hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07872.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MPDZ | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| AMOT | Angiomotin | 5 | UniProt NCBI |
| PALS1 | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | 5 | UniProt NCBI |
| PATJ | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | 5 | UniProt NCBI |
| AMOTL1 | Angiomotin-like protein 1 | 5 | UniProt NCBI |
| NF2 | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 1.51295136123e-18 | 0.857142857143 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| KEGG:04530 | 3.15558911241e-13 | 1.0 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 NF2 | Tight junction |
| GO:0043296 | 7.74476915066e-09 | 0.857142857143 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 | apical junction complex |
| GO:0005911 | 7.86865937855e-08 | 1.0 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 NF2 | cell-cell junction |
| CORUM:846 | 3.92905941962e-07 | 0.428571428571 | PATJ AMOT PALS1 | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| GO:0005923 | 8.61211838165e-07 | 0.714285714286 | AMOTL1 AMOTL2 PATJ MPDZ AMOT | bicellular tight junction |
| GO:0070160 | 2.27164761465e-06 | 0.714285714286 | AMOTL1 AMOTL2 PATJ MPDZ AMOT | tight junction |
| GO:0003365 | 3.36420143768e-06 | 0.428571428571 | AMOTL2 AMOT AMOTL1 | establishment of cell polarity involved in ameboidal cell migration |
| GO:0070161 | 1.11756958291e-05 | 1.0 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 NF2 | anchoring junction |
| KEGG:04390 | 1.70572201178e-05 | 0.571428571429 | PATJ NF2 AMOT PALS1 | Hippo signaling pathway |
| CORUM:460 | 6.1565588648e-05 | 0.285714285714 | PALS1 PATJ | CRB1-MPP5-INADL complex |
| GO:0035329 | 0.000102438985779 | 0.571428571429 | AMOTL2 NF2 AMOT AMOTL1 | hippo signaling |
| GO:0007163 | 0.00013411944099 | 0.714285714286 | AMOTL1 AMOTL2 PATJ AMOT PALS1 | establishment or maintenance of cell polarity |
| REAC:R-HSA-9705677 | 0.000380832872101 | 0.285714285714 | PALS1 PATJ | SARS-CoV-2 targets PDZ proteins in cell-cell junction |
| GO:0030054 | 0.000952363989281 | 1.0 | PATJ AMOTL2 AMOTL1 AMOT MPDZ PALS1 NF2 | cell junction |
| GO:0030010 | 0.00355458399407 | 0.571428571429 | AMOTL1 AMOTL2 AMOT PATJ | establishment of cell polarity |
| REAC:R-HSA-420029 | 0.00398963152505 | 0.285714285714 | PALS1 PATJ | Tight junction interactions |
| REAC:R-HSA-2028269 | 0.0064914715634 | 0.285714285714 | AMOTL2 AMOTL1 | Signaling by Hippo |
| REAC:R-HSA-421270 | 0.037359797124 | 0.285714285714 | PALS1 PATJ | Cell-cell junction organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PALS1 | AMOTL1 | 0.999 | 0.094 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| AMOTL2 | PALS1 | 0.999 | 0.04 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AMOTL2 | NF2 | 0.998 | 0.114 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| AMOTL1 | NF2 | 0.997 | 0.178 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PALS1 | MPDZ | 0.996 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| AMOT | AMOTL1 | 0.995 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM |
| MPDZ | AMOTL1 | 0.991 | 0.078 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| AMOTL2 | MPDZ | 0.987 | 0.07 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| AMOT | MPDZ | 0.983 | 0.0822222222222 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PALS1 | NF2 | 0.981 | 0.038 | hein_WMM bioplex3_WMM WMM_only |
| AMOTL2 | AMOTL1 | 0.976 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PALS1 | AMOT | 0.973 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| AMOT | NF2 | 0.969 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MPDZ | NF2 | 0.953 | 0.024 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| AMOTL2 | AMOT | 0.268 | 0.206 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes