hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07914.1
Complex Portal: CPX-16275
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRTN3 | Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen) | 5 | UniProt NCBI |
| ELOA2 | Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII subunit A2) (Transcription elongation factor B polypeptide 3B) | 5 | UniProt NCBI |
| CEACAM6 | Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c) | 5 | UniProt NCBI |
| ELANE | Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) | 5 | UniProt NCBI |
| CFAP58 | Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) | 5 | UniProt NCBI |
| LRRC17 | Leucine-rich repeat-containing protein 17 (p37NB) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000246 | 0.010616928998 | 0.5 | PRTN3 ELANE CEACAM6 | Sinusitis |
| HP:0000245 | 0.0150022431813 | 0.5 | PRTN3 ELANE CEACAM6 | Abnormal paranasal sinus morphology |
| REAC:R-HSA-6803157 | 0.0407966660198 | 0.333333333333 | PRTN3 ELANE | Antimicrobial peptides |
| HP:0031690 | 0.0499762286031 | 0.333333333333 | CEACAM6 ELANE | Opportunistic infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRRC17 | ELANE | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LRRC17 | PRTN3 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CEACAM6 | ELOA2 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CFAP58 | ELOA2 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ELOA2 | ELANE | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ELOA2 | PRTN3 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PRTN3 | ELANE | 0.638 | 0.356 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| CEACAM6 | PRTN3 | 0.49 | bioplex3_WMM WMM_only | ||
| CEACAM6 | ELANE | 0.477 | bioplex3_WMM WMM_only | ||
| CEACAM6 | CFAP58 | 0.415 | bioplex3_WMM WMM_only | ||
| CFAP58 | ELANE | 0.274 | bioplex3_WMM WMM_only | ||
| CFAP58 | PRTN3 | 0.21 | bioplex3_WMM WMM_only |
Related Complexes