hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07877.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTCH1 | Protein patched homolog 1 (PTC) (PTC1) | 5 | UniProt NCBI |
| ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)] | 5 | UniProt NCBI |
| PLXND1 | Plexin-D1 | 5 | UniProt NCBI |
| GUCD1 | Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) | 5 | UniProt NCBI |
| ST8SIA6 | Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI) | 5 | UniProt NCBI |
| CHST3 | Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (C6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0010660 | 0.000160619133799 | 0.5 | ENPP1 PTCH1 CHST3 | Abnormal hand bone ossification |
| HP:0003043 | 0.00189631547552 | 0.5 | ENPP1 PTCH1 CHST3 | Abnormal shoulder morphology |
| HP:0001679 | 0.0032006170466 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormal aortic morphology |
| HP:0005914 | 0.00627840452922 | 0.5 | PLXND1 PTCH1 CHST3 | Aplasia/Hypoplasia involving the metacarpal bones |
| HP:0001642 | 0.0069909928987 | 0.5 | CHST3 ENPP1 PLXND1 | Pulmonic stenosis |
| HP:0003336 | 0.00717714082957 | 0.5 | ENPP1 PTCH1 CHST3 | Abnormal enchondral ossification |
| HP:0001640 | 0.00736654421907 | 0.5 | CHST3 ENPP1 PLXND1 | Cardiomegaly |
| HP:0011004 | 0.0100911739367 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormal systemic arterial morphology |
| WP:WP474 | 0.0108030732892 | 0.333333333333 | ENPP1 PTCH1 | Endochondral ossification |
| WP:WP4808 | 0.0108030732892 | 0.333333333333 | ENPP1 PTCH1 | Endochondral ossification with skeletal dysplasias |
| HP:0031654 | 0.0118805266195 | 0.5 | CHST3 ENPP1 PLXND1 | Abnormal pulmonary valve physiology |
| HP:0001714 | 0.0121446270864 | 0.5 | CHST3 ENPP1 PLXND1 | Ventricular hypertrophy |
| HP:0001633 | 0.0124125846174 | 0.5 | CHST3 ENPP1 PLXND1 | Abnormal mitral valve morphology |
| HP:0000684 | 0.0138111776458 | 0.5 | ENPP1 PTCH1 CHST3 | Delayed eruption of teeth |
| HP:0006705 | 0.0182726158894 | 0.5 | CHST3 ENPP1 PLXND1 | Abnormal atrioventricular valve morphology |
| HP:0100240 | 0.0208218734023 | 0.5 | ENPP1 PTCH1 CHST3 | Synostosis of joints |
| HP:0025668 | 0.0241353316752 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormal neck morphology |
| HP:0005916 | 0.0298537414198 | 0.5 | PLXND1 PTCH1 CHST3 | Abnormal metacarpal morphology |
| HP:0000464 | 0.0313901870845 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormality of the neck |
| HP:0030962 | 0.0339162393676 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormal morphology of the great vessels |
| HP:0006292 | 0.0376785959704 | 0.5 | ENPP1 PTCH1 CHST3 | Abnormality of dental eruption |
| HP:0011314 | 0.0401476884444 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | Abnormal long bone morphology |
| HP:0002982 | 0.0406481036194 | 0.333333333333 | ENPP1 CHST3 | Tibial bowing |
| HP:0006257 | 0.0406481036194 | 0.333333333333 | ENPP1 CHST3 | Abnormality of carpal bone ossification |
| HP:0003040 | 0.0467604957305 | 0.333333333333 | ENPP1 CHST3 | Arthropathy |
| HP:0000218 | 0.0494403483522 | 0.666666666667 | CHST3 ENPP1 PTCH1 PLXND1 | High palate |
| HP:0005106 | 0.0499762286031 | 0.333333333333 | ENPP1 CHST3 | Abnormality of the vertebral endplates |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ENPP1 | PTCH1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PTCH1 | ST8SIA6 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTCH1 | PLXND1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTCH1 | GUCD1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTCH1 | CHST3 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ENPP1 | PLXND1 | 0.805 | 0.046 | bioplex3_WMM WMM_only |
| ENPP1 | CHST3 | 0.714 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| ST8SIA6 | CHST3 | 0.628 | bioplex3_WMM WMM_only | |
| ENPP1 | ST8SIA6 | 0.586 | bioplex3_WMM WMM_only | |
| PLXND1 | ST8SIA6 | 0.468 | bioplex3_WMM WMM_only | |
| GUCD1 | CHST3 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLXND1 | CHST3 | 0.106 | 0.144 | bioplex3_WMM WMM_only |
| GUCD1 | ST8SIA6 | 0.055 | bioplex3_WMM WMM_only | |
| ENPP1 | GUCD1 | 0.047 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLXND1 | GUCD1 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes