hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07905.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD51C | DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) | 5 | UniProt NCBI |
| NXPH1 | Neurexophilin-1 | 2 | UniProt NCBI |
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | 5 | UniProt NCBI |
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | 5 | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:258 | 3.83566049696e-13 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | BCDX2 complex |
| CORUM:251 | 3.83566049696e-13 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | BCDX2 complex |
| CORUM:68 | 3.83566049696e-13 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | BCDX2 complex |
| CORUM:261 | 1.91772524101e-12 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| GO:0033063 | 1.31563155046e-10 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| GO:0033061 | 1.97323122031e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | DNA recombinase mediator complex |
| REAC:R-HSA-9709603 | 4.53395842532e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9701193 | 5.39727369539e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9701192 | 5.39727369539e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704646 | 5.39727369539e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 5.39727369539e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-5693554 | 7.4870963414e-09 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| KEGG:03440 | 1.16503464997e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Homologous recombination |
| REAC:R-HSA-5693568 | 1.74513507793e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 1.97771129067e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Resolution of D-Loop Structures |
| REAC:R-HSA-5693616 | 3.50664405889e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 3.89605743335e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 3.89605743335e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 4.77117693363e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 9.02804991004e-08 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Diseases of DNA repair |
| REAC:R-HSA-5685942 | 3.06812697185e-07 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | HDR through Homologous Recombination (HRR) |
| GO:0000400 | 3.12897432326e-07 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | four-way junction DNA binding |
| REAC:R-HSA-5693567 | 3.85269753617e-06 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 4.67050314665e-06 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | Homology Directed Repair |
| GO:0000217 | 5.37501604002e-06 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | DNA secondary structure binding |
| REAC:R-HSA-5693532 | 1.05854142603e-05 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | DNA Double-Strand Break Repair |
| CORUM:262 | 1.36501667663e-05 | 0.4 | RAD51D XRCC2 | RAD51L3-XRCC2 complex |
| CORUM:260 | 1.36501667663e-05 | 0.4 | RAD51C RAD51B | RAD51B-RAD51C complex |
| CORUM:256 | 1.36501667663e-05 | 0.4 | RAD51C RAD51B | RAD51B-RAD51C complex |
| CORUM:2228 | 4.09448956317e-05 | 0.4 | RAD51D XRCC2 | BLM-RAD51L3-XRCC2 complex |
| GO:0005657 | 8.87760174517e-05 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | replication fork |
| REAC:R-HSA-73894 | 0.000150476434856 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | DNA Repair |
| GO:0051321 | 0.00309714791762 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | meiotic cell cycle |
| GO:0000724 | 0.00326030759216 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | double-strand break repair via homologous recombination |
| GO:0000725 | 0.00360584954209 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | recombinational repair |
| HP:0030406 | 0.00582689447108 | 0.4 | RAD51C RAD51D | Primary peritoneal carcinoma |
| GO:0007131 | 0.00875197805683 | 0.6 | RAD51C RAD51D RAD51B | reciprocal meiotic recombination |
| GO:0140527 | 0.00875197805683 | 0.6 | RAD51C RAD51D RAD51B | reciprocal homologous recombination |
| HP:0005522 | 0.0147751514018 | 0.4 | RAD51C XRCC2 | Pyridoxine-responsive sideroblastic anemia |
| GO:0035825 | 0.0155155487472 | 0.6 | RAD51C RAD51D RAD51B | homologous recombination |
| HP:0010469 | 0.0161800923797 | 0.4 | RAD51C XRCC2 | Absent testis |
| GO:0006310 | 0.0196468946878 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | DNA recombination |
| HP:0011027 | 0.0207761643339 | 0.4 | RAD51C RAD51D | Abnormal fallopian tube morphology |
| HP:0012848 | 0.0224351839587 | 0.4 | RAD51C XRCC2 | Small intestinal stenosis |
| HP:0010293 | 0.0224351839587 | 0.4 | RAD51C XRCC2 | Aplasia/Hypoplasia of the uvula |
| HP:0100867 | 0.0224351839587 | 0.4 | RAD51C XRCC2 | Duodenal stenosis |
| HP:0002245 | 0.0241576577336 | 0.4 | RAD51C XRCC2 | Meckel diverticulum |
| HP:0100760 | 0.0241576577336 | 0.4 | RAD51C XRCC2 | Clubbing of toes |
| HP:0100587 | 0.0277928629638 | 0.4 | RAD51C XRCC2 | Abnormal preputium morphology |
| GO:0006302 | 0.0280745884658 | 0.8 | RAD51C RAD51D XRCC2 RAD51B | double-strand break repair |
| HP:0001924 | 0.0316815705386 | 0.4 | RAD51C XRCC2 | Sideroblastic anemia |
| HP:0012125 | 0.0337209222644 | 0.4 | RAD51C RAD51D | Prostate cancer |
| HP:0100787 | 0.0337209222644 | 0.4 | RAD51C RAD51D | Prostate neoplasm |
| HP:0002984 | 0.0425110382594 | 0.4 | RAD51C XRCC2 | Hypoplasia of the radius |
| HP:0040012 | 0.0425110382594 | 0.4 | RAD51C XRCC2 | Chromosome breakage |
| HP:0001549 | 0.0425110382594 | 0.4 | RAD51C XRCC2 | Abnormal ileum morphology |
| HP:0008775 | 0.0472853555832 | 0.4 | RAD51C RAD51D | Abnormal prostate morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD51D | XRCC2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | XRCC2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | RAD51C | 0.999 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAD51D | RAD51C | 0.998 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD51D | RAD51B | 0.997 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| XRCC2 | RAD51C | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NXPH1 | RAD51C | 0.969 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes