hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07867.1
Complex Portal: CPX-18737
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) | 5 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| VWA8 | von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2) | 5 | UniProt NCBI |
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) | 5 | UniProt NCBI |
| ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 2.80233355908e-09 | 0.6 | GATC QRSL1 GATB | GATB-GATC-QRSL1 complex |
| GO:0050567 | 9.61200410764e-07 | 0.6 | GATC QRSL1 GATB | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 9.61200410764e-07 | 0.6 | GATC QRSL1 GATB | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 9.61200410764e-07 | 0.6 | GATC QRSL1 GATB | glutaminyl-tRNAGln biosynthesis via transamidation |
| KEGG:00970 | 1.14694346097e-05 | 0.6 | GATC QRSL1 GATB | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 3.41537536211e-05 | 0.6 | GATC QRSL1 GATB | Decreased circulating cortisol level |
| GO:0016884 | 8.06911104389e-05 | 0.6 | GATC QRSL1 GATB | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| HP:0008207 | 0.000198995738245 | 0.6 | GATC QRSL1 GATB | Primary adrenal insufficiency |
| HP:0011731 | 0.000241447043353 | 0.6 | GATC QRSL1 GATB | Abnormality of circulating cortisol level |
| HP:0012111 | 0.00025683213063 | 0.6 | GATC QRSL1 GATB | Abnormality of circulating glucocorticoid level |
| HP:0001790 | 0.000425593167024 | 0.6 | GATC QRSL1 GATB | Nonimmune hydrops fetalis |
| HP:0000846 | 0.000918726168333 | 0.6 | GATC QRSL1 GATB | Adrenal insufficiency |
| HP:0011733 | 0.00230478017415 | 0.6 | GATC QRSL1 GATB | Abnormality of adrenal physiology |
| HP:0001789 | 0.00273423564762 | 0.6 | GATC QRSL1 GATB | Hydrops fetalis |
| HP:0001622 | 0.00619327795747 | 0.6 | GATC QRSL1 GATB | Premature birth |
| GO:0016879 | 0.0094606249379 | 0.6 | GATC QRSL1 GATB | ligase activity, forming carbon-nitrogen bonds |
| GO:0043039 | 0.0102064666638 | 0.6 | GATC QRSL1 GATB | tRNA aminoacylation |
| GO:0043038 | 0.0102064666638 | 0.6 | GATC QRSL1 GATB | amino acid activation |
| HP:0000834 | 0.0104114042184 | 0.6 | GATC QRSL1 GATB | Abnormality of the adrenal glands |
| HP:0003128 | 0.0117509702765 | 0.6 | GATC QRSL1 GATB | Lactic acidosis |
| KEGG:01100 | 0.0139298332568 | 0.8 | GATB GATC COQ6 QRSL1 | Metabolic pathways |
| HP:0001943 | 0.0231575360078 | 0.6 | GATC QRSL1 GATB | Hypoglycemia |
| HP:0003236 | 0.0367035812988 | 0.6 | GATC QRSL1 GATB | Elevated circulating creatine kinase concentration |
| HP:0034058 | 0.0379870505578 | 0.6 | GATC QRSL1 GATB | Abnormal fetal morphology |
| HP:0011015 | 0.0424786634528 | 0.6 | GATC QRSL1 GATB | Abnormal blood glucose concentration |
| HP:0040081 | 0.0429461819912 | 0.6 | GATC QRSL1 GATB | Abnormal circulating creatine kinase concentration |
| HP:0011021 | 0.044369092363 | 0.6 | GATC QRSL1 GATB | Abnormality of circulating enzyme level |
| HP:0011924 | 0.0448666137641 | 0.4 | GATC QRSL1 | Decreased activity of mitochondrial complex III |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 |
mutually_exclusive (O75879)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GATC | GATB | 0.999 | 0.764 |
mutually_exclusive (Q9H0R6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | GATB | 0.999 | 0.296 |
mutually_exclusive (O43716)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| QRSL1 | COQ6 | 0.99 | 0.014 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| QRSL1 | ALDH4A1 | 0.968 | 0.02 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| VWA8 | QRSL1 | 0.964 | 0.108 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| COQ6 | GATB | 0.613 | 0.028 | bioplex3_WMM WMM_only | |
| VWA8 | GATB | 0.512 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| VWA8 | COQ6 | 0.455 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| GATB | ALDH4A1 | 0.448 | 0.046 | bioplex3_WMM WMM_only | |
| COQ6 | ALDH4A1 | 0.348 | 0.07 | bioplex3_WMM WMM_only | |
| GATC | COQ6 | 0.22 | 0.044 |
mutually_exclusive (Q9H0R6)
|
bioplex3_WMM WMM_only |
| VWA8 | GATC | 0.215 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VWA8 | ALDH4A1 | 0.211 | 0.102 | bioplex3_WMM WMM_only | |
| GATC | ALDH4A1 | 0.188 | 0.03 |
mutually_exclusive (Q9H0R6)
|
bioplex3_WMM WMM_only |
Related Complexes