hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07904.1
Complex Portal: CPX-18617
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASC3 | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | 5 | UniProt NCBI |
| SDE2 | Splicing regulator SDE2 (Replication stress response regulator SDE2) | 5 | UniProt NCBI |
| MAGOH | Protein mago nashi homolog | 5 | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | 5 | UniProt NCBI |
| MAGOHB | Protein mago nashi homolog 2 | 5 | UniProt NCBI |
| RBM8A | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:755 | 4.80104919782e-12 | 0.666666666667 | PYM1 RBM8A CASC3 MAGOH | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM) |
| GO:0035145 | 8.36907803204e-10 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | exon-exon junction complex |
| KEGG:03015 | 2.58813816133e-09 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | mRNA surveillance pathway |
| KEGG:03013 | 4.40572102528e-09 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | Nucleocytoplasmic transport |
| GO:0000184 | 1.2801918285e-08 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| CORUM:744 | 1.87066161015e-08 | 0.5 | RBM8A CASC3 MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:740 | 1.87066161015e-08 | 0.5 | RBM8A CASC3 MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:769 | 1.87066161015e-08 | 0.5 | RBM8A CASC3 MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:754 | 1.87066161015e-08 | 0.5 | RBM8A CASC3 MAGOH | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14) |
| GO:2000622 | 1.30147699894e-07 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| REAC:R-HSA-72187 | 4.92132752099e-07 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | mRNA 3'-end processing |
| REAC:R-HSA-72163 | 5.10720654207e-07 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 6.06851470168e-07 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | mRNA Splicing |
| REAC:R-HSA-73856 | 8.58772945408e-07 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 1.32087543833e-06 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:1903503 | 1.92240082153e-06 | 0.5 | MAGOHB MAGOH RBM8A | ATPase inhibitor complex |
| GO:1990501 | 1.92240082153e-06 | 0.5 | MAGOHB MAGOH RBM8A | exon-exon junction subcomplex mago-y14 |
| REAC:R-HSA-72202 | 2.16235704625e-06 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-72203 | 2.42636100074e-06 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000956 | 7.20360031281e-06 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-975957 | 9.56649817153e-06 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 9.56649817153e-06 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Nonsense-Mediated Decay (NMD) |
| CORUM:773 | 1.70876175213e-05 | 0.333333333333 | RBM8A MAGOH | Y14-Magoh complex |
| CORUM:763 | 1.70876175213e-05 | 0.333333333333 | RBM8A MAGOH | Y14-Magoh complex |
| REAC:R-HSA-9010553 | 4.34871873477e-05 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Regulation of expression of SLITs and ROBOs |
| CORUM:1293 | 5.12534978153e-05 | 0.333333333333 | RBM8A MAGOH | IPO13-RBM8A-MAGOH complex |
| REAC:R-HSA-376176 | 0.0001116925196 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Signaling by ROBO receptors |
| GO:0016071 | 0.000144505202752 | 1.0 | RBM8A CASC3 PYM1 MAGOHB MAGOH SDE2 | mRNA metabolic process |
| GO:0006402 | 0.000146021972444 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | mRNA catabolic process |
| REAC:R-HSA-8953854 | 0.000234756919958 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | Metabolism of RNA |
| CORUM:6742 | 0.00025612721106 | 0.333333333333 | RBM8A MAGOH | SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex |
| GO:0006406 | 0.000282532632952 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | mRNA export from nucleus |
| CORUM:785 | 0.000358512652571 | 0.333333333333 | RBM8A MAGOH | Exon junction complex |
| GO:0006401 | 0.000399946966982 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | RNA catabolic process |
| GO:0051028 | 0.000403034704454 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | mRNA transport |
| GO:0071006 | 0.00042234232358 | 0.5 | MAGOHB CASC3 RBM8A | U2-type catalytic step 1 spliceosome |
| GO:0071012 | 0.00042234232358 | 0.5 | MAGOHB CASC3 RBM8A | catalytic step 1 spliceosome |
