hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07869.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EYA1 | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX1 | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7363 | 1.70876175213e-06 | 1.0 | SIX1 EYA1 | EYA1-SIX1 complex |
| HP:0009798 | 2.05051410255e-05 | 1.0 | SIX1 EYA1 | Euthyroid goiter |
| HP:0011388 | 2.05051410255e-05 | 1.0 | SIX1 EYA1 | Enlarged cochlear aqueduct |
| HP:0004458 | 2.05051410255e-05 | 1.0 | SIX1 EYA1 | Dilatated internal auditory canal |
| HP:0100274 | 3.41752350426e-05 | 1.0 | SIX1 EYA1 | Gustatory lacrimation |
| HP:0009796 | 5.12628525639e-05 | 1.0 | SIX1 EYA1 | Branchial cyst |
| HP:0000376 | 7.17679935894e-05 | 1.0 | SIX1 EYA1 | Incomplete partition of the cochlea type II |
| HP:0008586 | 7.17679935894e-05 | 1.0 | SIX1 EYA1 | Hypoplasia of the cochlea |
| HP:0011387 | 7.17679935894e-05 | 1.0 | SIX1 EYA1 | Enlarged vestibular aqueduct |
| HP:0009797 | 9.56906581192e-05 | 1.0 | SIX1 EYA1 | Cholesteatoma |
| HP:0004712 | 9.56906581192e-05 | 1.0 | SIX1 EYA1 | Renal malrotation |
| HP:0011373 | 9.56906581192e-05 | 1.0 | SIX1 EYA1 | Incomplete partition of the cochlea |
| HP:0011395 | 9.56906581192e-05 | 1.0 | SIX1 EYA1 | Aplasia/Hypoplasia of the cochlea |
| HP:0100799 | 9.56906581192e-05 | 1.0 | SIX1 EYA1 | Neoplasm of the middle ear |
| HP:0008774 | 0.000123030846153 | 1.0 | SIX1 EYA1 | Aplasia/Hypoplasia of the inner ear |
| HP:0008554 | 0.000123030846153 | 1.0 | SIX1 EYA1 | Cochlear malformation |
| HP:0009795 | 0.000153788557692 | 1.0 | SIX1 EYA1 | Branchial fistula |
| HP:0007925 | 0.000153788557692 | 1.0 | SIX1 EYA1 | Lacrimal duct aplasia |
| HP:0011094 | 0.000153788557692 | 1.0 | SIX1 EYA1 | Increased overbite |
| HP:0000799 | 0.000153788557692 | 1.0 | SIX1 EYA1 | Renal steatosis |
| HP:0100267 | 0.000187963792734 | 1.0 | SIX1 EYA1 | Lip pit |
| WP:WP4823 | 0.000238782367243 | 1.0 | SIX1 EYA1 | Genes controlling nephrogenesis |
| HP:0007678 | 0.000310994638887 | 1.0 | SIX1 EYA1 | Lacrimal duct stenosis |
| WP:WP5053 | 0.000460113616736 | 1.0 | SIX1 EYA1 | Development of ureteric collection system |
| WP:WP5236 | 0.000460113616736 | 1.0 | SIX1 EYA1 | Markers of kidney cell lineage |
| HP:0009794 | 0.000522881096151 | 1.0 | SIX1 EYA1 | Branchial anomaly |
| HP:0004452 | 0.000522881096151 | 1.0 | SIX1 EYA1 | Abnormality of the middle ear ossicles |
| HP:0011384 | 0.000584396519228 | 1.0 | SIX1 EYA1 | Abnormality of the internal auditory canal |
| HP:0000074 | 0.000584396519228 | 1.0 | SIX1 EYA1 | Ureteropelvic junction obstruction |
| HP:0012780 | 0.000584396519228 | 1.0 | SIX1 EYA1 | Neoplasm of the ear |
| HP:0011376 | 0.00111069513888 | 1.0 | SIX1 EYA1 | Abnormal morphology of the vestibule of the inner ear |
| HP:0008609 | 0.00111069513888 | 1.0 | SIX1 EYA1 | Abnormal middle ear morphology |
| HP:0000375 | 0.00119955074999 | 1.0 | SIX1 EYA1 | Abnormal cochlea morphology |
| HP:0000071 | 0.00119955074999 | 1.0 | SIX1 EYA1 | Ureteral stenosis |
| HP:0000579 | 0.00138751454273 | 1.0 | SIX1 EYA1 | Nasolacrimal duct obstruction |
| HP:0004742 | 0.00138751454273 | 1.0 | SIX1 EYA1 | Abnormal renal collecting system morphology |
| HP:0000402 | 0.00148662272435 | 1.0 | SIX1 EYA1 | Stenosis of the external auditory canal |
| HP:0006000 | 0.00180445241025 | 1.0 | SIX1 EYA1 | Ureteral obstruction |
| HP:0000410 | 0.00180445241025 | 1.0 | SIX1 EYA1 | Mixed hearing impairment |
| KEGG:05202 | 0.00194026930354 | 1.0 | SIX1 EYA1 | Transcriptional misregulation in cancer |
| HP:0011481 | 0.00280236927349 | 1.0 | SIX1 EYA1 | Abnormal lacrimal duct morphology |
| HP:0004467 | 0.00323297723503 | 1.0 | SIX1 EYA1 | Preauricular pit |
| HP:0000853 | 0.00338334826922 | 1.0 | SIX1 EYA1 | Goiter |
| HP:0100277 | 0.0036943429081 | 1.0 | SIX1 EYA1 | Periauricular skin pits |
| HP:0000113 | 0.00401900764101 | 1.0 | SIX1 EYA1 | Polycystic kidney dysplasia |
| HP:0000413 | 0.00418646629272 | 1.0 | SIX1 EYA1 | Atresia of the external auditory canal |
| HP:0000378 | 0.00625406801279 | 1.0 | SIX1 EYA1 | Cupped ear |
| HP:0100276 | 0.00625406801279 | 1.0 | SIX1 EYA1 | Skin pit |
| HP:0000614 | 0.00688972738458 | 1.0 | SIX1 EYA1 | Abnormal nasolacrimal system morphology |
| HP:0000110 | 0.00710844888886 | 1.0 | SIX1 EYA1 | Renal dysplasia |
| HP:0011390 | 0.00710844888886 | 1.0 | SIX1 EYA1 | Abnormal inner ear morphology |
| HP:0000384 | 0.00755614446791 | 1.0 | SIX1 EYA1 | Preauricular skin tag |
| HP:0011342 | 0.00755614446791 | 1.0 | SIX1 EYA1 | Mild global developmental delay |
| HP:0001374 | 0.00849254590808 | 1.0 | SIX1 EYA1 | Congenital hip dislocation |
| HP:0000359 | 0.009230730985 | 1.0 | SIX1 EYA1 | Abnormality of the inner ear |
| HP:0008572 | 0.00948362772432 | 1.0 | SIX1 EYA1 | External ear malformation |
| HP:0000632 | 0.00973994198714 | 1.0 | SIX1 EYA1 | Lacrimation abnormality |
| HP:0000372 | 0.00999967377346 | 1.0 | SIX1 EYA1 | Abnormality of the auditory canal |
| HP:0010609 | 0.0105293899166 | 1.0 | SIX1 EYA1 | Skin tags |
| HP:0000003 | 0.011629832485 | 1.0 | SIX1 EYA1 | Multicystic kidney dysplasia |
| HP:0000122 | 0.0119134869358 | 1.0 | SIX1 EYA1 | Unilateral renal agenesis |
| HP:0000383 | 0.0152592424465 | 1.0 | SIX1 EYA1 | Abnormal periauricular region morphology |
| HP:0000275 | 0.0162434892157 | 1.0 | SIX1 EYA1 | Narrow face |
| HP:0003829 | 0.0256416788524 | 1.0 | SIX1 EYA1 | Typified by incomplete penetrance |
| HP:0000324 | 0.0256416788524 | 1.0 | SIX1 EYA1 | Facial asymmetry |
| HP:0000274 | 0.0260620342435 | 1.0 | SIX1 EYA1 | Small face |
| HP:0002566 | 0.0277776310426 | 1.0 | SIX1 EYA1 | Intestinal malrotation |
| HP:0000193 | 0.0332525036964 | 1.0 | SIX1 EYA1 | Bifid uvula |
| HP:0011772 | 0.0392194997349 | 1.0 | SIX1 EYA1 | Abnormal thyroid morphology |
| HP:0000691 | 0.0418509928331 | 1.0 | SIX1 EYA1 | Microdontia |
| HP:0010628 | 0.0423875440233 | 1.0 | SIX1 EYA1 | Facial palsy |
| HP:0010827 | 0.042927512737 | 1.0 | SIX1 EYA1 | Abnormal seventh cranial physiology |
| HP:0008551 | 0.0440177027348 | 1.0 | SIX1 EYA1 | Microtia |
| HP:0000172 | 0.0479410197177 | 1.0 | SIX1 EYA1 | Abnormal uvula morphology |
| CORUM:7364 | 0.0499419797295 | 0.5 | EYA1 | EYA1-SIX2 complex |
| HP:0002710 | 0.0499436884913 | 0.5 | SIX1 | Commissural lip pit |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EYA1 | SIX1 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes