hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07904.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
CASC3	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	5	UniProt NCBI
SDE2	Splicing regulator SDE2 (Replication stress response regulator SDE2)	5	UniProt NCBI
MAGOH	Protein mago nashi homolog	5	UniProt NCBI
PYM1	Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)	5	UniProt NCBI
MAGOHB	Protein mago nashi homolog 2	5	UniProt NCBI
RBM8A	RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:755	4.80104919782e-12	0.666666666667	PYM1 RBM8A CASC3 MAGOH	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM)
GO:0035145	8.36907803204e-10	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	exon-exon junction complex
KEGG:03015	2.58813816133e-09	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	mRNA surveillance pathway
KEGG:03013	4.40572102528e-09	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	Nucleocytoplasmic transport
GO:0000184	1.2801918285e-08	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
CORUM:744	1.87066161015e-08	0.5	RBM8A CASC3 MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:740	1.87066161015e-08	0.5	RBM8A CASC3 MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:769	1.87066161015e-08	0.5	RBM8A CASC3 MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:754	1.87066161015e-08	0.5	RBM8A CASC3 MAGOH	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14)
GO:2000622	1.30147699894e-07	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
REAC:R-HSA-72187	4.92132752099e-07	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	mRNA 3'-end processing
REAC:R-HSA-72163	5.10720654207e-07	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	mRNA Splicing - Major Pathway
REAC:R-HSA-72172	6.06851470168e-07	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	mRNA Splicing
REAC:R-HSA-73856	8.58772945408e-07	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	1.32087543833e-06	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Transport of Mature mRNA derived from an Intron-Containing Transcript
GO:1903503	1.92240082153e-06	0.5	RBM8A MAGOH MAGOHB	ATPase inhibitor complex
GO:1990501	1.92240082153e-06	0.5	RBM8A MAGOH MAGOHB	exon-exon junction subcomplex mago-y14
REAC:R-HSA-72202	2.16235704625e-06	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-72203	2.42636100074e-06	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	Processing of Capped Intron-Containing Pre-mRNA
GO:0000956	7.20360031281e-06	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	nuclear-transcribed mRNA catabolic process
REAC:R-HSA-975957	9.56649817153e-06	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REAC:R-HSA-927802	9.56649817153e-06	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Nonsense-Mediated Decay (NMD)
CORUM:773	1.70876175213e-05	0.333333333333	MAGOH RBM8A	Y14-Magoh complex
CORUM:763	1.70876175213e-05	0.333333333333	MAGOH RBM8A	Y14-Magoh complex
REAC:R-HSA-9010553	4.34871873477e-05	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Regulation of expression of SLITs and ROBOs
CORUM:1293	5.12534978153e-05	0.333333333333	MAGOH RBM8A	IPO13-RBM8A-MAGOH complex
REAC:R-HSA-376176	0.0001116925196	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Signaling by ROBO receptors
GO:0016071	0.000144505202752	1.0	SDE2 PYM1 MAGOH MAGOHB CASC3 RBM8A	mRNA metabolic process
GO:0006402	0.000146021972444	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	mRNA catabolic process
REAC:R-HSA-8953854	0.000234756919958	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	Metabolism of RNA
CORUM:6742	0.00025612721106	0.333333333333	MAGOH RBM8A	SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex
GO:0006406	0.000282532632952	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	mRNA export from nucleus
CORUM:785	0.000358512652571	0.333333333333	MAGOH RBM8A	Exon junction complex
GO:0006401	0.000399946966982	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	RNA catabolic process
GO:0051028	0.000403034704454	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	mRNA transport
GO:0071006	0.00042234232358	0.5	RBM8A CASC3 MAGOHB	U2-type catalytic step 1 spliceosome
GO:0071012	0.00042234232358	0.5	RBM8A CASC3 MAGOHB	catalytic step 1 spliceosome
GO:0000398	0.000568720447402	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	mRNA splicing, via spliceosome
GO:0000377	0.000568720447402	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000375	0.00061299016503	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	RNA splicing, via transesterification reactions
KEGG:03040	0.000620541886073	0.5	RBM8A MAGOH MAGOHB	Spliceosome
GO:0006405	0.000792088897246	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	RNA export from nucleus
GO:0006397	0.0018087286159	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	mRNA processing
GO:0050658	0.0020139313777	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	RNA transport
GO:0050657	0.0020139313777	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	nucleic acid transport
GO:0051236	0.00225224503687	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	establishment of RNA localization
GO:0008380	0.00281759779491	0.833333333333	MAGOHB RBM8A CASC3 MAGOH SDE2	RNA splicing
REAC:R-HSA-422475	0.0030564769327	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Axon guidance
REAC:R-HSA-9675108	0.00353370301704	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Nervous system development
GO:0034655	0.00392183535385	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	nucleobase-containing compound catabolic process
GO:0046700	0.00554260195408	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	heterocycle catabolic process
GO:0044270	0.00560905260188	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	cellular nitrogen compound catabolic process
GO:0019439	0.0059509096118	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	aromatic compound catabolic process
GO:0006403	0.00596067597779	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	RNA localization
GO:0051168	0.0063111355837	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	nuclear export
GO:1901361	0.00715811587239	0.833333333333	PYM1 MAGOHB RBM8A CASC3 MAGOH	organic cyclic compound catabolic process
GO:0015931	0.00766019783716	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	nucleobase-containing compound transport
GO:0061013	0.00852183891996	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	regulation of mRNA catabolic process
WP:WP5362	0.0117481700727	0.333333333333	MAGOH PYM1	TAR syndrome
GO:0005681	0.013015960717	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	spliceosomal complex
HPA:0010012	0.0255999995903	0.833333333333	PYM1 RBM8A CASC3 MAGOH SDE2	adipose tissue; adipocytes[>=Medium]
REAC:R-HSA-1266738	0.02903341132	0.666666666667	MAGOHB RBM8A CASC3 MAGOH	Developmental Biology
HPA:0080122	0.0298293307368	0.833333333333	PYM1 RBM8A CASC3 MAGOH SDE2	caudate; glial cells[>=Medium]
HPA:0330223	0.0367571725092	0.666666666667	PYM1 RBM8A SDE2 MAGOH	oral mucosa; squamous epithelial cells[High]
GO:0003723	0.0382588428658	1.0	SDE2 PYM1 MAGOH MAGOHB CASC3 RBM8A	RNA binding
CORUM:1181	0.0493179573456	0.333333333333	MAGOH RBM8A	C complex spliceosome

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
MAGOH	RBM8A	1.0		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM
MAGOH	PYM1	0.997		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
RBM8A	PYM1	0.996	0.096	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
MAGOH	MAGOHB	0.994		hein_WMM bioplex3_WMM hein () gupta_WMM
MAGOH	CASC3	0.993		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
RBM8A	SDE2	0.991	0.202	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
PYM1	CASC3	0.989	0.104	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
RBM8A	MAGOHB	0.983	0.946	hein_WMM bioplex3_WMM hein () gupta_WMM
RBM8A	CASC3	0.982	0.706	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
PYM1	MAGOHB	0.854	0.1	hein_WMM bioplex3_WMM hein ()
MAGOH	SDE2	0.353		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
SDE2	MAGOHB	0.179	0.224	hein_WMM bioplex3_WMM WMM_only
MAGOHB	CASC3	0.139	0.518	hein_WMM bioplex3_WMM WMM_only
SDE2	PYM1	0.032	0.092	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
SDE2	CASC3	0.006	0.104	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
CASC3	huMAP3_05846.1 huMAP3_06975.1 huMAP3_07737.1 huMAP3_07904.1 huMAP3_08627.1 huMAP3_09095.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09943.1 huMAP3_10114.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11032.1 huMAP3_11073.1
SDE2	huMAP3_01288.1 huMAP3_03123.1 huMAP3_06443.1 huMAP3_07904.1 huMAP3_09149.1 huMAP3_10789.1 huMAP3_12136.1
MAGOH	huMAP3_00837.1 huMAP3_04073.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07208.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
PYM1	huMAP3_01288.1 huMAP3_02598.1 huMAP3_04073.1 huMAP3_05708.1 huMAP3_06443.1 huMAP3_07208.1 huMAP3_07733.1 huMAP3_07904.1 huMAP3_08627.1 huMAP3_09787.1 huMAP3_10789.1 huMAP3_11073.1
MAGOHB	huMAP3_01312.1 huMAP3_04073.1 huMAP3_06443.1 huMAP3_06799.1 huMAP3_07674.1 huMAP3_07904.1 huMAP3_08082.1 huMAP3_08344.1 huMAP3_09149.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_10789.1 huMAP3_11073.1
RBM8A	huMAP3_00837.1 huMAP3_01288.1 huMAP3_03123.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09149.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07904.1