	0.47
ANKRD34A	TIAM1	0.47
SRGAP2	FOXO3	0.469	0.208
CRTC1	DENND4A	0.467	0.056	mutually_exclusive (P27348)
PARD3	TIAM1	0.466	0.134
FOXO3	FAM53B	0.466
FAM53B	HDAC5	0.466
BRAF	FOXO1	0.466	0.158	mutually_exclusive (P27348)
DENND4A	BRAF	0.466	0.13	mutually_exclusive (P27348)
SRGAP2	BRAF	0.466	0.144	mutually_exclusive (P27348)
FOXO3	HDAC5	0.463	0.348
DENND4A	SAMD4A	0.461	0.144
HDAC5	FOXO1	0.46	0.15
CRTC1	FOXO1	0.459	0.092	mutually_exclusive (P27348)
TBC1D1	SH3RF3	0.458	0.086
SH3RF3	DENND4A	0.458	0.046
SPIRE2	SH3RF3	0.458
SRGAP2	SH3RF3	0.458	0.08
PARD3	SASH1	0.457	0.064
SPIRE2	HDAC5	0.457
TBC1D1	SPIRE2	0.457
TBC1D1	SRGAP2	0.457	0.126842105263
SPIRE2	FOXO3	0.457
CRTC1	SPIRE2	0.457
PARD3	SAMD4A	0.457	0.088
SPIRE2	DENND4A	0.457
SPIRE2	FOXO1	0.457
SPIRE2	FAM53B	0.457
SRGAP2	SPIRE2	0.457
PLEKHA7	PTPN3	0.456	0.138
DENND4A	FOXO1	0.454	0.076	mutually_exclusive (P27348)
CRTC1	HDAC5	0.454	0.112
ZNF395	DENND4A	0.45
PTPN3	YWHAE	0.448	0.454925925926
SFN	SASH1	0.447	0.312
FOXO3	PTOV1	0.447	0.116
SFN	TIAM1	0.447	0.368548387097
SFN	FOXO3	0.447	0.452
SASH1	PTOV1	0.447	0.08
SFN	IRS2	0.447	0.336
PFKFB2	SFN	0.447	0.432461538462	mutually_exclusive (P27348)
CRTC1	SFN	0.447	0.171767901235	mutually_exclusive (P27348)
HDAC4	SFN	0.447	0.394461139896
CRTC1	PTOV1	0.447	0.094
CDC25B	PTOV1	0.447	0.088
PTOV1	BRAF	0.447	0.062
SFN	PTPN3	0.447	0.32
SRGAP1	SFN	0.447	0.244685714286
PLEKHA7	PTOV1	0.447	0.142
PFKFB2	PTOV1	0.447	0.106
PACS2	PTOV1	0.447	0.104
SRGAP2	PTOV1	0.447	0.176
PTOV1	SPIRE1	0.447	0.138
PTOV1	FAM53B	0.447
PTOV1	BAD	0.447	0.094	mutually_exclusive (P31947)
PTOV1	HDAC5	0.447	0.14	mutually_exclusive (P31947)
PTOV1	PTPN3	0.447	0.108
PTOV1	KIAA0930	0.447	0.094	mutually_exclusive (P31947)
PACS2	SFN	0.447	0.314
SFN	HDAC5	0.447	0.274417508418	structurally_consistent (dimer)
TIAM1	PTOV1	0.447	0.114
SFN	FOXO1	0.447	0.546	mutually_exclusive (P27348)
SH3RF3	HDAC5	0.447	0.116
CRTC1	SH3RF3	0.447	0.094
SH3RF3	FOXO3	0.447	0.098
SH3RF3	FAM53B	0.447
SH3RF3	BAD	0.437	0.14
SH3RF3	SPIRE1	0.437	0.1
SH3RF3	KIAA0930	0.437	0.128
ANKRD34A	BRAF	0.437
PI4KB	SH3RF3	0.437	0.188
PFKFB2	SH3RF3	0.437	0.15
PI4KB	BRAF	0.436	0.104
TBC1D1	PI4KB	0.436	0.048
BRAF	KIAA0930	0.436	0.11	mutually_exclusive (P27348)
CDC25B	HIVEP1	0.432	0.152
PARD3	ZNF395	0.428
SRGAP2	ZNF395	0.428
ZNF395	BRAF	0.428
PI4KB	ZNF395	0.428
ANKRD34A	FOXO1	0.426
SH3RF3	BRAF	0.414	0.082
PARD3	ANKRD34A	0.414
TBC1D1	BRAF	0.413	0.136
SH3RF3	FOXO1	0.404	0.116
PARD3	HDAC5	0.399	0.098
SRGAP2	SAMD4B	0.396	0.034
HIVEP1	HDAC5	0.395	0.088
SASH1	YWHAE	0.393	0.344
HIVEP1	SAMD4A	0.391	0.132424242424
SPIRE2	HIVEP1	0.391
PLEKHA7	IRS2	0.39	0.158
PACS2	PLEKHA7	0.385	0.1
SRGAP1	CDC25B	0.385	0.156
PACS2	PFKFB2	0.385	0.064
SRGAP1	PARD3	0.385	0.06
SRGAP1	BAD	0.385	0.08
PTPN3	BAD	0.385	0.128
PACS2	SPIRE1	0.385	0.092
CDC25B	PTPN3	0.385	0.092
PARD3	PTPN3	0.377	0.072
PFKFB2	YWHAE	0.37	0.49695890411	mutually_exclusive (P27348)
SPIRE1	YWHAE	0.37	0.368
SAMD4B	HDAC5	0.359	0.21
IRS2	HDAC5	0.353	0.102
SRGAP1	FOXO1	0.324	0.212
SRGAP1	HDAC4	0.324	0.204
PTPN3	FOXO1	0.324	0.162
HDAC4	PTPN3	0.324	0.134
SRGAP1	TIAM1	0.319	0.256
FOXO3	PTPN3	0.319	0.2
PACS2	FOXO1	0.319	0.198
PACS2	HDAC4	0.319	0.15
SRGAP1	PFKFB2	0.319	0.076
PACS2	CRTC1	0.319	0.13
PFKFB2	PTPN3	0.319	0.084
SRGAP1	PLEKHA7	0.319	0.154
PACS2	SRGAP1	0.319	0.212
PACS2	PTPN3	0.319	0.088
SRGAP1	SPIRE1	0.319	0.156
PACS2	FAM53B	0.319
SRGAP1	HDAC5	0.319	0.082
PTPN3	SPIRE1	0.319	0.13
PTPN3	FAM53B	0.319
SRGAP1	FOXO3	0.319	0.148
PACS2	FOXO3	0.319	0.146
PTPN3	HDAC5	0.319	0.154
CRTC1	PTPN3	0.319	0.18
SRGAP1	CRTC1	0.319	0.144
SRGAP1	IRS2	0.319	0.272
TIAM1	PTPN3	0.319	0.144
SRGAP1	FAM53B	0.319
SRGAP1	PTPN3	0.319	0.186
PACS2	TIAM1	0.319	0.16
PACS2	HDAC5	0.319	0.096
FOXO3	FOXO1	0.317	0.168
SAMD4B	HIVEP1	0.314	0.07
PARD3	FOXO1	0.309	0.1
SRGAP2	PLEKHA7	0.301	0.112
SRGAP2	HDAC5	0.298	0.208
PARD3	FAM53B	0.294
SRGAP1	KIAA0930	0.29	0.088
PTPN3	KIAA0930	0.29	0.148
PACS2	BAD	0.29	0.144
SRGAP1	DENND4A	0.29	0.086
DENND4A	PTPN3	0.29	0.102
PACS2	CDC25B	0.29	0.082
SRGAP2	DENND4A	0.283	0.034
PACS2	BRAF	0.283	0.142
SRGAP1	PI4KB	0.283	0.178
PI4KB	PTPN3	0.283	0.14
TBC1D1	SRGAP1	0.283	0.112
PACS2	SASH1	0.283	0.116
BRAF	PTPN3	0.283	0.104
SASH1	PTPN3	0.283	0.09
PACS2	PI4KB	0.283	0.134
PACS2	KIAA0930	0.283	0.066
SRGAP1	BRAF	0.283	0.15
PACS2	TBC1D1	0.283	0.118
TBC1D1	PTPN3	0.283	0.142
PACS2	DENND4A	0.283	0.116
SRGAP1	SASH1	0.283	0.136
FOXO3	DENND4A	0.282	0.1
CRTC1	YWHAE	0.28	0.355333333333
SRGAP2	CRTC1	0.278	0.13	mutually_exclusive (P27348)
DENND4A	HDAC5	0.278	0.086
HIVEP1	KIAA0930	0.278	0.066
SRGAP2	YWHAE	0.278	0.42
PACS2	SAMD4B	0.262	0.068
SRGAP2	SAMD4A	0.254	0.14
SAMD4B	DENND4A	0.254	0.04
SAMD4B	FOXO3	0.254	0.132
HDAC5	YWHAE	0.249	0.52880733195	mutually_exclusive (P31947)
TBC1D1	SFN	0.249	0.332
TBC1D1	PTOV1	0.249	0.102
SRGAP1	ZNF395	0.247
PLEKHA7	ZNF395	0.247
ZNF395	SAMD4A	0.247
PACS2	ANKRD34A	0.247
SAMD4B	ZNF395	0.247
SH3RF3	HIVEP1	0.247	0.112
ZNF395	FOXO3	0.247
ZNF395	SPIRE1	0.247
ZNF395	BAD	0.247
PFKFB2	ZNF395	0.247
ZNF395	FAM53B	0.247
PACS2	SH3RF3	0.247	0.09
SASH1	HIVEP1	0.247	0.072
ZNF395	HDAC5	0.247
CRTC1	ZNF395	0.247
ANKRD34A	HIVEP1	0.247
ZNF395	IRS2	0.247
SPIRE2	ZNF395	0.247
ZNF395	KIAA0930	0.247
HDAC4	ZNF395	0.247
ZNF395	TIAM1	0.247
PACS2	ZNF395	0.247
ZNF395	PTPN3	0.247
TBC1D1	ZNF395	0.247
CDC25B	ZNF395	0.247
PTOV1	FOXO1	0.246	0.142
SAMD4B	BRAF	0.245	0.092
PLEKHA7	SFN	0.239	0.3584
SFN	SPIRE1	0.239	0.224564102564
SRGAP1	SH3RF3	0.239	0.06
ZNF395	FOXO1	0.239
ZNF395	SASH1	0.239
SH3RF3	PTPN3	0.239	0.072
ANKRD34A	PTPN3	0.239
SRGAP1	ANKRD34A	0.239
FOXO3	HIVEP1	0.238	0.22
CRTC1	HIVEP1	0.238	0.088
HIVEP1	FOXO1	0.238	0.09
HDAC4	HIVEP1	0.238	0.118
PFKFB2	HIVEP1	0.238	0.076
HIVEP1	FAM53B	0.238
HIVEP1	PTPN3	0.238	0.082
HIVEP1	BAD	0.238	0.094
SRGAP1	SAMD4A	0.238	0.246
SAMD4A	PTPN3	0.238	0.124
SRGAP1	SPIRE2	0.238
PACS2	SPIRE2	0.238
HIVEP1	SPIRE1	0.238	0.102
HIVEP1	IRS2	0.238	0.106
PLEKHA7	HIVEP1	0.238	0.09
SRGAP1	PTOV1	0.238	0.118
HIVEP1	TIAM1	0.238	0.212
PACS2	HIVEP1	0.238	0.072
SRGAP1	HIVEP1	0.238	0.154
HIVEP1	BRAF	0.238	0.104
PACS2	SAMD4A	0.238	0.076
SPIRE2	PTPN3	0.238
PI4KB	HIVEP1	0.238	0.116
PARD3	DENND4A	0.236	0.044
SAMD4B	PTPN3	0.232	0.114
PARD3	SPIRE2	0.231
PLEKHA7	TIAM1	0.23	0.14
PARD3	PI4KB	0.226	0.046
SRGAP2	PARD3	0.225	0.052
PACS2	IRS2	0.213	0.098
ERRFI1	ZNF395	0.21
DMTN	ERRFI1	0.21	0.098	mutually_exclusive (P27348)
PARD3	SH3RF3	0.209	0.13
SAMD4B	SFN	0.208	0.09
TBC1D1	PARD3	0.201	0.056
TBC1D1	HIVEP1	0.198	0.07
PACS2	PARD3	0.191	0.044
SRGAP2	PTPN3	0.191	0.132
SRGAP2	SFN	0.189	0.266
SAMD4B	PTOV1	0.189	0.052
PARD3	SFN	0.189	0.234
SFN	DENND4A	0.189	0.203047619048	mutually_exclusive (P27348)
FOXO1	YWHAE	0.18	0.476746666667	mutually_exclusive (P27348)
DENND4A	PTOV1	0.177	0.034
PACS2	SRGAP2	0.168	0.156133333333
HIVEP1	DENND4A	0.158	0.106
PI4KB	PTOV1	0.155	0.128
PI4KB	SFN	0.155	0.116
PARD3	HIVEP1	0.153	0.062
SRGAP1	SAMD4B	0.153	0.136
PARD3	CRTC1	0.153	0.03
TIAM1	YWHAE	0.146	0.445033138402
SPIRE2	YWHAE	0.145
PLEKHA7	SAMD4B	0.144	0.072
PARD3	SAMD4B	0.126	0.04
DMTN	ANKRD34A	0.123
DMTN	SH3RF3	0.123	0.098
PARD3	FOXO3	0.12	0.086
TBC1D1	YWHAE	0.119	0.362
DENND4A	YWHAE	0.116	0.12	mutually_exclusive (P27348)
PARD3	PLEKHA7	0.113	0.062
YWHAQ	HIVEP1	0.111	0.414
YWHAQ	SH3RF3	0.106	0.32
SAMD4A	PTOV1	0.096	0.066
SPIRE2	PTOV1	0.096
HIVEP1	PTOV1	0.096	0.108
SFN	SPIRE2	0.096
SFN	ANKRD34A	0.094
SFN	SH3RF3	0.094	0.114
ANKRD34A	PTOV1	0.094
SH3RF3	PTOV1	0.094	0.12
YWHAQ	ANKRD34A	0.093
PARD3	BRAF	0.089	0.076
SRGAP2	HIVEP1	0.088	0.184
SFN	HIVEP1	0.087	0.372090909091
PI4KB	YWHAE	0.086	0.21
ERRFI1	PTOV1	0.082	0.082	mutually_exclusive (P31947)
DMTN	PTOV1	0.081	0.11
DMTN	HDAC5	0.079	0.076
DMTN	SPIRE1	0.079	0.108
SAMD4B	ERRFI1	0.079	0.054
ERRFI1	FOXO1	0.079	0.112	mutually_exclusive (P27348)
DMTN	HIVEP1	0.079	0.132
ERRFI1	HIVEP1	0.079	0.064
DMTN	FOXO3	0.079	0.118
ERRFI1	IRS2	0.079	0.164
PFKFB2	DMTN	0.079	0.064	mutually_exclusive (P27348)
ERRFI1	SASH1	0.079	0.072	mutually_exclusive (P27348)
DMTN	TIAM1	0.079	0.272
CRTC1	DMTN	0.079	0.09	mutually_exclusive (P27348)
ERRFI1	DENND4A	0.079	0.116	mutually_exclusive (P27348)
HDAC4	ERRFI1	0.079	0.116
ERRFI1	HDAC5	0.079	0.08	mutually_exclusive (P31947)
DMTN	SAMD4A	0.079	0.074
DMTN	BAD	0.079	0.08	mutually_exclusive (P27348)
DMTN	ZNF395	0.079
ERRFI1	TIAM1	0.079	0.186
SH3RF3	ZNF395	0.079
DMTN	CDC25B	0.079	0.138	mutually_exclusive (P27348)
PARD3	DMTN	0.079	0.106
TBC1D1	DMTN	0.079	0.094
ERRFI1	ANKRD34A	0.079
PFKFB2	ERRFI1	0.079	0.052	mutually_exclusive (P27348)
ERRFI1	SPIRE1	0.079	0.104
ERRFI1	SH3RF3	0.079	0.104
PLEKHA7	ERRFI1	0.079	0.086
ERRFI1	FAM53B	0.079
PARD3	ERRFI1	0.079	0.062
DMTN	FOXO1	0.079	0.134	mutually_exclusive (P27348)
ERRFI1	BRAF	0.079	0.038	mutually_exclusive (P27348)
DMTN	PTPN3	0.079	0.182
PACS2	ERRFI1	0.079	0.046
DMTN	FAM53B	0.079
ERRFI1	BAD	0.079	0.088
SRGAP2	DMTN	0.079	0.13	mutually_exclusive (P27348)
HDAC4	DMTN	0.079	0.108
TBC1D1	ERRFI1	0.079	0.094
ERRFI1	PTPN3	0.079	0.102
ZNF395	HIVEP1	0.079
ZNF395	ANKRD34A	0.079
PACS2	DMTN	0.079	0.092
ERRFI1	FOXO3	0.079	0.08
ERRFI1	KIAA0930	0.079	0.062
SRGAP1	DMTN	0.079	0.166
ERRFI1	SAMD4A	0.079	0.088
SRGAP2	ERRFI1	0.079	0.126	mutually_exclusive (P27348)
PI4KB	DMTN	0.079	0.104
ERRFI1	SPIRE2	0.079
SAMD4B	DMTN	0.079	0.058
PI4KB	ERRFI1	0.079	0.132
PLEKHA7	DMTN	0.079	0.15
SRGAP1	ERRFI1	0.079	0.172
DMTN	KIAA0930	0.079	0.064	mutually_exclusive (P27348)
CRTC1	ERRFI1	0.079	0.058	mutually_exclusive (P27348)
DMTN	IRS2	0.079	0.134
DMTN	SASH1	0.079	0.152	mutually_exclusive (P27348)
DMTN	SPIRE2	0.079
DMTN	DENND4A	0.079	0.038
DMTN	BRAF	0.079	0.096	mutually_exclusive (P27348)
ZNF395	PTOV1	0.079
ERRFI1	CDC25B	0.079	0.08	mutually_exclusive (P27348)
PLEKHA7	YWHAE	0.075	0.188
FOXO3	YWHAE	0.059	0.426900900901
HIVEP1	YWHAE	0.059	0.4271875
ANKRD34A	YWHAE	0.059
SFN	PTOV1	0.057	0.256	structurally_consistent (dimer)
SH3RF3	YWHAE	0.038	0.324
PARD3	YWHAE	0.02	0.268647058824

Related Complexes

Genename	Complexes
PLEKHA7	huMAP3_01010.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
HIVEP1	huMAP3_04087.1 huMAP3_07838.1 huMAP3_08154.1 huMAP3_09810.1 huMAP3_11570.1 huMAP3_12772.1 huMAP3_15164.1
TIAM1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
PI4KB	huMAP3_01010.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_12954.1
YWHAQ	huMAP3_01787.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
DENND4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14817.1
PACS2	huMAP3_00173.1 huMAP3_04537.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10190.1 huMAP3_10808.1 huMAP3_12897.1
SAMD4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14098.1
SRGAP1	huMAP3_00235.1 huMAP3_04537.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10496.1 huMAP3_10808.1 huMAP3_11883.1 huMAP3_12561.1 huMAP3_12897.1 huMAP3_13128.1 huMAP3_13156.1 huMAP3_13524.1
CDC25B	huMAP3_03088.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07002.1 huMAP3_07596.1 huMAP3_07691.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12897.1
IRS2	huMAP3_04537.1 huMAP3_07081.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_08092.1 huMAP3_09358.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_11629.1 huMAP3_12185.1 huMAP3_12897.1 huMAP3_14118.1
SPATA13	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SPIRE2	huMAP3_02462.1 huMAP3_04537.1 huMAP3_06108.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13929.1 huMAP3_15248.1
HECTD4	huMAP3_00381.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_11206.1 huMAP3_11737.1 huMAP3_12440.1
SASH1	huMAP3_03955.1 huMAP3_04051.1 huMAP3_04537.1 huMAP3_07306.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SAMD4B	huMAP3_01010.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14098.1
FOXO3	huMAP3_03955.1 huMAP3_04051.1 huMAP3_04537.1 huMAP3_06135.1 huMAP3_07306.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
DMTN	huMAP3_01787.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_12991.1
TBC1D1	huMAP3_00216.1 huMAP3_07838.1 huMAP3_08921.1 huMAP3_09810.1 huMAP3_10179.1 huMAP3_11382.1 huMAP3_12897.1
LNP1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13672.1
PTOV1	huMAP3_04537.1 huMAP3_05308.1 huMAP3_07324.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_08154.1 huMAP3_09641.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1
ANKRD34A	huMAP3_03955.1 huMAP3_06135.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_12897.1
BRAF	huMAP3_04537.1 huMAP3_04917.1 huMAP3_07588.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11448.1 huMAP3_12897.1
PTPN3	huMAP3_04537.1 huMAP3_06025.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11201.1 huMAP3_12897.1
KIAA0930	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11622.1 huMAP3_12897.1
YWHAB	huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
PFKFB2	huMAP3_01672.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
ZNF395	huMAP3_03955.1 huMAP3_06135.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_12897.1
SFN	huMAP3_01787.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SPIRE1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13929.1 huMAP3_15248.1
FAM53B	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
BAD	huMAP3_04537.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11267.1 huMAP3_12897.1 huMAP3_13356.1
YWHAE	huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13503.1
SH3RF3	huMAP3_03955.1 huMAP3_06135.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_12897.1
HDAC5	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
CRTC1	huMAP3_01010.1 huMAP3_04051.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13650.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
ERRFI1	huMAP3_02129.1 huMAP3_04051.1 huMAP3_07305.1 huMAP3_07767.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10717.1 huMAP3_12897.1 huMAP3_13626.1 huMAP3_14478.1
FOXO1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
HDAC4	huMAP3_00531.1 huMAP3_04537.1 huMAP3_06269.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_12897.1 huMAP3_14118.1
YWHAG	huMAP3_01010.1 huMAP3_03955.1 huMAP3_06135.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SRGAP2	huMAP3_00235.1 huMAP3_02549.1 huMAP3_04537.1 huMAP3_05977.1 huMAP3_07838.1 huMAP3_08222.1 huMAP3_09542.1 huMAP3_09810.1 huMAP3_10496.1 huMAP3_10808.1 huMAP3_11531.1 huMAP3_12897.1
A0A1X9RU27	huMAP3_01787.1 huMAP3_03955.1 huMAP3_07424.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07838.1

Complex Portal: CPX-24180