hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07859.1
Complex Portal: CPX-15149
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| DCUN1D1 | DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 4.09070097144e-05 | 0.666666666667 | PIP4K2C PIP4K2B | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 0.00024538606603 | 0.666666666667 | PIP4K2C PIP4K2B | PI5P Regulates TP53 Acetylation |
| WP:WP5411 | 0.000973512535349 | 0.666666666667 | PIP4K2C PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 0.000973512535349 | 0.666666666667 | PIP4K2C PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 0.00158324752529 | 0.666666666667 | PIP4K2C PIP4K2B | Inositol phosphate metabolism |
| KEGG:04070 | 0.00271491421694 | 0.666666666667 | PIP4K2C PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6804758 | 0.00296224002415 | 0.666666666667 | PIP4K2C PIP4K2B | Regulation of TP53 Activity through Acetylation |
| GO:0016309 | 0.00421361424067 | 0.666666666667 | PIP4K2C PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 0.00421361424067 | 0.666666666667 | PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 0.00421361424067 | 0.666666666667 | PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-1660499 | 0.00735562020533 | 0.666666666667 | PIP4K2C PIP4K2B | Synthesis of PIPs at the plasma membrane |
| WP:WP51 | 0.00915401629696 | 0.666666666667 | PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| KEGG:04810 | 0.01431202154 | 0.666666666667 | PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| REAC:R-HSA-1483255 | 0.017372320015 | 0.666666666667 | PIP4K2C PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0183561585619 | 0.666666666667 | PIP4K2C PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.0220121799777 | 0.666666666667 | PIP4K2C PIP4K2B | Negative regulation of the PI3K/AKT network |
| GO:0016308 | 0.0393180950424 | 0.666666666667 | PIP4K2C PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DCUN1D1 | PIP4K2C | 0.969 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| PIP4K2B | DCUN1D1 | 0.343 | 0.054 | bioplex3_WMM WMM_only |
Related Complexes