hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07855.1
Complex Portal: CPX-19228
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNMT | mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | 5 | UniProt NCBI |
| RNGTT | mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] | 5 | UniProt NCBI |
| SPOP | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | 5 | UniProt NCBI |
| KPNA6 | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | 5 | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | 5 | UniProt NCBI |
| SREK1IP1 | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | 5 | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | 5 | UniProt NCBI |
| KPNA5 | Importin subunit alpha-6 (Karyopherin subunit alpha-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 7.28893023927e-06 | 0.5 | NUP50 KPNA5 KPNA6 KPNA1 | Nucleocytoplasmic transport |
| REAC:R-HSA-162587 | 0.000123441958688 | 0.5 | KPNA1 NUP50 RNMT RNGTT | HIV Life Cycle |
| REAC:R-HSA-168276 | 0.000176426072101 | 0.375 | KPNA5 KPNA1 NUP50 | NS1 Mediated Effects on Host Pathways |
| GO:0042564 | 0.00045145282213 | 0.375 | KPNA5 KPNA6 KPNA1 | NLS-dependent protein nuclear import complex |
| REAC:R-HSA-162906 | 0.00072268478922 | 0.5 | KPNA1 NUP50 RNMT RNGTT | HIV Infection |
| GO:0031074 | 0.000886327111509 | 0.375 | KPNA5 KPNA6 KPNA1 | nucleocytoplasmic transport complex |
| REAC:R-HSA-1169408 | 0.00103131007969 | 0.375 | KPNA5 KPNA1 NUP50 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.00134205528321 | 0.375 | KPNA5 KPNA1 NUP50 | Antiviral mechanism by IFN-stimulated genes |
| KEGG:05164 | 0.00250470960938 | 0.375 | KPNA5 KPNA6 KPNA1 | Influenza A |
| REAC:R-HSA-9824446 | 0.00267983185965 | 0.625 | KPNA1 KPNA5 NUP50 RNMT RNGTT | Viral Infection Pathways |
| WP:WP411 | 0.00281256194275 | 0.375 | SPOP RNMT RNGTT | mRNA processing |
| GO:0061608 | 0.00300428100757 | 0.375 | KPNA5 KPNA6 KPNA1 | nuclear import signal receptor activity |
| KEGG:05207 | 0.00362384058316 | 0.375 | KPNA5 KPNA6 KPNA1 | Chemical carcinogenesis - receptor activation |
| GO:0006607 | 0.0043754188034 | 0.375 | KPNA5 KPNA6 KPNA1 | NLS-bearing protein import into nucleus |
| REAC:R-HSA-5663205 | 0.00732097255999 | 0.625 | KPNA1 KPNA5 NUP50 RNMT RNGTT | Infectious disease |
| REAC:R-HSA-162599 | 0.00793113777729 | 0.375 | NUP50 RNMT RNGTT | Late Phase of HIV Life Cycle |
| GO:0008139 | 0.00824905178996 | 0.375 | KPNA5 KPNA6 KPNA1 | nuclear localization sequence binding |
| GO:0006606 | 0.00828529370557 | 0.5 | NUP50 KPNA5 KPNA6 KPNA1 | protein import into nucleus |
| GO:0051170 | 0.0100133115528 | 0.5 | NUP50 KPNA5 KPNA6 KPNA1 | import into nucleus |
| REAC:R-HSA-168255 | 0.0116817430051 | 0.375 | KPNA5 KPNA1 NUP50 | Influenza Infection |
| GO:0140142 | 0.0156477314671 | 0.375 | KPNA5 KPNA6 KPNA1 | nucleocytoplasmic carrier activity |
| REAC:R-HSA-167160 | 0.0180115696713 | 0.25 | RNMT RNGTT | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 0.0180115696713 | 0.25 | RNMT RNGTT | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-913531 | 0.0192389562496 | 0.375 | KPNA5 KPNA1 NUP50 | Interferon Signaling |
| REAC:R-HSA-72086 | 0.0209373692109 | 0.25 | RNMT RNGTT | mRNA Capping |
| REAC:R-HSA-168271 | 0.0224821270291 | 0.25 | KPNA1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 0.0257351328695 | 0.25 | KPNA1 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-176033 | 0.0310226901604 | 0.25 | KPNA1 NUP50 | Interactions of Vpr with host cellular proteins |
| GO:0005048 | 0.0487399472212 | 0.375 | KPNA5 KPNA6 KPNA1 | signal sequence binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KPNA1 | KPNA6 | 1.0 | 0.458 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| KPNA1 | NUP50 | 0.999 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NUP50 | KPNA6 | 0.999 | 0.222 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NUP50 | KPNA5 | 0.998 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| RNMT | KPNA6 | 0.998 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SREK1IP1 | KPNA1 | 0.997 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SPOP | NUP50 | 0.997 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| KPNA1 | RNMT | 0.997 | 0.118 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RNMT | KPNA5 | 0.997 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SREK1IP1 | KPNA6 | 0.994 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPOP | KPNA5 | 0.994 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KPNA1 | KPNA5 | 0.988 | 0.24 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| RNGTT | NUP50 | 0.982 | 0.206 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM | |
| RNGTT | KPNA1 | 0.98 | 0.084 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNMT | NUP50 | 0.97 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| KPNA5 | KPNA6 | 0.967 | 0.23 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SREK1IP1 | KPNA5 | 0.962 | 0.1 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KPNA1 | SPOP | 0.701 | 0.14 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RNGTT | KPNA5 | 0.612 | 0.176 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNGTT | SPOP | 0.586 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNGTT | KPNA6 | 0.559 | 0.166 |
mutually_exclusive (P52294)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SPOP | KPNA6 | 0.247 | 0.344 | bioplex_WMM bioplex3_WMM WMM_only | |
| SREK1IP1 | NUP50 | 0.177 | 0.13 |
mutually_exclusive (O15131)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RNGTT | RNMT | 0.159 | 0.108 |
mutually_exclusive (O15131)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SPOP | RNMT | 0.097 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | |
| SREK1IP1 | RNMT | 0.002 | 0.05 |
mutually_exclusive (O15131)
|
bioplex3_HCT116 WMM_only |
Related Complexes