| GO:0000398 | 0.000568720447402 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.000568720447402 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00061299016503 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | RNA splicing, via transesterification reactions |
| KEGG:03040 | 0.000620541886073 | 0.5 | MAGOHB MAGOH RBM8A | Spliceosome |
| GO:0006405 | 0.000792088897246 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | RNA export from nucleus |
| GO:0006397 | 0.0018087286159 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | mRNA processing |
| GO:0050658 | 0.0020139313777 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | RNA transport |
| GO:0050657 | 0.0020139313777 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | nucleic acid transport |
| GO:0051236 | 0.00225224503687 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | establishment of RNA localization |
| GO:0008380 | 0.00281759779491 | 0.833333333333 | MAGOHB RBM8A CASC3 MAGOH SDE2 | RNA splicing |
| REAC:R-HSA-422475 | 0.0030564769327 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Axon guidance |
| REAC:R-HSA-9675108 | 0.00353370301704 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Nervous system development |
| GO:0034655 | 0.00392183535385 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | nucleobase-containing compound catabolic process |
| GO:0046700 | 0.00554260195408 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | heterocycle catabolic process |
| GO:0044270 | 0.00560905260188 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.0059509096118 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | aromatic compound catabolic process |
| GO:0006403 | 0.00596067597779 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | RNA localization |
| GO:0051168 | 0.0063111355837 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | nuclear export |
| GO:1901361 | 0.00715811587239 | 0.833333333333 | PYM1 MAGOHB RBM8A CASC3 MAGOH | organic cyclic compound catabolic process |
| GO:0015931 | 0.00766019783716 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | nucleobase-containing compound transport |
| GO:0061013 | 0.00852183891996 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | regulation of mRNA catabolic process |
| WP:WP5362 | 0.0117481700727 | 0.333333333333 | MAGOH PYM1 | TAR syndrome |
| GO:0005681 | 0.013015960717 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | spliceosomal complex |
| HPA:0010012 | 0.0255999995903 | 0.833333333333 | PYM1 RBM8A CASC3 MAGOH SDE2 | adipose tissue; adipocytes[>=Medium] |
| REAC:R-HSA-1266738 | 0.02903341132 | 0.666666666667 | MAGOHB RBM8A CASC3 MAGOH | Developmental Biology |
| HPA:0080122 | 0.0298293307368 | 0.833333333333 | PYM1 RBM8A CASC3 MAGOH SDE2 | caudate; glial cells[>=Medium] |
| HPA:0330223 | 0.0367571725092 | 0.666666666667 | PYM1 RBM8A SDE2 MAGOH | oral mucosa; squamous epithelial cells[High] |
| GO:0003723 | 0.0382588428658 | 1.0 | RBM8A CASC3 PYM1 MAGOHB MAGOH SDE2 | RNA binding |
| CORUM:1181 | 0.0493179573456 | 0.333333333333 | RBM8A MAGOH | C complex spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAGOH | RBM8A | 1.0 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| MAGOH | PYM1 | 0.997 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RBM8A | PYM1 | 0.996 | 0.096 |
mutually_exclusive (Q96A72)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| MAGOH | MAGOHB | 0.994 | hein_WMM bioplex3_WMM hein () gupta_WMM | ||
| MAGOH | CASC3 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| RBM8A | SDE2 | 0.991 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| PYM1 | CASC3 | 0.989 | 0.104 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| RBM8A | MAGOHB | 0.983 | 0.946 |
mutually_exclusive (Q96J01)
structurally_consistent (dimer) |
hein_WMM bioplex3_WMM hein () gupta_WMM |
| RBM8A | CASC3 | 0.982 | 0.706 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| PYM1 | MAGOHB | 0.854 | 0.1 |
mutually_exclusive (P38919)
structurally_consistent (dimer) |
hein_WMM bioplex3_WMM hein () |
| MAGOH | SDE2 | 0.353 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| SDE2 | MAGOHB | 0.179 | 0.224 | hein_WMM bioplex3_WMM WMM_only | |
| MAGOHB | CASC3 | 0.139 | 0.518 | hein_WMM bioplex3_WMM WMM_only | |
| SDE2 | PYM1 | 0.032 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SDE2 | CASC3 | 0.006 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes