hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07911.1
Complex Portal: CPX-12677
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NLGN3 | Neuroligin-3 (Gliotactin homolog) | 5 | UniProt NCBI |
| NLGN4X | Neuroligin-4, X-linked (Neuroligin X) (HNLX) | 5 | UniProt NCBI |
| NLGN1 | Neuroligin-1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5398 | 2.82158830257e-08 | 1.0 | NLGN1 NLGN3 NLGN4X | NRXN1 deletion syndrome |
| WP:WP4875 | 1.78287172964e-07 | 1.0 | NLGN1 NLGN3 NLGN4X | Disruption of postsynaptic signaling by CNV |
| GO:0098985 | 3.84480164306e-07 | 1.0 | NLGN1 NLGN3 NLGN4X | asymmetric, glutamatergic, excitatory synapse |
| GO:0097104 | 1.92240082153e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | postsynaptic membrane assembly |
| GO:0097105 | 5.38272230028e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | presynaptic membrane assembly |
| REAC:R-HSA-6794361 | 7.08302050262e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | Neurexins and neuroligins |
| GO:0097090 | 8.07408345042e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | presynaptic membrane organization |
| GO:0060077 | 8.07408345042e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | inhibitory synapse |
| KEGG:04514 | 9.51295867401e-06 | 1.0 | NLGN1 NLGN3 NLGN4X | Cell adhesion molecules |
| GO:0007158 | 1.15344049292e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | neuron cell-cell adhesion |
| GO:0099068 | 2.11464090368e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | postsynapse assembly |
| GO:0042043 | 2.11464090368e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | neurexin family protein binding |
| REAC:R-HSA-6794362 | 2.55418012064e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | Protein-protein interactions at synapses |
| GO:0098982 | 3.49876949518e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | GABA-ergic synapse |
| GO:0001941 | 4.37346186898e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | postsynaptic membrane organization |
| HP:0000721 | 7.59175135241e-05 | 0.666666666667 | NLGN3 NLGN4X | Lack of spontaneous play |
| HP:5200104 | 7.59175135241e-05 | 0.666666666667 | NLGN3 NLGN4X | Abnormal play |
| GO:0060076 | 7.84339535184e-05 | 1.0 | NLGN1 NLGN3 NLGN4X | excitatory synapse |
| GO:0099054 | 0.000170228592746 | 1.0 | NLGN1 NLGN3 NLGN4X | presynapse assembly |
| GO:0098815 | 0.000170228592746 | 1.0 | NLGN1 NLGN3 NLGN4X | modulation of excitatory postsynaptic potential |
| HP:0000732 | 0.000189776464884 | 0.666666666667 | NLGN3 NLGN4X | Inflexible adherence to routines |
| HP:5200130 | 0.000189776464884 | 0.666666666667 | NLGN3 NLGN4X | Insistence on sameness |
| GO:0099172 | 0.000194546963139 | 1.0 | NLGN1 NLGN3 NLGN4X | presynapse organization |
| WP:WP5420 | 0.000227067318649 | 1.0 | NLGN1 NLGN3 NLGN4X | ADHD and autism ASD linked metabolic pathways and SNP |
| HP:5200016 | 0.000265674927589 | 0.666666666667 | NLGN3 NLGN4X | Abnormal peer relationships |
| HP:0002332 | 0.000265674927589 | 0.666666666667 | NLGN3 NLGN4X | Lack of peer relationships |
| GO:0060079 | 0.000524430944113 | 1.0 | NLGN1 NLGN3 NLGN4X | excitatory postsynaptic potential |
| GO:0099565 | 0.000746852719164 | 1.0 | NLGN1 NLGN3 NLGN4X | chemical synaptic transmission, postsynaptic |
| HP:0003144 | 0.000834787835662 | 0.666666666667 | NLGN3 NLGN4X | Increased serum serotonin |
| HP:5200024 | 0.000986522412937 | 0.666666666667 | NLGN3 NLGN4X | Abnormal relationship |
| GO:0060078 | 0.00118621742692 | 1.0 | NLGN1 NLGN3 NLGN4X | regulation of postsynaptic membrane potential |
| GO:0048488 | 0.00136394338287 | 1.0 | NLGN1 NLGN3 NLGN4X | synaptic vesicle endocytosis |
| GO:0140238 | 0.00136394338287 | 1.0 | NLGN1 NLGN3 NLGN4X | presynaptic endocytosis |
| HP:0000723 | 0.00151751896202 | 0.666666666667 | NLGN3 NLGN4X | Restrictive behavior |
| GO:0097110 | 0.00155858646605 | 1.0 | NLGN1 NLGN3 NLGN4X | scaffold protein binding |
| GO:0071709 | 0.00177091563679 | 1.0 | NLGN1 NLGN3 NLGN4X | membrane assembly |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | NLGN1 NLGN3 NLGN4X | Neuronal System |
| GO:0044091 | 0.00212425290779 | 1.0 | NLGN1 NLGN3 NLGN4X | membrane biogenesis |
| GO:0036465 | 0.00238416149886 | 1.0 | NLGN1 NLGN3 NLGN4X | synaptic vesicle recycling |
| GO:0031644 | 0.00238416149886 | 1.0 | NLGN1 NLGN3 NLGN4X | regulation of nervous system process |
| GO:0098978 | 0.00460463056777 | 1.0 | NLGN1 NLGN3 NLGN4X | glutamatergic synapse |
| GO:0099173 | 0.00731242824493 | 1.0 | NLGN1 NLGN3 NLGN4X | postsynapse organization |
| GO:0098983 | 0.00842684400117 | 0.666666666667 | NLGN3 NLGN4X | symmetric, GABA-ergic, inhibitory synapse |
| GO:0007416 | 0.013733631469 | 1.0 | NLGN1 NLGN3 NLGN4X | synapse assembly |
| GO:0099504 | 0.0180186629002 | 1.0 | NLGN1 NLGN3 NLGN4X | synaptic vesicle cycle |
| HP:0000729 | 0.0190323050199 | 1.0 | NLGN1 NLGN3 NLGN4X | Autistic behavior |
| GO:0099003 | 0.019623483106 | 1.0 | NLGN1 NLGN3 NLGN4X | vesicle-mediated transport in synapse |
| GO:0032280 | 0.0210651876021 | 0.666666666667 | NLGN3 NLGN4X | symmetric synapse |
| HP:0000734 | 0.0221003701364 | 1.0 | NLGN1 NLGN3 NLGN4X | Disinhibition |
| CORUM:7344 | 0.0249718442456 | 0.333333333333 | NLGN1 | NLGN1-NRXN1 complex |
| GO:0032279 | 0.0263194935275 | 1.0 | NLGN1 NLGN3 NLGN4X | asymmetric synapse |
| GO:0098984 | 0.0298091316188 | 1.0 | NLGN1 NLGN3 NLGN4X | neuron to neuron synapse |
| GO:0071625 | 0.0393180950424 | 0.666666666667 | NLGN3 NLGN4X | vocalization behavior |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NLGN3 | NLGN1 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | NLGN4X | 0.984 |
mutually_exclusive (Q8N2Q7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN4X | NLGN1 | 0.543 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| NLGN3 | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |
| NLGN4X | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |
| NLGN1 | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |