hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07848.1
Complex Portal: CPX-17928
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THRAP3 | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | 5 | UniProt NCBI |
| CAAP1 | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | 3 | UniProt NCBI |
| SPEN | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | 5 | UniProt NCBI |
| BCLAF1 | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | 5 | UniProt NCBI |
| PRMT1 | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) | 5 | UniProt NCBI |
| SRSF10 | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | 5 | UniProt NCBI |
| HNRNPCL1 | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | 5 | UniProt NCBI |
| SRSF9 | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP411 | 0.00281256194275 | 0.375 | SRSF9 PRMT1 SRSF10 | mRNA processing |
| WP:WP2916 | 0.00285973689486 | 0.25 | THRAP3 BCLAF1 | Interactome of polycomb repressive complex 2 PRC2 |
| HPA:0460182 | 0.0114646846286 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 1; cells in granular layer[>=Medium] |
| HPA:0470182 | 0.0115504501496 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 2; cells in granular layer[>=Medium] |
| HPA:0461492 | 0.0115978872891 | 0.375 | THRAP3 PRMT1 BCLAF1 | skin 1; vascular mural cells[>=Medium] |
| HPA:0250133 | 0.0160221428121 | 0.625 | THRAP3 SRSF9 SPEN PRMT1 BCLAF1 | hippocampus; neuronal cells[High] |
| HPA:0460183 | 0.023799504559 | 0.375 | THRAP3 SRSF9 BCLAF1 | skin 1; cells in granular layer[High] |
| HPA:0461491 | 0.0241036919329 | 0.375 | THRAP3 PRMT1 BCLAF1 | skin 1; vascular mural cells[>=Low] |
| HPA:0470183 | 0.0241036919329 | 0.375 | THRAP3 SRSF9 BCLAF1 | skin 2; cells in granular layer[High] |
| HPA:0471413 | 0.0253458066861 | 0.375 | THRAP3 SRSF9 BCLAF1 | skin 2; cells in spinous layer[High] |
| HPA:0471412 | 0.0255869860169 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 2; cells in spinous layer[>=Medium] |
| GO:0003723 | 0.026768592614 | 0.875 | SRSF10 THRAP3 SPEN BCLAF1 PRMT1 SRSF9 HNRNPCL1 | RNA binding |
| HPA:0460181 | 0.0298257342682 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.0301716963206 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 2; cells in granular layer[>=Low] |
| HPA:0090183 | 0.0314056492522 | 0.5 | THRAP3 SRSF9 SPEN BCLAF1 | cerebellum; cells in granular layer[High] |
| HPA:0471392 | 0.0385484416253 | 0.5 | THRAP3 SRSF9 PRMT1 BCLAF1 | skin 2; cells in basal layer[>=Medium] |
| CORUM:1731 | 0.0499436884912 | 0.125 | PRMT1 | PRMT1 complex |
| CORUM:2765 | 0.0499436884912 | 0.125 | PRMT1 | PRMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THRAP3 | BCLAF1 | 1.0 | 0.6 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| SRSF10 | THRAP3 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | ||
| SRSF9 | THRAP3 | 0.997 | 0.212 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| SRSF9 | BCLAF1 | 0.995 | 0.41 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction | |
| PRMT1 | BCLAF1 | 0.99 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | ||
| SPEN | BCLAF1 | 0.989 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| PRMT1 | THRAP3 | 0.983 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | ||
| SRSF10 | BCLAF1 | 0.982 | bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | ||
| BCLAF1 | HNRNPCL1 | 0.965 | 0.166 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| THRAP3 | CAAP1 | 0.957 | 0.35 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRSF10 | SRSF9 | 0.955 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| SPEN | SRSF9 | 0.954 | 0.11 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SRSF10 | HNRNPCL1 | 0.923 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SPEN | THRAP3 | 0.911 | 0.076 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| BCLAF1 | CAAP1 | 0.896 | 0.406 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRSF9 | HNRNPCL1 | 0.883 | 0.122 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| THRAP3 | HNRNPCL1 | 0.881 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PRMT1 | SRSF9 | 0.768 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | ||
| PRMT1 | CAAP1 | 0.343 | hein_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PRMT1 | SPEN | 0.296 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| SRSF10 | CAAP1 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SRSF9 | CAAP1 | 0.106 | 0.264 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SPEN | CAAP1 | 0.056 | 0.126 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SPEN | HNRNPCL1 | 0.026 | 0.122 | bioplex3_WMM youn_WMM WMM_only | |
| CAAP1 | HNRNPCL1 | 0.025 | 0.12 | bioplex3_WMM WMM_only | |
| SRSF10 | SPEN | 0.019 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PRMT1 | SRSF10 | 0.006 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | ||
| PRMT1 | HNRNPCL1 | 0.003 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes