hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07840.1
Complex Portal: CPX-20702
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT-CO1 | Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
| UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | 5 | UniProt NCBI |
| COX7A2L | Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1) | 4 | UniProt NCBI |
| MT-CO3 | Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III) | 5 | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04260 | 1.2231585543e-10 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Cardiac muscle contraction |
| WP:WP111 | 7.68211010026e-10 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.81213806923e-09 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Oxidative phosphorylation |
| REAC:R-HSA-611105 | 2.09098163975e-09 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Respiratory electron transport |
| KEGG:04932 | 3.51498113927e-09 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Non-alcoholic fatty liver disease |
| WP:WP4396 | 4.22580749122e-09 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Nonalcoholic fatty liver disease |
| REAC:R-HSA-163200 | 5.81170850337e-09 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05415 | 1.37635786712e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Diabetic cardiomyopathy |
| KEGG:05208 | 2.33094248458e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 2.51109626226e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Thermogenesis |
| REAC:R-HSA-1428517 | 3.16392999894e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05012 | 5.3328196191e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Parkinson disease |
| KEGG:05020 | 6.17206457492e-08 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Prion disease |
| KEGG:05016 | 1.02604700914e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Huntington disease |
| KEGG:05014 | 2.52170502175e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Amyotrophic lateral sclerosis |
| GO:0005746 | 2.95357680296e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | mitochondrial respirasome |
| GO:0070469 | 2.95357680296e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | respirasome |
| KEGG:05010 | 3.21366321828e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Alzheimer disease |
| KEGG:05022 | 8.64787006633e-07 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Pathways of neurodegeneration - multiple diseases |
| GO:0006119 | 1.57543918424e-06 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | oxidative phosphorylation |
| GO:0070069 | 3.12047922974e-06 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | cytochrome complex |
| GO:0009060 | 5.14943131359e-06 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | aerobic respiration |
| GO:0045333 | 9.74490439673e-06 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | cellular respiration |
| GO:0015980 | 3.95539627218e-05 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | energy derivation by oxidation of organic compounds |
| GO:0015453 | 5.56532631373e-05 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | oxidoreduction-driven active transmembrane transporter activity |
| REAC:R-HSA-9707564 | 0.000100871107769 | 0.6 | MT-CO1 COX7A2L MT-CO3 | Cytoprotection by HMOX1 |
| GO:0019646 | 0.000168126820122 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | aerobic electron transport chain |
| GO:0098803 | 0.000196862025642 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | respiratory chain complex |
| GO:0045275 | 0.000211268761872 | 0.6 | MT-CO1 UQCRC1 UQCRQ | respiratory chain complex III |
| GO:0005750 | 0.000211268761872 | 0.6 | MT-CO1 UQCRC1 UQCRQ | mitochondrial respiratory chain complex III |
| GO:0042773 | 0.000229129100643 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | ATP synthesis coupled electron transport |
| GO:0042775 | 0.000229129100643 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | mitochondrial ATP synthesis coupled electron transport |
| REAC:R-HSA-5628897 | 0.000244866764891 | 0.6 | MT-CO1 COX7A2L MT-CO3 | TP53 Regulates Metabolic Genes |
| KEGG:01100 | 0.000265328202954 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Metabolic pathways |
| GO:0004129 | 0.000274621184043 | 0.6 | MT-CO1 COX7A2L MT-CO3 | cytochrome-c oxidase activity |
| GO:0016675 | 0.000274621184043 | 0.6 | MT-CO1 COX7A2L MT-CO3 | oxidoreductase activity, acting on a heme group of donors |
| HP:0003200 | 0.000289531742257 | 0.6 | MT-CO1 MT-CO3 UQCRQ | Ragged-red muscle fibers |
| GO:0006091 | 0.000311878876809 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | generation of precursor metabolites and energy |
| GO:0022904 | 0.000349949920328 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | respiratory electron transport chain |
| GO:0015078 | 0.000365836607157 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | proton transmembrane transporter activity |
| GO:0009055 | 0.000453524093368 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | electron transfer activity |
| GO:0022900 | 0.000492677093958 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | electron transport chain |
| WP:WP4921 | 0.000616503269292 | 0.4 | UQCRQ UQCRC1 | Mitochondrial complex III assembly |
| GO:0005743 | 0.000685713462832 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | mitochondrial inner membrane |
| CORUM:6442 | 0.000899678549321 | 0.4 | MT-CO1 MT-CO3 | Cytochrome c oxidase, mitochondrial |
| GO:0019866 | 0.000912561472256 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | organelle inner membrane |
| HP:0012544 | 0.001345957274 | 0.4 | MT-CO1 MT-CO3 | Elevated circulating aldolase concentration |
| HP:0003652 | 0.001345957274 | 0.4 | MT-CO1 MT-CO3 | Recurrent myoglobinuria |
| GO:0015399 | 0.00139398670092 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | primary active transmembrane transporter activity |
| HP:0030234 | 0.00179436403841 | 0.4 | MT-CO1 MT-CO3 | Highly elevated creatine kinase |
| GO:0098800 | 0.00243730532859 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | inner mitochondrial membrane protein complex |
| GO:0022853 | 0.00271599875109 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | active monoatomic ion transmembrane transporter activity |
| HP:0007327 | 0.00288300984678 | 0.4 | MT-CO1 MT-CO3 | Mixed demyelinating and axonal polyneuropathy |
| WP:WP4922 | 0.00290547066497 | 0.4 | MT-CO1 MT-CO3 | Mitochondrial complex IV assembly |
| REAC:R-HSA-9711123 | 0.00307789040511 | 0.6 | MT-CO1 COX7A2L MT-CO3 | Cellular response to chemical stress |
| HP:0005157 | 0.0035231963033 | 0.4 | MT-CO1 MT-CO3 | Concentric hypertrophic cardiomyopathy |
| HP:0003558 | 0.0035231963033 | 0.4 | MT-CO1 MT-CO3 | Viral infection-induced rhabdomyolysis |
| HP:0008305 | 0.0035231963033 | 0.4 | MT-CO1 MT-CO3 | Exercise-induced myoglobinuria |
| GO:0031966 | 0.00370824700397 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | mitochondrial membrane |
| HP:0012766 | 0.00422725674544 | 0.4 | MT-CO1 MT-CO3 | Widened cerebral subarachnoid space |
| HP:0000576 | 0.00422725674544 | 0.4 | MT-CO1 MT-CO3 | Centrocecal scotoma |
| HP:0040319 | 0.00422725674544 | 0.4 | MT-CO1 MT-CO3 | Dark urine |
| HP:0002905 | 0.00422725674544 | 0.4 | MT-CO1 MT-CO3 | Hyperphosphatemia |
| HP:0010969 | 0.00422725674544 | 0.4 | MT-CO1 MT-CO3 | Abnormality of glycolipid metabolism |
| REAC:R-HSA-1430728 | 0.00423241276191 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | Metabolism |
| HP:0007159 | 0.00499516489297 | 0.4 | MT-CO1 MT-CO3 | Fluctuations in consciousness |
| HP:0007067 | 0.00499516489297 | 0.4 | MT-CO1 MT-CO3 | Distal peripheral sensory neuropathy |
| GO:0005740 | 0.00514098194061 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | mitochondrial envelope |
| HP:0001427 | 0.00672241921037 | 0.4 | MT-CO1 MT-CO3 | Mitochondrial inheritance |
| HP:0100027 | 0.00672241921037 | 0.4 | MT-CO1 MT-CO3 | Recurrent pancreatitis |
| HP:0025268 | 0.00672241921037 | 0.4 | MT-CO1 MT-CO3 | Stuttering |
| HP:0100520 | 0.00768171284681 | 0.4 | MT-CO1 MT-CO3 | Oliguria |
| HP:0003554 | 0.00768171284681 | 0.4 | MT-CO1 MT-CO3 | Type 2 muscle fiber atrophy |
| HP:0012429 | 0.00768171284681 | 0.4 | MT-CO1 MT-CO3 | Aplasia/Hypoplasia of the cerebral white matter |
| HP:0200125 | 0.00870474912182 | 0.4 | MT-CO1 MT-CO3 | Mitochondrial respiratory chain defects |
| HP:0002401 | 0.0109419445801 | 0.4 | MT-CO1 MT-CO3 | Stroke-like episode |
| HP:0003287 | 0.0113572466436 | 0.6 | MT-CO1 MT-CO3 UQCRQ | Abnormality of mitochondrial metabolism |
| HP:0001345 | 0.0121560512731 | 0.4 | MT-CO1 MT-CO3 | Psychotic mentation |
| HP:0012086 | 0.0147751514018 | 0.4 | MT-CO1 MT-CO3 | Abnormal urinary color |
| HP:0002151 | 0.0159509868384 | 0.6 | MT-CO1 MT-CO3 UQCRQ | Increased serum lactate |
| HP:0002331 | 0.0161800923797 | 0.4 | MT-CO1 MT-CO3 | Recurrent paroxysmal headache |
| HP:0001716 | 0.0161800923797 | 0.4 | MT-CO1 MT-CO3 | Wolff-Parkinson-White syndrome |
| HP:0012103 | 0.0166933934022 | 0.6 | MT-CO1 MT-CO3 UQCRQ | Abnormality of the mitochondrion |
| HP:0012400 | 0.0176485923371 | 0.4 | MT-CO1 MT-CO3 | Abnormal circulating aldolase concentration |
| HP:0007763 | 0.0176485923371 | 0.4 | MT-CO1 MT-CO3 | Retinal telangiectasia |
| REAC:R-HSA-3700989 | 0.0192283148447 | 0.6 | MT-CO1 COX7A2L MT-CO3 | Transcriptional Regulation by TP53 |
| HP:0010794 | 0.0207761643339 | 0.4 | MT-CO1 MT-CO3 | Impaired visuospatial constructive cognition |
| HP:0001045 | 0.0224351839587 | 0.4 | MT-CO1 MT-CO3 | Vitiligo |
| HP:0005521 | 0.0224351839587 | 0.4 | MT-CO1 MT-CO3 | Disseminated intravascular coagulation |
| HP:0002913 | 0.0224351839587 | 0.4 | MT-CO1 MT-CO3 | Myoglobinuria |
| HP:0004309 | 0.0224351839587 | 0.4 | MT-CO1 MT-CO3 | Ventricular preexcitation |
| HP:0045037 | 0.0241576577336 | 0.4 | MT-CO1 MT-CO3 | Abnormality of jaw muscles |
| HP:0011037 | 0.0241576577336 | 0.4 | MT-CO1 MT-CO3 | Decreased urine output |
| HP:0000590 | 0.0259435594648 | 0.4 | MT-CO1 MT-CO3 | Progressive external ophthalmoplegia |
| HP:0004389 | 0.0259435594648 | 0.4 | MT-CO1 MT-CO3 | Intestinal pseudo-obstruction |
| HP:0002153 | 0.0259435594648 | 0.4 | MT-CO1 MT-CO3 | Hyperkalemia |
| HP:0012707 | 0.0259435594648 | 0.4 | MT-CO1 MT-CO3 | Elevated brain lactate level by MRS |
| HP:0004303 | 0.0264180981427 | 0.6 | MT-CO1 MT-CO3 UQCRQ | Abnormal muscle fiber morphology |
| WP:WP5380 | 0.0264781270697 | 0.4 | MT-CO1 MT-CO3 | 5q35 copy number variation |
| HP:0025045 | 0.0277928629638 | 0.4 | MT-CO1 MT-CO3 | Abnormal brain lactate level by MRS |
| HP:0001919 | 0.0277928629638 | 0.4 | MT-CO1 MT-CO3 | Acute kidney injury |
| HP:0007924 | 0.0297055420477 | 0.4 | MT-CO1 MT-CO3 | Slow decrease in visual acuity |
| HP:0003738 | 0.0297055420477 | 0.4 | MT-CO1 MT-CO3 | Exercise-induced myalgia |
| GO:0022804 | 0.029778729952 | 0.8 | MT-CO1 COX7A2L MT-CO3 UQCRC1 | active transmembrane transporter activity |
| HP:0100614 | 0.0316815705386 | 0.4 | MT-CO1 MT-CO3 | Myositis |
| GO:0098798 | 0.0348648607475 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | mitochondrial protein-containing complex |
| HP:0000829 | 0.0379894907585 | 0.4 | MT-CO1 MT-CO3 | Hypoparathyroidism |
| HP:0007302 | 0.0379894907585 | 0.4 | MT-CO1 MT-CO3 | Bipolar affective disorder |
| HP:0000622 | 0.0425110382594 | 0.4 | MT-CO1 MT-CO3 | Blurred vision |
| HP:0004305 | 0.0451245425813 | 0.8 | MT-CO1 UQCRC1 MT-CO3 UQCRQ | Involuntary movements |
| HP:0003201 | 0.0472853555832 | 0.4 | MT-CO1 MT-CO3 | Rhabdomyolysis |
| HP:0008316 | 0.0472853555832 | 0.4 | MT-CO1 MT-CO3 | Abnormal mitochondria in muscle tissue |
| HP:0000408 | 0.0472853555832 | 0.4 | MT-CO1 MT-CO3 | Progressive sensorineural hearing impairment |
| HP:0012704 | 0.0472853555832 | 0.4 | MT-CO1 MT-CO3 | Widened subarachnoid space |
| HP:0000751 | 0.0472853555832 | 0.4 | MT-CO1 MT-CO3 | Personality changes |
| GO:0031975 | 0.0494549382838 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | envelope |
| GO:0031967 | 0.0494549382838 | 1.0 | MT-CO1 UQCRC1 COX7A2L MT-CO3 UQCRQ | organelle envelope |
| HP:0000603 | 0.0497672375822 | 0.4 | MT-CO1 MT-CO3 | Central scotoma |
| HP:0030195 | 0.0497672375822 | 0.4 | MT-CO1 MT-CO3 | Fatigable weakness of swallowing muscles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UQCRB | UQCRC1 | 0.999 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| UQCRQ | UQCRC1 | 0.998 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| UQCRB | UQCRQ | 0.996 | 0.992 |
structurally_consistent (P22695)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| COX7A2L | UQCRQ | 0.995 | 0.726 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| COX7A2L | UQCRB | 0.989 | 0.882 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COX7A2L | UQCRC1 | 0.979 | 0.584 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| MT-CO1 | UQCRQ | 0.972 | 0.492 |
mutually_exclusive (P00403)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| MT-CO3 | MT-CO1 | 0.967 | 0.52 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| COX7A2L | MT-CO1 | 0.967 | 0.424 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| MT-CO1 | UQCRB | 0.961 | 0.898 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COX7A2L | MT-CO3 | 0.952 | 0.198 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| MT-CO1 | UQCRC1 | 0.928 | 0.836 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| MT-CO3 | UQCRC1 | 0.903 | 0.618 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| MT-CO3 | UQCRQ | 0.902 | 0.694 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| MT-CO3 | UQCRB | 0.823 | 0.666 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes